Migraine in women with chronic pelvic pain with and without endometriosis

Karp, Barbara I.; Sinaii, Ninet; Nieman, Lynnette K.; Silberstein, Stephen D.; Stratton, Pamela

doi:10.1016/j.fertnstert.2010.11.037

Cited by 43 publications

(21 citation statements)

References 40 publications

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“…In addition, migraines were more frequently reported in women experiencing pelvic pain, a common symptom of endometriosis, than in women without pelvic pain (OR = 1.88, adjusting for endometriosis diagnoses). In a previous report, Karp et al concluded that pelvic pain was an independent predictor of migraine [22]. Indeed, our data compliment this conclusion and demonstrate that endometriosis is also an independent predictor of migraine (OR = 1.36; adjusting diagnoses of pelvic pain).…”

Section: Discussionsupporting

confidence: 90%

“…Nyholt et al proposed that common genetic influences might underlie the co-morbid relationship between the two diseases [21]. Despite these suggestive data, a recent study by Karp et al failed to find evidence that migraine headaches were more common in women with endometriosis than in women without the disease [22]. One explanation for these disparate results may be the differences in the size and scope of the study populations used in the various analyses.…”

Section: Introductionmentioning

confidence: 99%

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Women with Endometriosis Are More Likely to Suffer from Migraines: A Population-Based Study

Yang

Wang

et al. 2012

PLoS ONE

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Previous research suggests that a co-morbid relationship exists between migraine and endometriosis; however, results have been inconsistent. In addition, female hormones, which are important in the pathogenesis and management of endometriosis, have been reported to precipitate migraine attacks and may confound the results. The aim of this population-based cohort study was to explore the relationship between migraine and endometriosis in women of reproductive age (18–51 years). Data were derived from the National Health Insurance Research Database of Taiwan, which contains outpatient and inpatient records from 2000 to 2007. Our study cohort included 20,220 endometriosis patients and 263,767 controls without endometriosis. We analyzed the prevalence of migraine in these women as recorded during the eight years of the database. Our results found that patients with endometriosis were more likely to suffer migraine headaches compared to controls (odds ratio [OR], 1.70; 95% confidence interval [CI] [1.59, 1.82]; p<0.001). In addition, the co-morbid association between migraine and endometriosis remained significant after the data were controlled for age and frequently utilized hormone therapies (OR, 1.37; 95% CI, [1.27, 1.47]; p<0.001). The results of this cohort study support the existence of a co-morbid relationship between migraine and endometriosis, even after adjusting for the possible effects of female hormone therapies on migraine attacks.

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Section: Discussionsupporting

confidence: 90%

Section: Introductionmentioning

confidence: 99%

Women with Endometriosis Are More Likely to Suffer from Migraines: A Population-Based Study

Yang

Wang

et al. 2012

PLoS ONE

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“…The inconsistency of the relation between the presence or severity of pain with endometriosis lesion location, extent of disease, and lesion characteristics also emphasizes that pelvic pain is a symptom which may also arise in the setting of other regional pain syndromes such as migraines (27, 28), irritable bowel syndrome, painful bladder syndrome, and fibromyalgia (22, 29). These diseases each engage the nervous system in one of several mechanisms (22, 27).…”

Section: Discussionmentioning

confidence: 99%

Relating Pelvic Pain Location to Surgical Findings of Endometriosis

Hsu

Sinaii

Segars

et al. 2011

Obstetrics &Amp; Gynecology

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Objective To study whether pain location is related to lesion location in women with chronic pelvic pain and biopsy-proven endometriosis. Methods A secondary analysis was performed to compare self-reported pain location with recorded laparoscopy findings for location and characteristics of all visible lesions. All lesions were excised. Endometriosis was diagnosed using histopathology criteria. The pelvic area was divided into three anterior and two posterior regions. Lesion depth, number of lesions or endometriomas, and disease burden (defined as sum of lesion sizes, or single versus multiple lesions) were determined for each region. Data were analyzed using t-tests, Fisher’s exact tests, and logistic regression modeling, with p-values corrected for multiple comparisons using the step-down Bonferroni method. Results Women with endometriosis (n=96) had a lower body mass index (BMI), were more likely to be white, had more prior surgery, and had more frequent menstrual pain and incapacitation than chronic pain patients without endometriosis (n=37). Overall, few patients had deeply infiltrating lesions (n=38). Dysuria was associated with superficial bladder peritoneal lesions. Other lesions or endometriomas were not associated with pain in the same anatomic locations. Lesion depth, disease burden, and number of lesions or endometriomas were not associated with pain. Conclusion In this group of women with biopsy-proven endometriosis, few had deeply infiltrating lesions or endometriomas. Dysuria and midline anterior pain were the only symptoms associated with the location of superficial endometriosis lesions. The lack of relationship between pain and superficial lesion location raises questions about how these lesions relate to pain. Clinical Trial Registration ClinicalTrials.gov, www.clinicaltrials.gov, NCT00001848.

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“…According to Gelbaya and El-Halwagy [3], CPP is cause for approximately 40% of laparoscopies and 10% to 15% of hysterectomies. It is also an annoying disease that affect deeply and negatively woman’s quality of life: this considering also that CPP is often associated to migraine and headache, regardless if CPP is related or not to endometriosis [4]. Leserman et al [5], underlined that patients with diffuse abdominal/pelvic pain had more trauma and worse mental and physical health status compared with patients with vulvovaginal pain and cyclic pain, and also had poorer health than patients with neuropathic and fibroid pain.…”

Section: Introductionmentioning

confidence: 99%

Chronic Pelvic Pain in Endometriosis: An Overview

Triolo¹

2013

J Clin Med Res

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Chronic pelvic pain (CPP) could be considered nowadays a deep health problem that challenges physicians all over the world. This because its aetiology is still unclear, the course of the disease could vary a lot among different patients and through time in the same patient, and the response to treatments is not every time successful. Among women who underwent laparoscopy for CPP, endometriosis is found in about 1/3 of the cases, while only 25% of women with histological confirmed endometriosis are asymptomatic. A wide range of variables may exert their influence on the resulting pain syndrome in endometriosis; for example, score according to American society for reproductive medicine (rASRM), size of the sub-peritoneal and pelvic wall implants, Douglas obliteration, previous surgery. It is widely accepted nowadays that central nervous system (CNS) and peripheral nervous system (PNS) seems to influence each other and this interconnection play a key role in pain modulation. Moreover, the phenomena induced by endometriosis in the pelvis, including the breakdown of peritoneal homeostasis and the induction of the production of proinflammatory and proangiogenic cytokines, are responsible of altered innervations and modulation of pain pathways in these patients. There are many proposed medical and surgical approach to treat this painful syndrome, although there is necessity of more efforts to create new non-invasive strategies that set a more accurate diagnosis of the causes of endometriotic-related CPP, and therefore facilitate its eradication.

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Migraine in women with chronic pelvic pain with and without endometriosis

Cited by 43 publications

References 40 publications

Women with Endometriosis Are More Likely to Suffer from Migraines: A Population-Based Study

Women with Endometriosis Are More Likely to Suffer from Migraines: A Population-Based Study

Relating Pelvic Pain Location to Surgical Findings of Endometriosis

Chronic Pelvic Pain in Endometriosis: An Overview

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