Mifepristone–misoprostol midtrimester abortion: impact of gestational age on the induction-to-abortion interval

Dosing interval of 24 hours versus 48 hours between mifepristone and misoprostol administration for mid-trimester termination of pregnancy

“…In addition, abortion was faster among women with a pregnancy duration of less than 16 weeks than among those with a longer pregnancy duration, but the difference reached significance in the group with the conventional dosing interval only. Nulliparity and a longer pregnancy duration were also associated with a longer induction‐to‐abortion interval in most other studies [9–12]. In accordance with the literature [9–12], there were no major complications in either group.…”

“…The participants were stratified into 2 subgroups according to the duration of pregnancy (less than 16 weeks and 16 weeks or more). This ensured an even distribution of participants because pregnancy duration is 1 of 2 important variables (the other being parity) affecting the induction‐to‐abortion interval [12].…”

Mifepristone–Misoprostol Dosing Interval and Effect on Induction Abortion Times

“…33 The only 24-hour interval study using a 200-microgram misoprostol dosing (400 micrograms buccal misoprostol followed by 200 micrograms buccal every 6 hours) reported similar results as the longer interval studies at this dosage with a median induction time of 10 hours and 97% expelled by 24 hours. 21,[36][37][38][39][40][41] The two remaining observational studies used 400 micrograms misoprostol every 3-6 hours. One retrospective cohort showed a significant difference between 1-day and 2-day mifepristone-misoprostol intervals, using misoprostol 400 micrograms vaginally every 3 hours, with median induction times of 9.8 compared with 7.5 hours, respectively (P,.01) with no difference in the percent expelled at 24 hours.…”

“…With total abortion times (mifepristone to expulsion), the wait time between mifepristone and misoprostol warrants consideration, because it strongly correlates with total time (Fig. 23,24,35,36,40,41 This should be considered when applying results to higher gestational ages and patients should be counseled appropriately. For example, Chai et al 22 reported the overall success rate for abortion 24 hours after first misoprostol administration was 91.5% for immediate misoprostol dosing compared with 100% in the 36-to 38-hour group.…”

Feticide Followed by Mifepristone-Misoprostol Regimen for Midtrimester Termination of Pregnancy in Two Cases of Complete Placenta Previa

“…In our first case, the induction-to-abortion interval was 17 h, and a surgical evacuation of the uterus was needed because of a retained placenta. We recently reported that increased gestational age at TOP is associated with a longer induction interval and a lower proportion of patients delivering within 12 h [13] . In that study, 20 weeks' gestation was the best cutoff to discriminate this risk.…”