Migraine with aura: less control over pain and fragrances?

Mignot, Coralie; Faria, Vanda; Hummel, Thomas; Frost, Marie; Michel, Christoph M.; Goßrau, Gudrun; Haehner, Antje

doi:10.1186/s10194-023-01592-3

Cited by 6 publications

(4 citation statements)

References 86 publications

(107 reference statements)

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“…Nicotine may have anti-nociceptive effects [52] and tobacco smoking has been linked to coping mechanisms related to migraine and chronic head pain [53]. Additionally, the interplay between nociception and olfaction has been proposed at both molecular and functional levels [54,55]. In this context, our results reinforce the hypothesis of shared genetic mechanisms predisposing individuals with certain chemosensory abilities to tobacco smoking behaviors.…”

Section: Discussionsupporting

confidence: 79%

Brain-wide pleiotropy investigation of alcohol drinking and tobacco smoking behaviors

Deiana,

He,

Cabrera-Mendoza

et al. 2024

Preprint

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To investigate the pleiotropic mechanisms linking brain structure and function to alcohol drinking and tobacco smoking, we integrated genome-wide data generated by the GWAS and Sequencing Consortium of Alcohol and Nicotine use (GSCAN; up to 805,431 participants) with information related to 3,935 brain imaging-derived phenotypes (IDPs) available from UK Biobank (N=33,224). We observed global genetic correlation of smoking behaviors with white matter hyperintensities, the morphology of the superior longitudinal fasciculus, and the mean thickness of pole-occipital. With respect to the latter brain IDP, we identified a local genetic correlation with age at which the individual began smoking regularly (hg38 chr2:35,895,678-36,640,246: rho=1, p=1.01e-5). This region has been previously associated with smoking initiation, educational attainment, chronotype, and cortical thickness. Our genetically informed causal inference analysis using both latent causal variable approach and Mendelian randomization linked the activity of prefrontal and premotor cortex and that of superior and inferior precentral sulci, and cingulate sulci to the number of alcoholic drinks per week (genetic causality proportion, gcp=0.38, p=8.9e-4, rho=-0.18+-0.07; inverse variance weighting, IVW beta=-0.04, 95%CI=-0.07, -0.01). This relationship could be related to the role of these brain regions in the modulation of reward-seeking motivation and the processing of social cues. Overall, our brain-wide investigation highlighted that different pleiotropic mechanisms likely contribute to the relationship of brain structure and function with alcohol drinking and tobacco smoking, suggesting decision-making activities and chemosensory processing as modulators of propensity towards alcohol and tobacco consumption.

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Section: Discussionsupporting

confidence: 79%

Brain-wide pleiotropy investigation of alcohol drinking and tobacco smoking behaviors

Deiana,

He,

Cabrera-Mendoza

et al. 2024

Preprint

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“…The sample size of the study did not allow us to run sub-group analyses focusing on chemosensory functions in migraineurs with and without aura, whereas in the adult populations, these groups differ in chemosensory processing [ 61 ]. This constitutes a limitation of the presented research.…”

Section: Discussionmentioning

confidence: 99%

Children and adolescents with primary headaches exhibit altered sensory profiles – a multi-modal investigation

Pieniak,

Höfer,

Knipping

et al. 2024

J Headache Pain

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Background Pediatric headache is an increasing medical problem that has adverse effects on children’s quality of life, academic performance, and social functioning. Children with primary headaches exhibit enhanced sensory sensitivity compared to their healthy peers. However, comprehensive investigations including multimodal sensory sensitivity assessment are lacking. This study aimed to compare sensory sensitivity of children with primary headaches with their healthy peers across multiple sensory domains. Methods The study included 172 participants aged 6 to 17 years (M = 13.09, SD = 3.02 years; 120 girls). Of these 80 participants were patients with migraine, 23 were patients with tension-type headache, and 69 were healthy controls. The following sensory measures were obtained: Mechanical Detection Threshold (MDT), Mechanical Pain Threshold (MPT), Mechanical Pain Sensitivity (MPS), detection and pain threshold for Transcutaneous Electrical Nerve Stimulation (TENS), olfactory and intranasal trigeminal detection threshold, and odor identification ability. Sensory sensitivity was compared between groups with a series of Kruskal-Wallis tests. Binomial regression models were used to compare the relative utility of sensory sensitivity measures in classifying participants into patients and healthy controls, as well as into patients with migraine and tension-type headache. Results Patients with migraine had lower MPT measured at the forearm than patients with tension-type headaches and healthy controls. MPS was higher in patients with migraine than in healthy controls. All patients with headaches had lower detection threshold of TENS and higher olfactory sensitivity. Healthy controls showed increased intranasal trigeminal sensitivity. Scores in MPS, TENS, and olfactory and trigeminal thresholds were significantly predicting presence of primary headaches. Additionally, scores in MPT, olfactory and trigeminal threshold were positive predictors of type of headache. Conclusions Children with primary headaches exhibit different sensory profiles than healthy controls. The obtained results suggest presence of increased overall, multimodal sensitivity in children with primary headaches, what may negatively impact daily functioning and contribute to further pain chronification. Trial registration The study was registered in the German Registry of Clinical Trials (DRKS) DRKS00021062.

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“…To focus the data analysis, only recordings from midline electrodes Fz, Cz, and Pz were included in this analysis. A time–frequency analysis (TFA) based on the continuous Morlet Wavelet Transform (CWT) of individual EEG epochs was used to characterize the amplitude of oscillatory activity as a function of time and frequency, according to previous studies 52 , 53 . Based on previous findings in olfactory ERPs 25 , frequencies ranging from 0.5 to 12 Hz were taken into consideration.…”

Section: Methodsmentioning

confidence: 99%

Time–frequency analysis of gustatory event related potentials (gERP) in taste disorders

Mastinu,

Grzeschuchna,

Mignot

et al. 2024

Sci Rep

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In taste disorders, the key to a correct diagnosis and an adequate treatment is an objective assessment. Compared to psychophysical tests, EEG-derived gustatory event-related potentials (gERP) could be used as a less biased measure. However, the responses identified using conventional time-domain averaging show a low signal-to-noise ratio. This study included 44 patients with dysgeusia and 59 healthy participants, who underwent a comprehensive clinical examination of gustatory function. gERPs were recorded in response to stimulation with two concentrations of salty solutions, which were applied with a high precision gustometer. Group differences were examined using gERP analyzed in the canonical time domain and with Time–Frequency Analyses (TFA). Dysgeusic patients showed significantly lower scores for gustatory chemical and electrical stimuli. gERPs failed to show significant differences in amplitudes or latencies between groups. However, TFA showed that gustatory activations were characterized by a stronger power in controls than in patients in the low frequencies (0.1–4 Hz), and a higher desynchronization in the alpha-band (8–12 Hz). Hence, gERPs reflect the altered taste sensation in patients with dysgeusia. TFA appears to enhance the signal-to-noise ratio commonly present when using conventional time-domain averaging, and might be of assistance for the diagnosis of dysgeusia.

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Migraine with aura: less control over pain and fragrances?

Cited by 6 publications

References 86 publications

Brain-wide pleiotropy investigation of alcohol drinking and tobacco smoking behaviors

Brain-wide pleiotropy investigation of alcohol drinking and tobacco smoking behaviors

Children and adolescents with primary headaches exhibit altered sensory profiles – a multi-modal investigation

Time–frequency analysis of gustatory event related potentials (gERP) in taste disorders

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