Background:-University studentsare routinelycomplaining of triggers, especiallyirregular sleepand stress, which are commonly associated with migraineattacks. Objectives:-To assess the prevalenceof migraine headache among female students at Taibah University (Saudi Arabia) and to determine the common triggering and palliative factors of migraine headache among female University students. Methods:-A cross-sectional study was carried out among female university students.Participants who had suffered from two or more headaches in the previous 3 months were subjected to the IDMigraine screening test, then who had at least two positive answers of the screening test were confirmed as a migraineursbased on the diagnostic criteria of the International Headache Society for migraine. Results:-Migraine was detected among 244 out of 395 students (61.8%).Physical stimulation as (light, loudness, change in weather, certain smells) were the most triggering factors of migraine in 170/244 (69.7%) of migraine students. The most important relieving factors were rest and sleep in 155/244 (63.5%), medication in (33.2%), followed by darkening room in (30.3%), message in (20.1%), and coffee drink in (18%) of migraine students. This study showed significant association between migraine headache and family history of migraine and studying in theoretical colleges. Conclusions:-The prevalenceof migraine among female students in Taibah University was high in comparison to other studies. The study recommend raising awareness towards migraine among students and teaching them how to deal with such a disabling condition to achieve optimum coping techniques aiming to a better quality of life.Copy Right, IJAR, 2013,. All rights reserved.