Mie scattering and surface plasmon based spectroscopy for the detection of nanoparticle–protein interactions

Doyle, Gillian; Ashall, B.; Galvin, M.; Berndt, Michael; Crosbie, Stephen; Zerulla, Dominic

doi:10.1007/s00339-007-4126-2

Cited by 15 publications

(13 citation statements)

References 9 publications

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“…Surface plasmon resonance (SPR) optical effects are dependent upon shape, diameter, surface adsorbates, and distance between plasmonic particles [61]. Consequently, gold/silver nanoparticles –currently most commonly studied -- are routinely sized by measuring the extinction wavelength(s) of incident light [62, 63] Platinum, palladium, copper and other metals also possess plasmonic optical properties if protected from substantial contaminating oxides (i.e., copper nanoparticles within silica nanoshells) [64]. Importantly, plasmon peak absorbance progressively decreases in intensity and red shifts to higher optical wavelengths as the average particle diameter increases [65].…”

Section: Introductionmentioning

confidence: 99%

“…Colloid stability decreases with increasing salt concentration as Debye length-dependent electrostatic particle-particle repulsions decrease below the order of attractive van der Waals interactions [63]. Also, charge-stabilized or charged ligand-stabilized particles will aggregate rapidly in the presence of an oppositely charged protein (such as the aggregation of lysine-capped gold nanoparticles by human serum albumin (HSA) [70].…”

Section: Introductionmentioning

confidence: 99%

“…Loose adsorbates and unwanted solutes in nanoparticle systems are typically removed by dialysis [74] or centrifugation [63]. Loose particle aggregates are often broken up by bath sonication of the nanoparticle solution [68, 75].…”

Section: Introductionmentioning

confidence: 99%

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In vitro assessments of nanomaterial toxicity

Jones

Grainger

2009

Advanced Drug Delivery Reviews

500

321

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

In vitro assessments of nanomaterial toxicity

Jones

Grainger

2009

Advanced Drug Delivery Reviews

500

321

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“…Sensing based on scattering detections was reported in recent years [215][216][217][218]. In 2003, Roll et al suggested the resonant Raleigh scattering detection approach for solution phase molecules using the light scattering properties of colloids with LED irradiation [215].…”

Section: Localized Spr Biosensorsmentioning

confidence: 99%

Surface plasmon resonance based biosensor technique: A review

Guo

2012

Journal of Biophotonics

384

223

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Optical Surface plasmon resonance (SPR) biosensors represent the most advanced and developed optical label‐free biosensor technology. Optical SPR biosensors are a powerful detection and analysis tool that has vast applications in environmental protection, biotechnology, medical diagnostics, drug screening, food safety and security. This article reviews the recent development of SPR biosensor techniques, including bulk SPR and localized SPR (LSPR) biosensors, for detecting interactions between an analyte of interest in solution and a biomolecular recognition. The concepts of bulk and localized SPs and the working principles of both sensing techniques are introduced. Major sensing advances on biorecognition elements, measurement formats, and sensing platforms are presented. Finally, the discussions on both biosensor techniques as well as comparison of both SPR sensing techniques are made. (© 2012 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)

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“…Typical values for the sintering temperature reported in literature are in the range of 450–600 °C. Some of the new directions in DSC research, including low energy manufacturing, usage of flexible plastic electrodes, and integration of metallic nanoparticles [19]–[21], metallic nanostructured substrates [22] or quantum dots [23], require a decrease in the TiO 2 sintering temperature. Therefore there is a clear demand in understanding how the sintering process will be affected when modifying its parameters and how can the sintering be optimised to yield maximum DSC efficiency.…”

Section: Introductionmentioning

confidence: 99%

Optimisation of Ruthenium Dye Sensitised Solar Cells Efficiency via Sn Diffusion into the TiO2 Mesoporous Layer

Andrei

Zerulla

2013

PLoS ONE

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Dye sensitised solar cells (DSCs) typically include a mesoporous titanium dioxide (TiO2) scaffold, sensitised with an adsorbed dye, as the main active element responsible for the photon absorption and charge separation functionalities. The sintering process employed in the TiO2 active layer fabrication plays a crucial role in the formation of the nanoparticle (NP) scaffold and hence in the performance of a dye sensitised solar cell, as it allows the particles to form efficient inter-crystalline electric contacts providing high electron conductivity. Furthermore, the DSC design requires a conductive transparent top electrode which is typically made of fluorinated stannic oxide. Here we report on a highly spatially resolved scanning electron microscopy study in conjunction with focussed ion beam milling and energy dispersive X-ray (EDX) mapping of the distribution of all relevant elements within a DSC subsequent to a classical sintering process in the range of 350°C–550°C. Additionally, the article provides quantitative results regarding the found Sn diffusion and its effect on efficiency confirmed via J-V measurements. The effective spatial resolution of the EDX studies was calculated by Monte Carlo simulations of the electron trajectories and X-ray emission region. This permits to construct a model for the migration of Sn from the transparent conductive oxide into the TiO2 scaffold, resulting in alterations in the composition of the complex system which has a direct effect on the DSC performance. J-V measurements conclude that sintering temperature of 500°C is close to the optimum regarding Sn diffusion enhancement of DSCs. Sintering temperatures above 500°C were causing a drop in the DSC efficiency and are therefore not recommended. In order to optimize the DSC efficiency, the results are summarized by a model that explains how the efficiency varies with the Sn diffusion process.

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Mie scattering and surface plasmon based spectroscopy for the detection of nanoparticle–protein interactions

Cited by 15 publications

References 9 publications

In vitro assessments of nanomaterial toxicity

In vitro assessments of nanomaterial toxicity

Surface plasmon resonance based biosensor technique: A review

Optimisation of Ruthenium Dye Sensitised Solar Cells Efficiency via Sn Diffusion into the TiO2 Mesoporous Layer

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