Migration, invasion, and metastasis are mediated by P-Rex1 in neuroblastoma
Jillian C. Jacobson,
Jingbo Qiao,
Elizabeth D. Cochran
et al.
Abstract:Neuroblastoma accounts for approximately 15% of pediatric cancer-related deaths despite intensive multimodal therapy. This is due, in part, to high rates of metastatic disease at diagnosis and disease relapse. A better understanding of tumor biology of aggressive, pro-metastatic phenotypes is necessary to develop novel, more effective therapeutics against neuroblastoma. Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 (P-Rex1) has been found to stimulate migration, invasion, and metastasis in… Show more
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