Migraine: A disorder of metabolism?

Kokavec, Anna

doi:10.1016/j.mehy.2016.10.029

Cited by 17 publications

(21 citation statements)

References 237 publications

(323 reference statements)

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“…Nevertheless, when artificially introduced in food, it can have excitotoxic effects ( 51 ). Aspartame might significantly impair the release of 5-HT in the brain ( 52 ). “It can increase the supply of phenylalanine, which subsequently can promote a decrease in Trp uptake by brain tissue or a depression in Trp conversion to 5-HT” ( 52 ).…”

Section: Discussionmentioning

confidence: 99%

“…Stress may also provoke similar effect activating the same biochemical pathway, contributing in the exacerbation of patient conditions: besides estrogens, indeed, TDO is inducible by Trp itself and glucocorticoids ( 53 ). The glucocorticoid cortisol is rapidly release in response to emotional stress, stimulating the Trp-KYN pathway activity ( 52 ), once more reducing the availability of Trp for 5-HT synthesis.…”

Section: Discussionmentioning

confidence: 99%

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Fibromyalgia Syndrome: A Metabolic Approach Grounded in Biochemistry for the Remission of Symptoms

Lattanzio

2017

Front. Med.

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Fibromyalgia syndrome (FMS) is a chronic, complex, and heterogeneous disorder of still poorly understood etiopathophysiology associated with important musculoskeletal widespread pain, fatigue, non-restorative sleep, and mood disturbances. It is estimated to afflict 2–3% of the worldwide population, with clean prevalence among women. The objective of this paper is to propose a novel treatment for symptomatic remission of FMS, grounded in biochemistry and consisting in the withdrawal from the diet of molecules that can indirectly trigger the symptoms. The hypothesis develops from the evidence that low serotonin levels are involved in FMS. Serotonin is synthesized starting from the essential amino acid tryptophan. The presence of non-absorbed molecules in the gut, primarily fructose, reduces tryptophan absorption. Low tryptophan absorption leads to low serotonin synthesis that triggers FMS symptoms. Moreover not-absorbed sugars could also produce a microbiota deterioration activating a positive feedback loop: the increasing microbiota deterioration reduces the functionality of absorption both of fructose and tryptophan in the gut, entering a vicious circle. The therapeutic idea is to sustain serotonin synthesis allowing the proper tryptophan absorption. The core of the cure treatment is the exclusion from the diet of some carbohydrates and the marked reduction of some others. The main target is the limitation of total dietary fructose as marked as possible. It could be an effective strategy to get the remission of symptoms acting on the impaired biochemical pathways. The straying from the treatment is expected to cause the reappear of the symptoms.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Fibromyalgia Syndrome: A Metabolic Approach Grounded in Biochemistry for the Remission of Symptoms

Lattanzio

2017

Front. Med.

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“…Additionally, researchers have not been able to identify a set of common triggers between patients. In the literature, migraine triggers have been classified into nutritional, environmental, behavioral, hormonal, and psychological ( Table 1) [1]. In clinical practice, the most common triggers that are encountered include fasting, skipping meals, sleep deprivation, and emotional stress.…”

Section: Reviewmentioning

confidence: 99%

“…Therefore, in the absence of a physiological stimulus (migraine), increased lactate levels can be considered pathological [4]. It has also been suggested that elevated levels of free fatty acids and ketone bodies have been detected before a migraine attack [1]. An elevation in concentrations of growth hormone, glycerol, and cortisol are also seen during an attack [1].…”

Section: Reviewmentioning

confidence: 99%

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Therapeutic Implications of Altered Energy Metabolism in Migraine: A State-of-the-Art Review

Hassan

Farooque

Choudhry

et al. 2020

Cureus

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Currently, the management strategies aimed at the resolution of migraine are pharmacological. Most of these therapies are known to alter the serotonin balance of the brain. Furthermore, therapies blocking the calcitonin gene-related peptide (CGRP) have also proven to be quite effective in their treatments. However, apart from being expensive, these therapies do not influence premonitory and aura symptoms. This suggests an incomplete approach and an inadequate understanding of the migraine pathophysiology. Recent metabolic studies have indicated that migraine should be considered as an adaptive response to the mismatch between the cerebral energy reserves and expenditure. Therefore, understanding the underlying metabolism helps derive possible novel therapeutic modalities for migraines. In this review, we highlight the underlying metabolic abnormalities found in migraine patients. This will form the basis of our evidence-based discussion on metabolic therapeutic options for migraines.

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Nutritional Approach to the Common Symptoms of Flammer Syndrome

Shapira

2019

Flammer Syndrome

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Migraine: A disorder of metabolism?

Cited by 17 publications

References 237 publications

Fibromyalgia Syndrome: A Metabolic Approach Grounded in Biochemistry for the Remission of Symptoms

Fibromyalgia Syndrome: A Metabolic Approach Grounded in Biochemistry for the Remission of Symptoms

Therapeutic Implications of Altered Energy Metabolism in Migraine: A State-of-the-Art Review

Nutritional Approach to the Common Symptoms of Flammer Syndrome

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