MIF in the cerebrospinal fluid is decreased during relapsing-remitting while increased in secondary progressive multiple sclerosis

Hjæresen, Simone; Sejbæk, Tobias; Axelsson, Markus; Mortensen, Sif Kløvedal; Vinsløv-Jensen, Helle; Pihl-Jensen, Gorm; Novakova, Lenka; Pedersen, Christian Bonde; Halle, Bo; Poulsen, Frantz Rom; Zhang, Mengliang; Benedikz, Eiríkur; Frederiksen, Jette; Lycke, Jan; Illés, Zsolt; Svenningsen, Åsa Fex

doi:10.1016/j.jns.2022.120320

Cited by 7 publications

(4 citation statements)

References 67 publications

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“…The Markov Chain Monte Carlo (MCMC) method was used to assess the sensitivity indices between inflammaging and MS. As a result, the 35 sensitive triples (by calculating the absolute difference frequency) were shown in Table 3 (Sarasin-Filipowicz et al, 2009 ; Chen and D'Mello, 2010 ; Bergbold and Lemberg, 2013 ; Liu et al, 2013 ; Malhotra et al, 2013 ; Wan, 2014 ; Charbit et al, 2015 ; Fusco et al, 2015 ; An et al, 2017 ; Arentsen et al, 2017 ; Maridas et al, 2017 ; Mathur et al, 2017 ; Xiao et al, 2019 ; Immler et al, 2020 ; Sato et al, 2020 ; Tong et al, 2020 ; Buhelt et al, 2021 ; Correale, 2021 ; Fadul et al, 2021 ; Ma et al, 2021 ; Peng et al, 2021 ; Bogacka et al, 2022 ; Franceschi et al, 2022 ; Hjæresen et al, 2022 ; Khurana and Goswami, 2022 ; Liu S. et al, 2022 ; Schebb et al, 2022 ; Watanabe et al, 2022 ; Saeidi et al, 2023 ). For example, the sensitive triple with maximum difference was “TMPRSS13-USP18-DCHS2” (the absolute difference value was 0.270469).…”

Section: Resultsmentioning

confidence: 99%

Identification of crucial inflammaging related risk factors in multiple sclerosis

Xu,

Wang,

Ren

et al. 2024

Front. Mol. Neurosci.

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BackgroundMultiple sclerosis (MS) is an immune-mediated disease characterized by inflammatory demyelinating lesions in the central nervous system. Studies have shown that the inflammation is vital to both the onset and progression of MS, where aging plays a key role in it. However, the potential mechanisms on how aging-related inflammation (inflammaging) promotes MS have not been fully understood. Therefore, there is an urgent need to integrate the underlying mechanisms between inflammaging and MS, where meaningful prediction models are needed.MethodsFirst, both aging and disease models were developed using machine learning methods, respectively. Then, an integrated inflammaging model was used to identify relative risk factors, by identifying essential “aging-inflammation-disease” triples. Finally, a series of bioinformatics analyses (including network analysis, enrichment analysis, sensitivity analysis, and pan-cancer analysis) were further used to explore the potential mechanisms between inflammaging and MS.ResultsA series of risk factors were identified, such as the protein homeostasis, cellular homeostasis, neurodevelopment and energy metabolism. The inflammaging indices were further validated in different cancer types. Therefore, various risk factors were integrated, and even both the theories of inflammaging and immunosenescence were further confirmed.ConclusionIn conclusion, our study systematically investigated the potential relationships between inflammaging and MS through a series of computational approaches, and could present a novel thought for other aging-related diseases.

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Section: Resultsmentioning

confidence: 99%

Identification of crucial inflammaging related risk factors in multiple sclerosis

Xu,

Wang,

Ren

et al. 2024

Front. Mol. Neurosci.

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“…A more recent study showed increased levels of MIF both in CSF and in serum of RRMS patients [ 49 ]. In contrast, the study by Hjaeresen et al shows that MIF is decreased during RRMS and increased in SPMS [ 50 ]. Additionally, MIF levels were significantly decreased in females with CIS and RRMS as compared to males suggesting sex-dependent regulation of MIF production.…”

Section: Multiple Sclerosismentioning

confidence: 94%

“…Drugs such as monomethyl fumarate (MMF), a product of dimethyl fumarate (DMF) hydrolysis after absorption inside the small intestine and MTX (mitoxantrone) have only limited access to the CNS. Thus, these drugs would likely have little influence on MIF levels in CNS-resident cells and limited effect on increased MIF levels in CSF as found in RRMS patients [ 50 ]. A newer anti-inflammatory drug, ibudilast, a non-selective inhibitor of various cyclic nucleotide phosphodiesterases often used as a bronchodilator for bronchial asthma treatment, plays a central role in processes like inflammation and synaptic plasticity.…”

Section: Multiple Sclerosismentioning

confidence: 99%

MIF contribution to progressive brain diseases

Matejuk,

Benedek,

Bucala

et al. 2024

J Neuroinflammation

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Progressive brain diseases create a huge social and economic burden on modern societies as a major cause of disability and death. Incidence of brain diseases has a significantly increasing trend and merits new therapeutic strategies. At the base of many progressive brain malfunctions is a process of unresolved, chronic inflammation. Macrophage migration inhibitory factor, MIF, is an inflammatory mediator that recently gained interest of neuro-researchers due to its varied effects on the CNS such as participation of nervous system development, neuroendocrine functions, and modulation of neuroinflammation. MIF appears to be a candidate as a new biomarker and target of novel therapeutics against numerous neurologic diseases ranging from cancer, autoimmune diseases, vascular diseases, neurodegenerative pathology to psychiatric disorders. In this review, we will focus on MIF’s crucial role in neurological diseases such as multiple sclerosis (MS), Alzheimer’s disease (AD) and glioblastoma (GBM).

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“…Related to the former mechanism, the authors propose that male T cells may contribute to a more pro-inflammatory state ( 3 ). They also suggest, related to the latter mechanism, astrocytes may be more reactive in males, causing reactive gliosis ( 4 ). Males also have a higher likelihood of active rim lesions and greater iron accumulation in deep gray matter ( 5 ).…”

mentioning

confidence: 99%

Editorial: Understanding sex-specific issues in MS and its animal models: natural history, management and mechanisms

Zeydan,

Rangachari,

Kantarci

2024

Front. Neurol.

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MIF in the cerebrospinal fluid is decreased during relapsing-remitting while increased in secondary progressive multiple sclerosis

Cited by 7 publications

References 67 publications

Identification of crucial inflammaging related risk factors in multiple sclerosis

Identification of crucial inflammaging related risk factors in multiple sclerosis

MIF contribution to progressive brain diseases

Editorial: Understanding sex-specific issues in MS and its animal models: natural history, management and mechanisms

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