Migraine and Sudden Sensorineural Hearing Loss

Lipkin, Alan F.; Jenkins, Herman A.; Coker, Newton J.

doi:10.1001/archotol.1987.01860030101018

Cited by 44 publications

(29 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Previous reports have observed that migraine can lead to permanent auditory and vestibular deficits 11,26,[30][31] . It is common that migraine-related transitory neurological symptoms lasting more than four and less than 60 minutes can be considered to be aura.…”

Section: Discussionmentioning

confidence: 96%

“…In this situation, the acute stimulation of one of the otolith organs from the hydrops will produce drop attacks that may lead to confusion with vertebrobasilar insufficiency 25 . Migraine patients have reported the abrupt onset of a profound hearing loss [26][27][28] . Although some gradual improvement may occur, they are often left with a severe, unilateral, or bilateral 27 , sensorineural hearing loss.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Oscillucusis and sudden deafness in a migraine patient

Piovesan

Kowacs

Werneck

et al. 2003

Arq. Neuro-Psiquiatr.

View full text Add to dashboard Cite

-Migraine is a complex disease that includes neurologic, gastrointestinal and autonomic symptoms, although headache is most common feature. In a portion of cases headache is preceded by focal neurologic symptoms termed auras. Auditory symptoms only rarely occur as part of an aura. We describe a patient whose 13-year migraine history that included the abnormal perception an oscillation of the intensity of ambient sounds (oscillucusis). During a migraine attack immediately after oscillucusis, the patient developed acute and permanent sudden deafness. Clinical and neurologic examinations revealed only profound hearing loss in her left ear. Audiometric testing confirmed the sensorineural nature of the hearing loss. The clinical aspects and physiopathology of auditory symptoms in this case and in patients with migraine is reviewed.KEY WORDS: aura, headache, migraine, oscillucusis, sudden deafness.Oscilucusia e perda auditiva em um paciente com migranea. Oscilucusia e perda auditiva em um paciente com migranea. Oscilucusia e perda auditiva em um paciente com migranea. Oscilucusia e perda auditiva em um paciente com migranea. Oscilucusia e perda auditiva em um paciente com migranea.RESUMO -Migrânea é desordem complexa que inclui sintomas neurológicos, gastrointestinais e autonômicos, na qual a cefaléia é o achado predominante. Em uma parcela de pacientes o quadro álgico pode ser antecipado por sinais neurológicos focais conhecidos como aura. Descrevemos um paciente que iniciou sua historia de migrânea acompanhada por sensações de flutuações nos sons ambientes (oscillucusis) por treze anos. Durante uma crise de cefaléia imediatamente após a oscillucusia o paciente desenvolveu um quadro agudo e permanente de perda auditiva. Exames clínicos e neurológicos revelaram somente uma perda profunda da audição em ouvido esquerdo, cuja natureza sensorioneural foi confirmada por uma avaliação audiométrica. Os aspectos clinicos e fisiopatológicos dos sintomas auditivos encontrados neste caso e em pacientes com migrânea com aura são revisados e comentados. PALAVRAS-CHAVE: aura, cefaléia, migrânea, oscilucusia, perda súbita de audição. , the focal neurological phenomena that precede or accompany an attack are known as aura. These neurological manifestations include visual, somato-sensory, olfactory and less frequently auditory symptoms.The case of a migraine patient with auditory aura followed by hearing loss is revised, and the literature about auditory symptoms in migraine with aura patients are reviewed. CASEA 56-year-old woman started to present migraine episodes at age 40. An year later she perceived ambient sounds to be fluctuating in intensity (oscillucusis). This would last 50 minutes, and was followed by a unilateral (right or left side), throbbing headache associated with nausea and vomiting. These episodes lasted 18 hours, occurred at twice a month and were commonly triggered by stress. At age 53, she had the sudden onset of profound hearing loss in her left ear that was unassociated with vertigo or any other neuro...

show abstract

Section: Discussionmentioning

confidence: 96%

Section: Discussionmentioning

confidence: 99%

Oscillucusis and sudden deafness in a migraine patient

Piovesan

Kowacs

Werneck

et al. 2003

Arq. Neuro-Psiquiatr.

View full text Add to dashboard Cite

show abstract

“…32 In addition, there have been previous reports of sudden hearing loss and migraine in Meniere's disease. [33][34][35][36] However, the hearing loss developed in migraine patients at an older age, and their family members did not have hearing loss. Thus, it has not been clear whether the migraine and hearing loss share the same pathogenic cause in these cases.…”

Section: Discussionmentioning

confidence: 99%

A missense variant of the ATP1A2 gene is associated with a novel phenotype of progressive sensorineural hearing loss associated with migraine

Baek

Weigand

et al. 2014

Eur J Hum Genet

View full text Add to dashboard Cite

Hereditary sensorineural hearing loss is an extremely clinical and genetic heterogeneous disorder in humans. Especially, syndromic hearing loss is subdivided by combinations of various phenotypes, and each subtype is related to different genes. We present a new form of progressive hearing loss with migraine found to be associated with a variant in the ATP1A2 gene. The ATP1A2 gene has been reported as the major genetic cause of familial migraine by several previous studies. A Korean family presenting progressive hearing loss with migraine was ascertained. The affected members did not show any aura or other neurologic symptoms during migraine attacks, indicating on a novel phenotype of syndromic hearing loss. To identify the causative gene, linkage analysis and whole-exome sequencing were performed. A novel missense variant, c.571G4A (p.(Val191Met)), was identified in the ATP1A2 gene that showed co-segregation with the phenotype in the family. In silico studies suggest that this variant causes a change in hydrophobic interactions and thereby slightly destabilize the A-domain of Na þ /K þ -ATPase. However, functional studies failed to show any effect of the p.(Val191Met) substitution on the catalytic rate of this enzyme. We describe a new phenotype of progressive hearing loss with migraine associated with a variant in the ATP1A2 gene. This study suggests that a variant in Na þ /K þ -ATPase can be involved in both migraine and hearing loss.

show abstract

“…However, four patients reported short-lasting aural pressure during the episode. There is clinical evidence that migraine can damage the inner ear, leading to permanent hearing loss (Lipkin et al, 1987;Olsson, 1991). Cochlear symptoms such as hearing loss, tinnitus and sensations of aural fullness, sometimes mimicking Menière's disease, have been reported in MV (Kayan and Hood, 1984;Olsson, 1991).…”

Section: Cochlear Symptomsmentioning

confidence: 99%

Clinical Significance of Perverted Head-Shaking Nystagmus

Yang¹,

Shin²,

Seo³

et al. 2017

Res Vestib Sci

View full text Add to dashboard Cite

SummaryMigrainous vertigo (MV) is an increasingly recognized cause of episodic vertigo. However, the pathophysiology of MV is still a matter of speculation and it is not known to what extent the dysfunction is located in the central or peripheral vestibular system. The aim of this prospective study was to describe the clinical spectrum of acute MV and to clarify which structures of the vestibular system are involved. Testing of 20 patients with acute MV included neuro-otological examination, recording of spontaneous and positional nystagmus with 3D video-oculography, and audiometry. Pathological nystagmus was observed in 70% of patients during acute MV: six had isolated spontaneous nystagmus, five had isolated positional nystagmus and three had a combination of the two. Only a few patients showed additional ocular motor deficits. Imbalance was observed in all patients except one. Hearing was not affected in any patient during the attack. The findings during acute MV point to centralvestibular dysfunction in 10 patients (50%) and to peripheral vestibular dysfunction in three patients (15%). In the remaining seven patients (35%) the site of involvement could not be determined with certainty. MV should be considered in the differential diagnosis of vertigo with spontaneous and positional nystagmus and can present both as a central and a peripheral vestibular disorder.

show abstract

Migraine and Sudden Sensorineural Hearing Loss

Cited by 44 publications

References 5 publications

Oscillucusis and sudden deafness in a migraine patient

Oscillucusis and sudden deafness in a migraine patient

A missense variant of the ATP1A2 gene is associated with a novel phenotype of progressive sensorineural hearing loss associated with migraine

Clinical Significance of Perverted Head-Shaking Nystagmus

Contact Info

Product

Resources

About