Migration of diethylhexyl phthalate from PVC bags into intravenous cyclosporine solutions

Gotardo, M. A.; Monteiro, Magali

doi:10.1016/j.jpba.2005.02.005

Cited by 16 publications

(8 citation statements)

References 25 publications

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“…1 The major problem of the PVC bags for drug infusion purpose is that di-(2-ethylhexyl) phthalate (DEHP), the main plasticizer used in manufacturing PVC bags, can leach into the infusion solutions. [2][3][4][5][6] DEHP, when injected into the human patients, may have adverse effects on their bodies including chronic toxicities on the liver and the reproductive systems. [5][6][7] To overcome these problems, several types of non-PVC bags comprised of polyolefins, such as polyethylene and polypropylene (PP), have been developed.…”

Section: Introductionmentioning

confidence: 99%

“…[2][3][4][5][6] DEHP, when injected into the human patients, may have adverse effects on their bodies including chronic toxicities on the liver and the reproductive systems. [5][6][7] To overcome these problems, several types of non-PVC bags comprised of polyolefins, such as polyethylene and polypropylene (PP), have been developed. 1,2 Because these non-PVC products do not contain DEHP, concerns over leaching can be eliminated.…”

Section: Introductionmentioning

confidence: 99%

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Compatibility of diazepam with polypropylene multilayer infusion container

et al. 2009

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Techflex ® , a polypropylene-lined, multilayer infusion bag, was studied for its compatibility with diazepam, in comparison to the conventional infusion bag, Safeflex ® , which is comprised of poly(vinyl chloride) (PVC). Diazepam was diluted in 0.9% sodium chloride isotonic solution and stored in the infusion bags for 24 h. To evaluate the sorption of diazepam into the infusion bags during storage, the concentration of the drug remaining in the bag was measured using gas chromatography-mass spectroscopy. The PVC bags exhibited a marked sorption of diazepam, with a drug loss reaching up to 90% of the initial concentration after 24 h of contact, whereas Techflex ® inhibited the drug sorption, showing approximately 10%, under the same conditions. The differences in the sorption behaviors of the bags are discussed in terms of solubility parameters and crystallinities of the polymers.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Compatibility of diazepam with polypropylene multilayer infusion container

et al. 2009

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“…The GC with flame ionization detector (GC-FID) was also used when phthalates were in polar solvents [9]. Kato et al [10] also used the high performance liquid chromatography (HPLC) to determine phthalates in human urine.…”

Section: Introductionmentioning

confidence: 99%

Separation and determination of phthalates by micellar electrokinetic chromatography

Guo

Wen

Shan

et al. 2005

Journal of Chromatography A

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“…In fact, until now, migration of plasticizers into food and their simulants has been the subject of many investigations [10][11][12][13][14][15][16][17][18] but few studies were carried out on the migration of other additives [19][20][21]. The most used method for the experimental study of migration phenomena is gas chromatography (GC) [5][6][7][8][9][10][11][12][13][14][15][16][17][18] which is costly and time-consuming.…”

Section: Introductionmentioning

confidence: 99%

“…The most used method for the experimental study of migration phenomena is gas chromatography (GC) [5][6][7][8][9][10][11][12][13][14][15][16][17][18] which is costly and time-consuming. Hence, it is desirable to identify simple, low-cost and rapid techniques to study these phenomena.…”

Section: Introductionmentioning

confidence: 99%

Kinetic Study of the Specific Migration of an Organotin Heat Stabilizer from Rigid Poly(vinyl chloride) into Food Simulants by FTIR Spectroscopy

Zeddam¹,

Belhaneche‐Bensemra

2010

International Journal of Polymeric Materials

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The aim of this paper is the determination of the specific migration of an organotin heat stabilizer (Irgastab 17 MOK) from rigid poly(vinyl chloride) (PVC) into food simulants. For that purpose, two fatty simulants were used: hexane and ethanol. The test conditions were 15 d at 4 and 40 C and 3 h at 70 C. The rate of the mass loss of the films was followed as a function of time. FTIR spectroscopy was used to investigate the migration phenomena and to estimate the diffusion coefficients and the activation energy of diffusion by using mathematical models. The influence of various parameters such as temperature, time of contact and the nature of food simulant was considered. The results show that FTIR spectroscopy is a simple, low cost and rapid method which can be used to investigate the migration phenomena.

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Migration of diethylhexyl phthalate from PVC bags into intravenous cyclosporine solutions

Cited by 16 publications

References 25 publications

Compatibility of diazepam with polypropylene multilayer infusion container

Compatibility of diazepam with polypropylene multilayer infusion container

Separation and determination of phthalates by micellar electrokinetic chromatography

Kinetic Study of the Specific Migration of an Organotin Heat Stabilizer from Rigid Poly(vinyl chloride) into Food Simulants by FTIR Spectroscopy

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