Migraine is associated with better cognition in the middle‐aged and elderly: the Rotterdam Study

Wen, Kexin; Nguyen, Nga; Hofman, Albert; Ikram, M. Arfan; Franco, Oscar H.

doi:10.1111/ene.13066

Cited by 32 publications

(42 citation statements)

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“…Previous studies found that patients with migraine showed normal range of performance on both the MMSE [39] and MoCA [40]. Similarly, none were excluded due to abnormal performance on screening tests among migraineurs in this study.…”

Section: Discussionmentioning

confidence: 94%

Subjective cognitive decline in patients with migraine and its relationship with depression, anxiety, and sleep quality

2017

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BackgroundCognitive decline is a major concern in patients with migraine. Depression, anxiety, and/or poor sleep quality are well-known comorbidities of migraine, but available evidence on the subjective cognitive decline (SCD) is limited. This study aimed to investigate the presence and frequency of SCD and its relationship with anxiety, depression and sleep quality in patients with migraine.MethodsWe enrolled patients with migraine who scored within the normal range of the Korean-Mini Mental State Examination and the Korean-Montreal Cognitive Assessment. Using the Subjective Cognitive Decline Questionnaire (SCD-Q), participants with ≥7 were assigned to the SCD group. The Headache Impact Test-6, Generalized Anxiety Disorder-7, Patient Health Questionnaire-9, and Pittsburgh Sleep Quality Index were used and analyzed between the two groups.ResultsA total of 188 patients with migraine, aged 38.1 ± 9.9 years, were enrolled. The mean SCD-Q score was 6.5 ± 5.5, and 44.7% of participants were identified as SCD. Migraineurs with SCD reported higher headache pain intensity and headache impact, as well as greater prevalence of anxiety, depression, reduced quality of sleep, and shorter sleep duration during weekdays compared to migraineurs without SCD. There were no significant differences in terms of age, sex, migraine type (chronic/episodic), medication, or sleep duration during weekends between the two groups. Upon multivariate logistic analysis adjusted for age, sex, headache characteristics, and psychological variables, depression was associated with increased risk of SCD (Odds ratio 1.31, 95% confidence interval 1.16–1.49) and sleep duration during weekdays was associated with decreased risk of SCD (Odds ratio 0.66, 95% confidence interval 0.44–0.97).ConclusionsA non-negligible number of patients with migraine complained of SCD. Depression and short sleep duration during weekdays were related to SCD among adult migraineurs.

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Section: Discussionmentioning

confidence: 94%

Subjective cognitive decline in patients with migraine and its relationship with depression, anxiety, and sleep quality

2017

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“…Some studies suggest that migraineurs have subtle interictal cognitive abnormalities aligning with attentional deficits [9–11]. Some studies have reported improved performance [12]. Some longitudinal studies have suggested fewer dysfunctions in the Mini Mental State Examination (MMSE) and executive functions in migraineurs.…”

Section: Introductionmentioning

confidence: 99%

Duration and frequency of migraines affect cognitive function: evidence from neuropsychological tests and event-related potentials

et al. 2017

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BackgroundThe aim of this study was to evaluate the changes in the cognitive performance of migraine patients using a comprehensive series of cognitive/behavioral and electrophysiological tests.MethodA randomized, cross-sectional, within subject approach was used to compare neuropsychological and electrophysiological evaluations from migrane-affected and healthy subjects.ResultsThirty-four patients with migraine (6 males, 28 females, average 36 years old) were included. Migraineurs performed worse in the majority of the Montreal Cognitive Assessment (MoCA) (p = 0.007) compared to the healthy subjects, significantly in language (p = 0.005), memory (p = 0.006), executive functions (p = 0.042), calculation (p = 0.018) and orientation (p = 0.012). Migraineurs had a lower score on the memory trial of the Rey–Osterrieth complex figure test (ROCF) (p = 0.012). The P3 latency in Fz, Cz, Pz was prolonged in migraineurs compared with the normal control group (P < 0.001). In addition, we analyzed significant correlations between MoCA score and the duration of migraine. We also observed that a decrease in the MoCA-executive functions and calculation score and in the ROCF-recall score were both correlated to the frequency of migraine. Migraineurs were more anxious than healthy subjects (p = 0.001), which is independent of cognitive testing. Differences were unrelated to age, gender and literacy.ConclusionsCognitive performance decreases during migraine, and cognitive dysfunction can be related to the duration and frequency of a migraine attack.

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“…Neuromuscular disorders , trauma , neuro‐inflammation , headache and more general neurological topics complete the 2016 spectrum of the Journal's purview.…”

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confidence: 99%

“…Neuromuscular disorders , trauma [214,215], neuro-inflammation [216][217][218][219][220][221][222][223], headache [224][225][226][227][228][229][230][231] and more general neurological topics [232][233][234][235][236][237][238][239][240][241][242][243][244][245][246][247][248]…”

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confidence: 99%

Advances and insights into neurological practice 2016−17

Schapira¹

2017

Euro J of Neurology

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Migraine is associated with better cognition in the middle‐aged and elderly: the Rotterdam Study

Abstract: Migraineurs, particularly migraineurs with aura, tend to score higher in cognition tests than non-migraineurs. More studies are needed to corroborate these findings.

Cited by 32 publications

References 48 publications

Subjective cognitive decline in patients with migraine and its relationship with depression, anxiety, and sleep quality

Subjective cognitive decline in patients with migraine and its relationship with depression, anxiety, and sleep quality

Duration and frequency of migraines affect cognitive function: evidence from neuropsychological tests and event-related potentials

Advances and insights into neurological practice 2016−17

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