Mifepristone and misoprostol in the induction of labor at term

McGill, John; Shetty, Asha P

doi:10.1016/j.ijgo.2006.09.030

Cited by 18 publications

(22 citation statements)

References 14 publications

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“…In our study, we observed that mifepristone is associated with favorable outcome in 89 % of women (labor onset in 56 % and cervical ripening 33 %) within 48 h of administration of oral mifepristone. These observations are in accordance with the existing literature where a variable success rate of labor onset at 66-93 % has been observed in pregnant women [8][9][10][11][12][13][14][15]. Also, the effect of cervical ripening after use of mifepristone has been variable ranging from no statistically difference to statistically significant improvement (60-80 % of all cases) [16][17][18][19][20].…”

Section: Discussionsupporting

confidence: 90%

A Retrospective Case–Control Study Evaluating the Role of Mifepristone for Induction of Labor in Women with Previous Cesarean Section

Sharma

Soni

et al. 2015

J Obstet Gynecol India

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Objective To investigate the role of ''mifepristone'' for induction of labor (IOL) in pregnant women with prior cesarean section (CS).Methods In this retrospective study, all pregnant women with prior CS who received oral mifepristone (400 mg) for IOL (as per clear obstetric indications) [group 1] were compared with pregnant women with prior CS who had spontaneous onset of labor (SOL) [group 2], with respect to incidence of vaginal delivery, CS, duration of labor, and various maternal and fetal outcomes. Results During the study period, 72 women received mifepristone (group 1) for IOL and 346 had SOL (group 2). In group 1 after mifepristone administration, 40 (55.6 %) women had labor onset, and 24 (33.3 %) women had cervical ripening (Bishop Score C 8) within 48 h. There were no statistically significant differences with respect to duration of labor (p value: 0.681), mode of delivery (i.e., normal delivery or CS-p value: 0.076 or 0.120, respectively), or maternal (blood loss or scar dehiscence/rupture uterus), or fetal outcomes (NICU admission) compared to women with previous CS with SOL (group 2). However,

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Section: Discussionsupporting

confidence: 90%

A Retrospective Case–Control Study Evaluating the Role of Mifepristone for Induction of Labor in Women with Previous Cesarean Section

Sharma

Soni

et al. 2015

J Obstet Gynecol India

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“…Remaining 68% Women required Misoprostol for induction of labor .Out of that 56% delivered virginally, which quite low compare to study is done by Li L 10 who found 80% delivered vaginally.44% required cesarean section. J. Mcgill 11 found rate of cesarean section was higher in women who required T. Mifeprostol followed by T. Misoprostol.…”

Section: Discussionmentioning

confidence: 98%

“…J McGill et al 11 found 66% women went in labor without T. Misoprostol. Elliot CL et al 7 found in their conclusion that T. Mifeprostol is known to cause softening and dilatation of cervix and increase in uterine activity.…”

Section: Discussionmentioning

confidence: 98%

Comparative Analysis of Safety, Efficacy and Fetomaternal Outcome of Induction of Labor With Tablet Mifepristone and Tablet Misoprostol Versus Tablet Misoprostol

Ashtekar¹,

Shilpa²,

Amrapali³

et al. 2014

jemds

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OBJECTIVES:The present study aims at comparing the efficacy, safety and fetomaternal outcome of Misoprostol as cervical ripening and labor inducing agent versus Mifepristone and Misoprostol. The study also aims to observe the improvement in pre induction Bishop's score, proportion of patients going in labor, to study induction-delivery interval. METHODS: It is randomized prospective studies conducted on 100 women. Women were randomized in group A and in group B of 50 patients in each group. Group A received tab Mifepristone 200 mg orally on day 1 followed by tablet Misoprostol 25 mcg after 48 hours and continued 4 hrly till patient went in active labor with maximum four tablets and group B patients received tablet Misoprostol 25mcg and continued 25mcg 4hrly till patient went in active labor. RESULTS: The study demonstrated significant efficacy of tablet Mifepristone for cervical ripening and induction of labor as pre induction Bishop's score was improved. 32%patients went into labor only with tablet Mifepristone. The mean induction-delivery interval was 9.5 hrs in Group A and 11.78 hrs in Group B, 40% patients delivered by cesarean section in group A but it was not associated with any differences in final neonatal outcome in both the groups. Uterine hyper stimulation was present in 42% patients in group A as compared to only 20% patients in group B. Fetal distress was present in 38% of patients in group A as compared to 18% patients in group B. No any difference in final neonatal outcome was observed in both the groups. CONCLUSION: Mifepristone pretreatment is more efficacious and significantly shortens the induction-delivery interval and it has got dual role as a cervical ripening and labor inducing agent.

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“…According to various existing literature, the labor onset and cervical ripening observed. [8][9][10][11][12] There is need of oxytocin requirement for augmentation of labour is very minimum so there is very less chances of scar dehiscence and rupture uterus. Mifepristone initiate the labour as naturally, causes cervical ripening (by releasing NO),promote uterine contractions by forming gap junctions and increasing influx of calcium it also increases the prostaglandins release without acting as a direct uterotonic.…”

Section: Discussionmentioning

confidence: 99%

Role of mifepristone in induction of labour in pregnant women with previous lower section caesarean section with IUFD in late preterm and term pregnancies

Deora

Shetty

2017

Int J Reprod Contracept Obstet Gynecol

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Background: The objective of the study was to evaluate efficacy and safety of oral mifepristone for preinduction cervical ripening and induction of labour in late preterm and term pregnancies with previous caesarean section with intrauterine fetal demiseMethods: This prospective short term study was conducted at Umaid hospital SNMC Jodhpur Rajasthan January 2016 to November 2016. 100 subjects with previous uses beyond 34 week with intrauterine fetal demise and bishop’s score<6 were included. Tablet mifepristone 200mg was given orally after taking written in informed consent. The same dose was repeated after 24 hour according to bishop’s score. Analysis was done with respect to maternal outcome of vaginal delivery, CS, duration of labour.Results: Among 100 subjects, 97 delivered vaginally (97%) delivered within 72 hour of 1% dose. Improvement of bishop’s score was observed in 1 subject (1%), which later required augmentation by oxytocin followed by vaginal delivery.1 subject (2%) failed to respond and required caesarean section, 72 hour after given of 1st dose.Conclusions: Mifepristone can be used safely and effectively for induction of labour in previous one and two LSCS near term and term pregnancies to avoid CS rates.

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Mifepristone and misoprostol in the induction of labor at term

Cited by 18 publications

References 14 publications

A Retrospective Case–Control Study Evaluating the Role of Mifepristone for Induction of Labor in Women with Previous Cesarean Section

A Retrospective Case–Control Study Evaluating the Role of Mifepristone for Induction of Labor in Women with Previous Cesarean Section

Comparative Analysis of Safety, Efficacy and Fetomaternal Outcome of Induction of Labor With Tablet Mifepristone and Tablet Misoprostol Versus Tablet Misoprostol

Role of mifepristone in induction of labour in pregnant women with previous lower section caesarean section with IUFD in late preterm and term pregnancies

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