Migration in the Saguenay Region: Evidence from Reconstituted Families, 1838–1911

Gauvreau, Danielle; Jetté, René; Bourque, Mario

doi:10.1080/01615440.1987.9955269

Cited by 3 publications

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“…By 1870, the growth of the population had become mostly intrinsic. But immigration still remained a strong process: 56% of all couples who could be identified from the parish records before 1911 as ever having been married were born outside the Saguenay (Gauvreau et al, 1987). Despite the intense immigration, considerable emigration occurred as well, and net migration rates after 1881 up to the present time are actually negative.…”

Section: Introductionmentioning

confidence: 99%

Genetic consequences of differential demographic behaviour in the Saguenay region, Québec

Heyer

1995

American J Phys Anthropol

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Some rare inherited disorders are found with a high frequency in the population of the Saguenay region (Québec province, Canada, population 300,000). Inbreeding coefficients are too low to be an explanation for these high frequencies. In the first decades of settlement (1842-1870), most of the immigrants came from a small region called Charlevoix (east of Québec city). As most of the genetic disorders found in the Saguenay region are also found in the Charlevoix region, it is strongly suspected that the genes were introduced by these first settlers from Charlevoix. Using the BALSAC database (which contains linked information on the entire Saguenay population) to calculate the number of contemporary descendants and the genetic contribution of each founder to these descendants, we show that: (1) Founders who entered the population before 1870 contribute to 45% of the contemporary gene pool, despite the fact that they represent only 15% of all the 20,012 immigrants with descendants in the contemporary population (individuals born between 1950 and 1971). (2) Their genetic contribution is not homogenous in the contemporary population: 5% of the population have 100% of their gene pool coming from these first founders, while 10% have a zero to 5% contribution from these earliest founders. (3) Fifty percent of the genes introduced in the population were lost. (4) If only 68 immigrants among the first founders (2.0%) were carriers of the same gene, it could reach a frequency of 5% in the contemporary population, which is the frequency of most of the inherited disorders found in the population.

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Section: Introductionmentioning

confidence: 99%

Genetic consequences of differential demographic behaviour in the Saguenay region, Québec

Heyer

1995

American J Phys Anthropol

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Genetic structure of the saguenay, 1852–1911: Evidence from migration and isonymy matrices

Gradie

Jorde

Bouchard

1988

American J Phys Anthropol

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The Saguenay is a region in northeastern Québec populated in the second half of the 19th century through migration from other parts of Québec. The present-day population of nearly 300,000 is the result of both immigration and high rates of intrinsic growth. This population has been of interest to geneticists because of the high incidence of certain hereditary diseases, notably spastic ataxia, tyrosinemia, agenesis of the corpus callosum, vitamin D-dependent rickets, and myotonic dystrophy. Parent-offspring migration and isonymy matrices were used to estimate random kinship using the Malécot model for six 10-year time periods from 1852-1911. Comparisons between two estimates of kinship--one from parent-offspring migration matrices (phi) and the other from isonymy (R)--and geographic distance were made using both product-moment and Mantel correlation. Comparisons of within- and between-subdivision kinship were made using nonparametric and Mantel correlation. Within-subdivision kinship from the phi matrix was also compared with kinship estimated from marriage dispensations for endogamous marriages. The estimates of random kinship from the parent-offspring matrices showed a good fit with geography. However, isonymy did not correlate well with geographic distance; and phi and R showed no correlation until the last two time periods, and the diagonal of phi did not correlate with the marriage dispensations. Examination of scatterplots of phi vs. R suggests that nonrandom migration during the process of settlement formation is responsible for the lack of correlation. While movement across space seems to be highly dependent on distance, nonrandom selection of migrants means that between-subdivision estimates of kinship based on migration are not congruent with those obtained by other methods. On the whole, genetic differentiation seems to have been low due to the high levels of movement between subdivisions and immigration. The weak dependence of genetic structure on geographic distances in the present population is demonstrated by mapping the geographic distribution of cases of three recessively inherited diseases.

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Migration and Hereditary Disease in the Saguenay Population of Eastern Quebéc

Gradie

Gauvreau

1987

International Migration Review

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This article examines the relationship between migration and genetic disease in the situation of the Saguenay region of Quέbec. This large population shows an elevated incidence of several genetic diseases. The process of migration, which created the population, is thought to be a major factor in determining the genetic structure of the contemporary population. Preliminary results suggest that although consanguineous marriages are not and never were frequent in the population, socially, kinship was important in determining migration and persistence, leading to a high level of genetic homogeneity today.

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Migration in the Saguenay Region: Evidence from Reconstituted Families, 1838–1911

Cited by 3 publications

References 1 publication

Genetic consequences of differential demographic behaviour in the Saguenay region, Québec

Genetic consequences of differential demographic behaviour in the Saguenay region, Québec

Genetic structure of the saguenay, 1852–1911: Evidence from migration and isonymy matrices

Migration and Hereditary Disease in the Saguenay Population of Eastern Quebéc

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