Migration and differentiation of adult rat subventricular zone progenitor cells transplanted into the adult rat striatum

Zhang, R.L; Zhang, L; Zhang, Z.G; Morris, Daniel C.; Jiang, Quan; Wang, L; Chopp, Michael

doi:10.1016/s0306-4522(02)00696-6

Cited by 93 publications

(68 citation statements)

References 27 publications

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“…Chemokines may attract neural progenitor cells to these areas where they may develop into progeny that are appropriate for repair purposes. Thus, the migration and development of neural progenitors into neurons in models of stroke Zhang et al, 2003Zhang et al, , 2004a and into oligodendrocytes in models of demyelination (Ben-Hur et al, 2003;Pluchino et al, 2003Pluchino et al, , 2005 have been demonstrated in several studies. On the other hand, many progenitor cells that migrate in the diseased brain fail to differentiate into the appropriate progeny owing to the production of cytokines such as IL-6 at neuroinflammatory sites that direct progenitors to become astrocytes, or other factors that lead to progenitor cell death (Ekdahl et al, 2003;Monje et al, 2003).…”

Section: Discussionmentioning

confidence: 99%

“…Such directed migration of progenitors has been a commonly observed phenomenon. It has been shown that endogenous or transplanted progenitors will migrate toward focal or diffuse areas of brain damage or demyelination, although the mechanisms responsible for this directed migration are unknown (Fricker et al, 1999;Aboody et al, 2000;Arvidsson et al, 2002;Ben-Hur et al, 2003;Parent, 2003;Pluchino et al, 2003Pluchino et al, , 2005Zhang et al, 2003Zhang et al, , 2004aGlass et al, 2005). As chemokine synthesis is greatly upregulated in these areas, it seems reasonable to speculate that chemokines regulate the observed progenitor cell migration.…”

Section: Discussionmentioning

confidence: 99%

“…However, experiments have demonstrated that in response to trauma, injury, infection, or neurodegneration, progenitor cells in these neurogenic areas, or populations of latent neural progenitors throughout the neuraxis, can migrate toward areas of brain injury, presumably in an attempt at self repair (Nakatomi et al, 2002;Picard-Riera et al, 2002;Taupin and Gage, 2002;Kokaia and Lindvall, 2003;Jin et al, 2004; Zhang et al, 2004a,b;Glass et al, 2005). In a variation of this paradigm, neural progenitor cells that have been propagated in culture can be introduced into the brain and can also be observed to migrate toward damaged areas (Ben-Hur et al, 2003;Pluchino et al, 2003Pluchino et al, , 2005Zhang et al, 2003; Imatola et al, 2004;Kelly et al, 2004;Lindvall et al, 2004). An important question is: What guides this directed migration of endogenous or exogenous progenitor cells?…”

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confidence: 99%

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Chemokine receptor expression by neural progenitor cells in neurogenic regions of mouse brain

Tran

Banisadr

Ren

et al. 2006

J of Comparative Neurology

219

228

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We previously demonstrated that chemokine receptors are expressed by neural progenitors grown as cultured neurospheres. To examine the significance of these findings for neural progenitor function in vivo, we investigated whether chemokine receptors were expressed by cells having the characteristics of neural progenitors in neurogenic regions of the postnatal brain. Using in situ hybridization we demonstrated the expression of CCR1, CCR2, CCR5, CXCR3, and CXCR4 chemokine receptors by cells in the dentate gyrus (DG), subventricular zone of the lateral ventricle, and olfactory bulb. The pattern of expression for all of these receptors was similar, including regions where neural progenitors normally reside. In addition, we attempted to colocalize chemokine receptors with markers for neural progenitors. In order to do this we used nestin-EGFP and TLXLacZ transgenic mice, as well as labeling for Ki67, a marker for dividing cells. In all three areas of the brain we demonstrated colocalization of chemokine receptors with these three markers in populations of cells. Expression of chemokine receptors by neural progenitors was further confirmed using CXCR4-EGFP BAC transgenic mice. Expression of CXCR4 in the DG included cells that expressed nestin and GFAP as well as cells that appeared to be immature granule neurons expressing PSA-NCAM, calretinin, and Prox-1. CXCR4-expressing cells in the DG were found in close proximity to immature granule neurons that expressed the chemokine SDF-1/CXCL12. Cells expressing CXCR4 frequently coexpressed CCR2 receptors. These data support the hypothesis that chemokine receptors are important in regulating the migration of progenitor cells in postnatal brain. Indexing terms stem cells; development; chemotaxis; brain repairDuring embryogenesis, neural stem/progenitor cells must migrate long distances from the germinal epithelia where they are born to their final destinations (Hatten, 1999;Alvarez-Buylla et al., 2001). During migration, stem cells may continue to divide and also become restricted in terms of their ultimate phenotypes. Thus, the timing of neuro-and gliogenesis in the developing embryo is precisely controlled (Rallu et al., 2002). The factors that determine the migration, proliferation, and differentiation of embryonic stem cells have been widely investigated and numerous factors have been shown to influence these processes (Lindvall et al., 2004). One group of molecules that has recently been shown to control progenitor cell migration in the nervous system are the chemokines (CHEMO-tactic cytoKINES) (Tran and © NIH-PA Author ManuscriptNIH-PA Author Manuscript NIH-PA Author Manuscript Miller, 2003). The chemokines are a family of small secreted proteins that are known to be important regulators of leukocyte trafficking under both normal conditions and during inflammatory responses (Moser et al., 2004). Furthermore, it is now known that chemokine signaling has an important role to play in the developing embryo. Deletion of the genes for the CXCR4 chemokine receptor or f...

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

See 1 more Smart Citation

Chemokine receptor expression by neural progenitor cells in neurogenic regions of mouse brain

Tran

Banisadr

Ren

et al. 2006

J of Comparative Neurology

219

228

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“…Stroke promotes SVZ cell migration toward the ischemic boundary region (Arvidsson et al, 2002;Parent et al, 2002;Jin et al, 2003;Zhang et al, 2003Zhang et al, , 2004a. However, migratory characteristics of SVZ cells after stroke have not been established.…”

Section: Discussionmentioning

confidence: 99%

Neuroblast Division during Migration toward the Ischemic Striatum: A Study of Dynamic Migratory and Proliferative Characteristics of Neuroblasts from the Subventricular Zone

Zhang¹,

LeTourneau²,

Gregg³

et al. 2007

J. Neurosci.

116

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“…Only very small movement of the transplanted cells was detected between 1 and 6 weeks (compare Figures 2E with 2F and 2G for cell localization). Expanded dark areas (such as a and b in Figures 2F and 2G) appeared at later time points (between 2 and 6 weeks) for all cell treated animals and this indicated that the grafted cells were alive (Bulte et al, 1999;Zhang et al, 2003a). Double immunohistochemistry staining revealed that Prussian blue positive cells within the ischemic boundary zone were not co-localized to EBA positive vessels (Figures 3A-3C) and GFAP positive cells (Figures 3D-3F).…”

Section: The Destination Of Grafted Subventricular Zone Cells and Phementioning

confidence: 93%

Ischemic Cerebral Tissue Response to Subventricular Zone Cell Transplantation Measured by Iterative Self-Organizing Data Analysis Technique Algorithm

Li¹,

Jiang²,

Zhang³

et al. 2006

J Cereb Blood Flow Metab

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To investigate the changes of the ischemic lesion in rat brain after subventricular zone (SVZ) cell transplantation and the influence of the grafted cells on the appearance of angiogenesis, SVZ cells, superparamagnetically labeled, were intracisternally transplanted into the rat brain 48 h after onset of embolic stroke. A complete set of magnetic resonance (MR) images was acquired for all animals with (n = 8) and without (n = 3) cell grafting at approximately 24 h, 72 h, and weekly for 6 weeks after stroke. Transplanted cells were tracked by high-resolution three-dimensional gradient-echo images and the interaction between the cells and ischemic lesion was detected by ISODATA (Iterative SelfOrganizing Data Analysis Technique Algorithm) calculated from T 1 , T 2 and T 1sat maps. Tissue status from ISODATA was characterized by a specific signature, which represents the deviation from normal tissue in the feature space. Transplanted SVZ cells selectively migrated towards the ischemic side of the rat brain and approached the lesion boundary within 1-week after grafting. Cell treated rats exhibited a significant reduction of average lesion size compared with control rats (P < 0.05). A significant reduction of tissue signature (P < 0.001) induced by cell transplantation was localized to the position of grafted cells, and these sites exhibited stably restored cerebral blood flow (CBF) (approximately 85% of normal CBF). Angiogenesis was present in sites either immediately adjacent to or surrounded by the grafted cells. Our data indicate that map-ISODATA accurately and dynamically characterizes the ischemic lesion and its response to cell therapy.

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Migration and differentiation of adult rat subventricular zone progenitor cells transplanted into the adult rat striatum

Cited by 93 publications

References 27 publications

Chemokine receptor expression by neural progenitor cells in neurogenic regions of mouse brain

Chemokine receptor expression by neural progenitor cells in neurogenic regions of mouse brain

Neuroblast Division during Migration toward the Ischemic Striatum: A Study of Dynamic Migratory and Proliferative Characteristics of Neuroblasts from the Subventricular Zone

Ischemic Cerebral Tissue Response to Subventricular Zone Cell Transplantation Measured by Iterative Self-Organizing Data Analysis Technique Algorithm

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