Migraine is a Risk Factor for Hypertensive Disorders in Pregnancy: A Prospective Cohort Study

Facchinetti, Fabio; Allais, Gianni; Nappi, Rossella E.; D'Amico, Roberto; Marozio, Luca; Bertozzi, Lorena; Ornati, Alessandra; Benedetto, Chiara

doi:10.1111/j.1468-2982.2008.01704.x

Cited by 103 publications

(110 citation statements)

References 38 publications

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“…287 Interestingly, there is an emerging literature on the association between migraines and preeclampsia. [288][289][290] The most recent analysis of the United Kingdom Obstetric Surveillance System found 30 cases of antenatal stroke, for an estimated incidence of 1.5 cases per 100 000 women who delivered babies (95% CI, 1.0-2.1). Factors associated with increased risk of antenatal stroke were history of migraine (adjusted OR, 8.5; 95% CI, 1.5-62.1), gestational diabetes (adjusted OR, 26.8; 95% CI, 3.2-∞), and preeclampsia or eclampsia (adjusted OR, 7.7; 95% CI, 1.3-55.7).…”

Section: Strokementioning

confidence: 99%

Guidelines for the Prevention of Stroke in Women

Bushnell¹,

McCullough²,

Awad³

et al. 2014

Stroke

774

414

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1545Purpose-The aim of this statement is to summarize data on stroke risk factors that are unique to and more common in women than men and to expand on the data provided in prior stroke guidelines and cardiovascular prevention guidelines for women. This guideline focuses on the risk factors unique to women, such as reproductive factors, and those that are more common in women, including migraine with aura, obesity, metabolic syndrome, and atrial fibrillation. Results-We provide current evidence, research gaps, and recommendations on risk of stroke related to preeclampsia, oral contraceptives, menopause, and hormone replacement, as well as those risk factors more common in women, such as obesity/metabolic syndrome, atrial fibrillation, and migraine with aura. Conclusions-To more accurately reflect the risk of stroke in women across the lifespan, as well as the clear gaps in current risk scores, we believe a female-specific stroke risk score is warranted. (Stroke. 2014;45:1545-1588.)

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Section: Strokementioning

confidence: 99%

Guidelines for the Prevention of Stroke in Women

Bushnell¹,

McCullough²,

Awad³

et al. 2014

Stroke

774

414

View full text Add to dashboard Cite

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“…However, some of these cases may have been caused by secondary headaches, in particular those linked to hypertensive disorders [5,8]. In fact, our data did not allow us to investigate this aspect.…”

Section: Discussionmentioning

confidence: 72%

Migraine and pregnancy: an internet survey

et al. 2013

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Data in the literature show that migraine tends to improve during pregnancy in most migrainous women. The aim of this Internet survey was to obtain the most likely cross section of the situation in the general population with respect to the presence and course of migraine in pregnancy. All women who participated were asked to answer questions pertaining to their history of pregnancy and headache. One thousand and eighteen women participated in the survey; only 775 met the eligibility criteria for inclusion. One hundred and ninety-five women (25.2 %) reported having had a headache only before pregnancy, 425 (54.8 %) before and during pregnancy, and 155 (20.0 %) only during pregnancy. Women suffering from headache before and/or during pregnancy were much more likely to have headaches with more migrainous features at the ID Migraine Screener test when compared to women whose headache began during pregnancy. ''Definite migraines'' were 277/620 (44.7 %) and 26/155 (16.8 %), respectively, in the two groups (p \ 0.0001). Among the 620 females that suffered from headache before pregnancy, 375 (60.5 %) improved, 195 (31.5 %) showed complete resolution of the disorder, and 180 (29.0 %) had a reduction in headache frequency. Moreover, the multinomial logistic model (with headache pattern as dependent variable) proved fetal presentation as significant (p = 0.0042). Women with ''new headache'' (No/Yes pattern) had an OR (95 % CI) of 1.9 (1.2-3.0) of breech presentation at delivery versus those with a stable pattern of headache (Yes/Yes). Finally, women with not recent pregnancy stated they suffered from headache less than the women with recent pregnancy.

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“…In a prospective cohort study from three clinical units, designed to examine the association of migraine with hypertensive disorders of pregnancy, Faccinetti et al 9 reported as secondary outcomes that birth before 37 weeks and birth weight below 2500 g were non-significantly more frequent in the infants born to 270 women with migraine as compared with 432 women without migraine. The ORs (1.64 (0.85 to 3.16) and 1.97 (0.98, 3.98)) were further lowered by adjustment for age, family history of hypertension and smoking.…”

Section: Migraine and Preterm Birthmentioning

confidence: 99%

“…6 There is a striking increase in frequency of pregnancy-associated stroke in women with a history of migraine, although the absolute level of that risk is low. 7 Migraine is associated with pre-eclampsia, [8][9][10][11] itself a marker of risk for later ischemic stroke 12 Other disorders influenced by migraine history include endometriosis and metrorrhagia. 13 Despite these observations linking endocrine and reproductive function as well as vascular disorders with migraine, and the high prevalence of migraine in women of reproductive age, there has been relatively little attention given to whether maternal migraine or its treatment influence pregnancy outcomes.…”

Section: Introductionmentioning

confidence: 99%

Migraine and preterm birth

Blair

Nelson

2010

J Perinatol

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Objective: To investigate whether maternal migraine was associated with preterm birth.Study Design: Case-control sample within a population-based study of risk factors for cerebral palsy (CP). Infants without CP were matched for gestational age with those with CP. Maternal migraine was self-identified at first prenatal visit, most in the first trimester.Result: Infants without CP born to women with migraine had a higher rate of preterm birth (odds ratio (OR) ¼ 3.5, 95% confidence interval (CI) 1.5, 8.5), as did infants who died in the perinatal period (OR ¼ 7.3, 95% CI 0.98, 54), the difference marginal for nominal statistical significance. In all outcome groups, infants of women with migraine had a higher observed rate of suboptimal intrauterine growth. In term infants, the rate of maternal migraine was higher in those with CP than in controls (OR ¼ 2.18, 95% CI 0.92, 5.25). Pre-eclampsia was reported more frequently in women with migraine who gave birth to a child with CP or a perinatal death, particularly in those born preterm; OR ¼ 5.1 (1.3, 20) and OR ¼ 2.9 (1.1, 7.6), respectively, but not in women giving birth to a control whether term or preterm.Conclusion: Maternal migraine, as self-reported early in pregnancy, was associated with preterm birth in survivors without CP and in infants who died in the perinatal period. The combination of maternal migraine and pre-eclampsia was associated with CP and perinatal death. The association of maternal migraine with outcomes of pregnancy warrants further study.

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Migraine is a Risk Factor for Hypertensive Disorders in Pregnancy: A Prospective Cohort Study

Cited by 103 publications

References 38 publications

Guidelines for the Prevention of Stroke in Women

Guidelines for the Prevention of Stroke in Women

Migraine and pregnancy: an internet survey

Migraine and preterm birth

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