Migration of a strand of four seeds in low-dose-rate brachytherapy

Abstract

SUMMARYWe report a case of stranded-seed migration (one strand of four seeds), via the prostatic venous plexus to the internal pudendal vein, in low-dose-rate (LDR) prostate brachytherapy. A 70-year-old man with low-risk prostate adenocarcinoma underwent transperineal permanent seed implantation. A total of 93 iodine-125 seeds were implanted (91 stranded seeds and 2 loose seeds). Immediate postimplantation fluoroscopic image and day 1 postimplantation CT scan indicated all implanted seeds to be within the vicinity of the prostate as planned. Day 30 pelvic X-ray and CT scan revealed migration of a strand of four seeds to the right pelvis (adjacent to ischial spine). At 2 years postimplantation, the patient continues to have good disease control with prostate specific antigen level of 0.69 μg/L, and asymptomatic. To the best of our knowledge, this is the first report of migration of an entire strand of seeds following LDR prostate brachytherapy. BACKGROUND

Low‑activity 125I implantation into VX2 tumor rabbits and quantitative evaluation of the precise therapeutic effect

“…Therefore, overexpression of Bcl-2 is an important marker for tumor cell development, such as oral and maxillofacial squamous cell carcinoma and colorectal cancer (17,18). The VX 2 tumor cell line, a squamous cell carcinoma derived from rabbit papilloma induced by the ShPoe virus (19), is similar to human tumors, such as lung cancer, in terms of biochemical, biological and morphological characteristics; thus, it has been widely used in clinical research, such as in imaging diagnostics and interventional radiology (20,21).…”