Migration and Function of a Glial Subtype in the Vertebrate Peripheral Nervous System

Gilmour, Darren; Maischein, Hans-Martin; Nüsslein‐Volhard, Christiane

doi:10.1016/s0896-6273(02)00683-9

Cited by 277 publications

(240 citation statements)

References 32 publications

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“…Labeling of the migrating AN glial cell population with anti-glutamine synthetase antibody shows that glial cells often appear in chains, as has been seen in other systems (Sepp et al, 2000;Gilmour et al, 2002;Silies et al, 2007;von Hilchen et al, 2008, Aigouy et al, 2008 (Fig. 3 A-D).…”

Section: Development Of the Glial Network In The Antennal Nervesupporting

confidence: 72%

Development of a glial network in the olfactory nerve: role of calcium and neuronal activity

2010

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In adult olfactory nerves of mammals and moths, a network of glial cells ensheathes small bundles of olfactory receptor axons. In the developing antennal nerve (AN) of the moth Manduca sexta, the axons of olfactory receptor neurons (ORNs) migrate from the olfactory sensory epithelium toward the antennal lobe. Here we explore developmental interactions between ORN axons and AN glial cells. During early stages in AN glial-cell migration, glial cells are highly dye coupled, dividing glia are readily found in the nerve and AN glial cells label strongly for glutamine synthetase. By the end of this period, dye-coupling is rare, glial proliferation has ceased, glutamine synthetase labeling is absent, and glial processes have begun to extend to enwrap bundles of axons, a process that continues throughout the remainder of metamorphic development. Whole-cell and perforated-patch recordings in vivo from AN glia at different stages of network formation revealed two potassium currents and an R-like calcium current. Chronic in vivo exposure to the R-type channel blocker SNX-482 halted or greatly reduced AN glial migration. Chronically blocking spontaneous Na-dependent activity by injection of tetrodotoxin reduced the glial calcium current implicating an activity-dependent interaction between ORNs and glial cells in the development of glial calcium currents.

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Section: Development Of the Glial Network In The Antennal Nervesupporting

confidence: 72%

Development of a glial network in the olfactory nerve: role of calcium and neuronal activity

2010

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“…NRG1 signaling is also important in directed cell migration of SCPs as shown by elegant studies in the zebrafish by Gilmour et al (2002), and subsequently by Lyons et al (2005) (reviewed in Lai, 2005). By analyzing different zebrafish mutants, these researchers showed that axons provide guidance cues, in the form of ErbB signaling, for directed migration of SCPs.…”

Section: Axonal-glial Interactions In Developing Nerves and Their Impmentioning

confidence: 99%

Development of the Schwann cell lineage: From the neural crest to the myelinated nerve

Woodhoo

Sommer

2008

Glia

203

185

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The myelinating and nonmyelinating Schwann cells in peripheral nerves are derived from the neural crest, which is a transient and multipotent embryonic structure that also generates the other main glial subtypes of the peripheral nervous system (PNS). Schwann cell development occurs through a series of transitional embryonic and postnatal phases, which are tightly regulated by a number of signals. During the early embryonic phases, neural crest cells are specified to give rise to Schwann cell precursors, which represent the first transitional stage in the Schwann cell lineage, and these then generate the immature Schwann cells. At birth, the immature Schwann cells differentiate into either the myelinating or nonmyelinating Schwann cells that populate the mature nerve trunks. In this review, we will discuss the biology of the transitional stages in embryonic and early postnatal Schwann cell development, including the phenotypic differences between them and the recently identified signaling pathways, which control their differentiation and maintenance. In addition, the role and importance of the microenvironment in which glial differentiation takes place will be discussed. V V C 2008 Wiley-Liss, Inc.

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“…Interneuromast cells deposited by primI are normally kept quiescent for several days by the glial cells that accompany the afferent axons (Grant et al, 2005;Lopez-Schier and Hudspeth, 2005). Ganglion ablation prevents the migration of glial cells along afferent axons (Gilmour et al, 2002), therefore leading to precocious proliferation of interneuromast cells and to the formation of intercalary neuromasts. We examined the extent of reinnervation after ganglion ablation at 24 hpf in seven SqET20 embryos, where the mantle cells of neuromasts and the interneuromast cells express GFP (Parinov et al, 2004).…”

Section: Neuromast Innervation By the Regenerated Ganglionmentioning

confidence: 99%

Origin and Early Development of the Posterior Lateral Line System of Zebrafish

Sarrazin¹,

Nuñez²,

Sapède³

et al. 2010

Journal of Neuroscience

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The lateral line system of teleosts has recently become a model system to study patterning and morphogenesis. However, its embryonic origins are still not well understood. In zebrafish, the posterior lateral line (PLL) system is formed in two waves, one that generates the embryonic line of seven to eight neuromasts and 20 afferent neurons and a second one that generates three additional lines during larval development. The embryonic line originates from a postotic placode that produces both a migrating sensory primordium and afferent neurons. Nothing is known about the origin and innervation of the larval lines. Here we show that a "secondary" placode can be detected at 24 h postfertilization (hpf), shortly after the primary placode has given rise to the embryonic primordium and ganglion. The secondary placode generates two additional sensory primordia, primD and primII, as well as afferent neurons. The primary and secondary placodes require retinoic acid signaling at the same stage of late gastrulation, suggesting that they share a common origin. Neither primary nor secondary neurons show intrinsic specificity for neuromasts derived from their own placode, but the sequence of neuromast deposition ensures that neuromasts are primarily innervated by neurons derived from the cognate placode. The delayed formation of secondary afferent neurons accounts for the capability of the fish to form a new PLL ganglion after ablation of the embryonic ganglion at 24 hpf.

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Migration and Function of a Glial Subtype in the Vertebrate Peripheral Nervous System

Cited by 277 publications

References 32 publications

Development of a glial network in the olfactory nerve: role of calcium and neuronal activity

Development of a glial network in the olfactory nerve: role of calcium and neuronal activity

Development of the Schwann cell lineage: From the neural crest to the myelinated nerve

Origin and Early Development of the Posterior Lateral Line System of Zebrafish

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