Migraine, Tension-Type Headache, and Attention-Deficit/Hyperactivity Disorder in Childhood: A Population-Based Study

Arruda, Marco A.; Guidetti, Vincenzo; Galli, Federica; Albuquerque, Regina; Bigal, Marcelo E.

doi:10.3810/pgm.2010.09.2197

Cited by 50 publications

(63 citation statements)

References 44 publications

(35 reference statements)

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“…Primary headache, such as migraine and tension-type headache, affects Brazilian children with a prevalence rate of 12.3% and 4.2%, respectively (2). Although the origin or worsening of headache in children and adolescents may also be related to temporomandibular joint disorder (TMJD), few studies have addressed this association.…”

Section: Introductionmentioning

confidence: 99%

Association between headache and temporomandibular joint disorders in children and adolescents

et al. 2013

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Section: Introductionmentioning

confidence: 99%

Association between headache and temporomandibular joint disorders in children and adolescents

et al. 2013

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“…Strine et al [23] evidenced an odds ratio of 2.6 to have inattention and hyperactivity in children who referred headache, and Genizi et al showed that learning disabilities and ADHD are more common in children and adolescents who are referred for neurological assessment for primary headaches than those described in the general pediatric population [1], while Arruda et al demonstrated that migraine and TTH are not comorbid to ADHD overall but are comorbid to hyperactive-impulsive behavior [20].…”

Section: Introductionmentioning

confidence: 97%

“…Concentration difficulties and hyperactivity are psychological predictors of headaches [18], and at the same time, frequent headaches may increase distractibility and are associated with impaired attention span [19] and hyperactivityimpulsivity disease [20,21].…”

Section: Introductionmentioning

confidence: 99%

Headache and ADHD in Pediatric Age: Possible Physiopathological Links

Paolino

Ferretti

Villa

et al. 2015

Curr Pain Headache Rep

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Primary headache and attention-deficit/hyperactivity disorder (ADHD) are common disorders in children and adolescences, frequently associated to severe cognitive, emotional, and behavioral impairments. They both are a disabling condition with consequences on family and child's quality of life. Literature data on their association are contrasting. Dopaminergic system dysfunction, brain iron deficiency, and sleep disturbance should be considered to better understand headache and ADHD overlap. In this review, we analyze the complex association between these two diseases and the potential impact on child neurodevelopment.

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“…Moreover, from the last 2 decades, much attention has been given to the relevance of psychiatric comorbidities, and neurological and psychological problems 39–46. The pathophysiology of migraine implicates vascular and neurological mechanisms.…”

Section: Introductionmentioning

confidence: 99%

Pharmacoinformatics elucidation of potential drug targets against migraine to target ion channel protein KCNK18

Sehgal¹,

Hassan²,

Rashid³

2014

DDDT

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Migraine, a complex debilitating neurological disorder is strongly associated with potassium channel subfamily K member 18 (KCNK18). Research has emphasized that high levels of KCNK18 may be responsible for improper functioning of neurotransmitters, resulting in neurological disorders like migraine. In the present study, a hybrid approach of molecular docking and virtual screening were followed by pharmacophore identification and structure modeling. Screening was performed using a two-dimensional similarity search against recommended migraine drugs, keeping in view the physicochemical properties of drugs. LigandScout tool was used for exploring pharmacophore properties and designing novel molecules. Here, we report the screening of four novel compounds that have showed maximum binding affinity against KCNK18, obtained through the ZINC database, and Drug and Drug-Like libraries. Docking studies revealed that Asp-46, Ile-324, Ile-44, Gly-118, Leu-338, Val-113, and Phe-41 are critical residues for receptor–ligand interaction. A virtual screening approach coupled with docking energies and druglikeness rules illustrated that ergotamine and PB-414901692 are potential inhibitor compounds for targeting KCNK18. We propose that selected compounds may be more potent than the previously listed drug analogs based on the binding energy values. Further analysis of these inhibitors through site-directed mutagenesis could be helpful for exploring the details of ligand-binding pockets. Overall, the findings of this study may be helpful for designing novel therapeutic targets to cure migraine.

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Migraine, Tension-Type Headache, and Attention-Deficit/Hyperactivity Disorder in Childhood: A Population-Based Study

Abstract: Migraine and TTH are not comorbid to ADHD overall, but are comorbid to hyperactive-impulsive behavior. Providers and educators should be aware of the association.

Cited by 50 publications

References 44 publications

Association between headache and temporomandibular joint disorders in children and adolescents

Association between headache and temporomandibular joint disorders in children and adolescents

Headache and ADHD in Pediatric Age: Possible Physiopathological Links

Pharmacoinformatics elucidation of potential drug targets against migraine to target ion channel protein KCNK18

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