2020
DOI: 10.1182/blood.2020005795
|View full text |Cite
|
Sign up to set email alerts
|

MIF as a biomarker and therapeutic target for overcoming resistance to proteasome inhibitors in human myeloma

Abstract: Multiple myeloma (MM) remains largely incurable despite significant advances in bio- and chemotherapy. The major problem in MM management is development of drug resistance. Macrophage migration inhibitory factor (MIF) expression was significantly higher in purified MM cells from relapsed patients than those with sustained response, and high MIF MM patients had significantly shorter progression-free survival (PFS) and overall survival (OS). MM cell lines also express high levels of MIF, and knocking out MIF mad… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
2
1

Citation Types

3
30
0

Year Published

2020
2020
2024
2024

Publication Types

Select...
8

Relationship

0
8

Authors

Journals

citations
Cited by 36 publications
(33 citation statements)
references
References 76 publications
(77 reference statements)
3
30
0
Order By: Relevance
“…It is highlighted that MIF promotes progress and metastasis of various solid tumors, via activating downstream proliferation and anti-apoptotic signaling, regulating VEGF-mediated angiogenesis, inhibiting tumor suppressor P53, inducing immunosuppressive microenvironment and so on (36)(37)(38)(39)(40)(41)(42)(43). Pathogenic role of MIF has also been identified in MM, and its expression level may serve as a surrogate for disease progression and prognosis (18,34,(44)(45)(46). Recently, Wang et al reported that MIF was implicated in proteasome inhibitor resistance by maintaining superoxide dismutase 1 (SOD1) activity and mitochondrial function (44).…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…It is highlighted that MIF promotes progress and metastasis of various solid tumors, via activating downstream proliferation and anti-apoptotic signaling, regulating VEGF-mediated angiogenesis, inhibiting tumor suppressor P53, inducing immunosuppressive microenvironment and so on (36)(37)(38)(39)(40)(41)(42)(43). Pathogenic role of MIF has also been identified in MM, and its expression level may serve as a surrogate for disease progression and prognosis (18,34,(44)(45)(46). Recently, Wang et al reported that MIF was implicated in proteasome inhibitor resistance by maintaining superoxide dismutase 1 (SOD1) activity and mitochondrial function (44).…”
Section: Discussionmentioning
confidence: 99%
“…Pathogenic role of MIF has also been identified in MM, and its expression level may serve as a surrogate for disease progression and prognosis (18,34,(44)(45)(46). Recently, Wang et al reported that MIF was implicated in proteasome inhibitor resistance by maintaining superoxide dismutase 1 (SOD1) activity and mitochondrial function (44). In that sense, MIF High MM cells seem to be associated with more aggressive tumor behavior.…”
Section: Discussionmentioning
confidence: 99%
“…These results are indicative that, like hCCS, MIF-catalysed SOD1 disulphide formation is not wholly responsible for the SOD1 chaperone role. Preventing MIF trimer dissociation through an engineered inter-subunit disulphide between Cys80 and a mutated Asn110Cys site [48] does, however, consistently reduce mutant SOD1 misfolding and related cell death [44,47]. Trimeric MIF appears, therefore, to be the chaperone active species.…”
Section: Macrophage Migration Inhibitory Factormentioning
confidence: 94%
“…MIF is constitutively expressed by many tissue types including motor system cells but is conspicuously absent from neuronal cell bodies despite high-level MIF mRNA transcription [41,42]. In the absence of MIF, misfolded mutant SOD1 deposits are found on the cytoplasmic surface of mitochondria while, conversely, overexpression of MIF reduces mutant SOD1 association with both endoplasmic reticulum and mitochondrial membranes thereby maintaining mitochondrial function [42][43][44]. This translates into increased survival of mutant SOD1 expressing motor neurons when MIF production is increased.…”
Section: Macrophage Migration Inhibitory Factormentioning
confidence: 99%
“…In fact, although M2 macrophages can be detected in BM from MM independently of the stage disease, the grade of infiltration and its correlation with poor prognosis is notable within relapsed MM patients compared to patients with MGUS or SMM [ 138 , 145 ]. In line with these data, some serum receptors such as soluble CD206 and CD163, as well as chemokines like CCL2 and MIF have been proposed as biomarkers for disease progression, prognosis and treatment response [ 38 , 146 , 147 , 148 ].…”
Section: Myeloid Cells Involved In MM Progressionmentioning
confidence: 97%