Migraine is a risk factor for sudden sensorineural hearing loss: A nationwide population-based study

Chu, Chia Huei; Liu, Chia Jen; Fuh, Jong Ling; Shiao, An Suey; Chen, Tzeng Ji; Wang, Shuu Jiun

doi:10.1177/0333102412468671

Cited by 58 publications

(63 citation statements)

References 29 publications

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“…In a large populationbased study in Taiwan, an association between migraine and hearing loss has recently been reported. 32 In addition, there have been previous reports of sudden hearing loss and migraine in Meniere's disease. [33][34][35][36] However, the hearing loss developed in migraine patients at an older age, and their family members did not have hearing loss.…”

Section: Discussionmentioning

confidence: 99%

A missense variant of the ATP1A2 gene is associated with a novel phenotype of progressive sensorineural hearing loss associated with migraine

Baek

Weigand

et al. 2014

Eur J Hum Genet

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Hereditary sensorineural hearing loss is an extremely clinical and genetic heterogeneous disorder in humans. Especially, syndromic hearing loss is subdivided by combinations of various phenotypes, and each subtype is related to different genes. We present a new form of progressive hearing loss with migraine found to be associated with a variant in the ATP1A2 gene. The ATP1A2 gene has been reported as the major genetic cause of familial migraine by several previous studies. A Korean family presenting progressive hearing loss with migraine was ascertained. The affected members did not show any aura or other neurologic symptoms during migraine attacks, indicating on a novel phenotype of syndromic hearing loss. To identify the causative gene, linkage analysis and whole-exome sequencing were performed. A novel missense variant, c.571G4A (p.(Val191Met)), was identified in the ATP1A2 gene that showed co-segregation with the phenotype in the family. In silico studies suggest that this variant causes a change in hydrophobic interactions and thereby slightly destabilize the A-domain of Na þ /K þ -ATPase. However, functional studies failed to show any effect of the p.(Val191Met) substitution on the catalytic rate of this enzyme. We describe a new phenotype of progressive hearing loss with migraine associated with a variant in the ATP1A2 gene. This study suggests that a variant in Na þ /K þ -ATPase can be involved in both migraine and hearing loss.

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Section: Discussionmentioning

confidence: 99%

A missense variant of the ATP1A2 gene is associated with a novel phenotype of progressive sensorineural hearing loss associated with migraine

Baek

Weigand

et al. 2014

Eur J Hum Genet

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“…In the migraine cohort study of Chu et al, [31] including migraine patients looking for active medical assistance and patient population gathered from National Health Insurance Research Database, migraine was founded related to increase of SNHL risk when two cohort were composed by minimalizing the difference as much as possible in terms of vascular risk factors such as accompanier major cardiovascular diseases and serebrovascular diseases. In Chu et al, [31] study, SNHL developed during the follow-up in 134 (0.3%) of 51.400 subjects, it also developed in 43 (0.4%) subjects of migraine cohort and 91 subjects of matched control cohort (Fisher exact test, P < 0.001).…”

Section: Discussionmentioning

confidence: 99%

Audiological evaluation of hearing levels in patients diagnosed with migraine

et al. 2015

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“…Genes such as DFNA5 could also play a role in the etiology of hearing loss while involving cancer [9]. Migraine as a risk contributor for hearing loss was recently observed in population-based studies and the clinical setting, although the quality of study designs including the consideration of covariates would need to be revisited [10][11][12]. The relationship of migraine and hearing loss was first described in a case report back in 1987 [13].…”

Section: Main Findingsmentioning

confidence: 99%

Chronic diseases and life events accounted for 2–18 % population attributable risks for adult hearing loss: UK Adult Psychiatric Morbidity Survey, 2007

Ivy¹

2015

Eur Arch Otorhinolaryngol

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Links between chronic diseases and hearing loss in adults have emerged. However, previous investigations were not complete, and the role of life events was unclear. Therefore, it was aimed to examine the relationships of common chronic diseases and life events and adult hearing loss in a country-wide and population-based study. Data were retrieved from UK Adult Psychiatric Morbidity Survey, 2007, being cross-sectional, including demographics, self-reported prior health conditions and hearing loss (ever and in the last 12 months), and several major life events. Analyses included Chi square test, t test, logistic regression model, and population attributable risk estimation. People who had prior health conditions including cancer, migraine, dementia, depression, cataracts, chronic bronchitis, allergy, bowel problem, bladder problem, arthritis, muscle problem or skin problem tended to report hearing loss than their counterparts. People who have experienced major life events including post-traumatic stress disorder, serious illness of close relatives, death of family, serious problems with friends, major financial crisis, valuables stolen, being bullied, violence at home, sexual abuse or running away from home were also more likely to experience ever hearing loss problem or that in the last 12 months. 2.0-13.1 % adult hearing loss could be delayed or prevented by managing chronic diseases while 4.1-18.1 % might be delayed or prevented by minimizing the negative effects of life events. Chronic diseases and life events were associated with hearing loss in adults. Better managing lifestyle to minimize detrimental impacts in future health and nursing programs would be suggested.

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Migraine is a risk factor for sudden sensorineural hearing loss: A nationwide population-based study

Abstract: This population-based study demonstrates that migraine is associated with an increased risk of idiopathic SSNHL, which, however, is a rare condition.

Cited by 58 publications

References 29 publications

A missense variant of the ATP1A2 gene is associated with a novel phenotype of progressive sensorineural hearing loss associated with migraine

A missense variant of the ATP1A2 gene is associated with a novel phenotype of progressive sensorineural hearing loss associated with migraine

Audiological evaluation of hearing levels in patients diagnosed with migraine

Chronic diseases and life events accounted for 2–18 % population attributable risks for adult hearing loss: UK Adult Psychiatric Morbidity Survey, 2007

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