Migraine preventive drugs differentially affect cortical spreading depression in rat

Bogdanov, Volodymyr B.; Multon, Sylvie; Chauvel, Virginie; Bogdanova, Olena V.; Prodanov, Dimiter; Makarchuk, Mykola Yukhymovych; Schoenen, Jean

doi:10.1016/j.nbd.2010.10.014

Cited by 96 publications

(84 citation statements)

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“…Seventeen adult male Sprague-Dawley rats were randomly chosen among those used in a previously published study on the effect of preventive anti-migraine drugs on CSD [6]. The animals weighed between 300 g and 480 g on the day of recordings.…”

Section: Experimental Animalsmentioning

confidence: 99%

“…The animals weighed between 300 g and 480 g on the day of recordings. All animals were separated randomly onto three experimental groups during the therapeutic study [6]. Five rats were sham-operated and received no treatment.…”

Section: Experimental Animalsmentioning

confidence: 99%

“…The detailed stimulation and recording procedures were described previously [6]. Briefly, after surgery that lasted 30-40 min, in all animals except in the sham-operated group, we induced CSD with a cotton ball soaked with 1 M KCl placed over the occipital cortex (AP-7, R + 2).…”

Section: Csd Provocation and Recordingsmentioning

confidence: 99%

“…The results on CSD numbers and propagation were reported and discussed previously [6] and will not be described in detail here. Briefly, in lamotrigine treated group frequencies of occipito-parietal and frontal CSDs (4.4 ± 3.1 and 1.6 ± 0.8, respectively) were significantly reduced comparatively to saline treated animals (6.7 ± 0.9 and 3.4 ± 0.8, respectively).…”

Section: Csd Numbersmentioning

confidence: 99%

“…Fos expression, a validated marker of neuronal activation, was used to estimate activity of PAG neurons after artificial provocation of CSDs over the occipital cortex of anesthetized rats. Since we previously shown that lamotrigine (LTG) is a potent inhibitor of KCl-induced CSD in rat cerebral cortex [6], we included LTG-treated animals in that study to verify if pharmacological suppression of CSDs abolishes the effect of CSDs on PAG.…”

Section: Introductionmentioning

confidence: 99%

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Cortical spreading depression decreases Fos expression in rat periaqueductal gray matter

Bogdanov

Bogdanova

Lombard

et al. 2015

Neuroscience Letters

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h i g h l i g h t s• Cortical spreading depression (CSD) likely underlies migraine aura.• Periaqueductal gray matter (PAG) controls pain and autonomic functions.• CSD provocation decreased neuronal Fos in PAG and Edinger-Westphal nucleus of rats.• The numbers of CSDs correlated negatively with Fos-immunoreactive counts. a r t i c l e i n f o a b s t r a c tThe migraine headache involves activation and central sensitization of the trigeminovascular pain pathway. The migraine aura is likely due to cortical spreading depression (CSD), a propagating wave of brief neuronal depolarization followed by prolonged inhibition. The precise link between CSD and headache remains controversial. Our objectives were to study the effect of CSD on neuronal activation in the periaqueductal grey matter (PAG), an area known to control pain and autonomic functions, and to be involved in migraine pathogenesis. Fos-immunoreactive nuclei were counted in rostral PAG and Edinger-Westphal nuclei (PAG-EWn bregma −6.5 mm), and caudal PAG (bregma −8 mm) of 17 adult male Sprague-Dawley rats after KCl-induced CSD under chloral hydrate anesthesia. Being part of a pharmacological study, six animals had received, for the preceding 4 weeks daily, intraperitoneal injections of lamotrigine (15 mg/kg), six others had been treated with saline, while five sham-operated animals served as controls. We found that the number of Fos-immunoreactive nuclei in the PAG decreased after CSD provocation. There was no difference between lamotrigine-and saline-treated animals. The number of CSDs correlated negatively with Fos-immunoreactive counts. CSD-linked inhibition of neuronal activity in the PAG might play a role in central sensitization during migraine attacks and contribute to a better understanding of the link between the aura and the headache.

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Section: Experimental Animalsmentioning

confidence: 99%

Section: Experimental Animalsmentioning

confidence: 99%

Section: Csd Provocation and Recordingsmentioning

confidence: 99%

Section: Csd Numbersmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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