Migraine and the risk of stroke

Dafer, Rima M.

doi:10.1016/j.disamonth.2015.03.004

Cited by 1 publication

(1 citation statement)

References 55 publications

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“…The risk of ischemic stroke in migraine patients may also be increased by cardiovascular risk factors, e.g., diabetes, hypertension, obesity and dyslipidemia [12], hyperhomocysteinemia, as well as genetic factors, e.g., C677T polymorphism in MTHFR, insertion/deletion polymorphism in ACE or mutations in NOTCH3 [13].…”

Section: Introductionmentioning

confidence: 99%

Migraine and Risk Factors of Vascular Diseases

Kowalska¹,

Wize²,

Wieczorek³

et al. 2018

Ischemic Stroke of Brain

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Migraine is a common neurological disease that affects both women and men in a different age. It is believed that migraine is a multifactorial disease with strong genetic and environmental factors. Current molecular studies in migraine are focused on biochemical (homocysteine, asymmetric dimethylarginine) and genetic (ACE, MTHFR, MTR, MTRR, CBS, eNOS, NOTCH3) risk factors associated with vascular diseases. Polymorphisms and mutations in mentioned genes predispose to migraine as well as cardiovascular diseases and stroke. According to the literature data, 13-15% of migraine with aura patients suffer from vascular diseases, too. The strict relation between migraine with aura and stroke is observed in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy. Lifestyle plays an important role both in the pathomechanism of migraine and vascular diseases. Hypertension, obesity, dyslipidemia, and diabetes mellitus are the important risk factors for those pathological conditions. Therefore, early diagnosis of migraine and the implementing effective pharmacotherapy can lead to the prevention of cardiovascular and cerebrovascular diseases.

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Section: Introductionmentioning

confidence: 99%