Mifepristone With Buccal Misoprostol for Medical Abortion

Abstract

OBJECTIVE:To summarize clinical outcomes and adverse effects of medical abortion regimens consisting of mifepristone followed by buccal misoprostol in pregnancies through 70 days of gestation.

Comparing office and telephone follow-up after medical abortion

“…Although the medical abortion efficacy rates were similar in both groups, the overall efficacy is lower (93.4%) compared to what we expected using evidence-based regimens [1,2,16]. The ongoing pregnancy rate of 1.2% is similar to previous studies; however, the incomplete abortion rate in this study was higher.…”

Medical abortion reporting of efficacy: the MARE guidelines

“…These issues became evident during data collation for creation of the 2014 Medical Management of First Trimester Abortion Practice Bulletin written collaboratively by the American College of Obstetricians and Gynecologists and the Society of Family Planning [6,7]. More recently, a systematic review including approximately 30,000 patients who received mifepristone and buccal misoprostol found that only 57% had data identifying week of gestation for a stratified evaluation of overall efficacy; only 51% had such information for evaluation of continuing pregnancy [9].…”

Predictors of uterine evacuation following early medical abortion with mifepristone and misoprostol

“…With a regimen of mifepristone and vaginal misoprostol, approximately 3% to 5% of women will subsequently undergo uterine evacuation [1][2][3]. Regimens using mifepristone and buccal misoprostol have a similar (3.3%) risk of requiring uterine evacuation [4,5]. In approximately 2%-3% of women, uterine evacuations are performed after expulsion of the pregnancy due to pain or bleeding [1][2][3]5].…”

“…Regimens using mifepristone and buccal misoprostol have a similar (3.3%) risk of requiring uterine evacuation [4,5]. In approximately 2%-3% of women, uterine evacuations are performed after expulsion of the pregnancy due to pain or bleeding [1][2][3]5].…”