Midterm results of conjunctival reconstruction with buccal mucosa and amniotic membrane after resecting ocular surface squamous neoplasia of the fornix

A Review of Current Uses of Amniotic Membrane Transplantation in Ophthalmic Plastic and Reconstructive Surgery

“…In 1 retrospective case series of ocular surface squamous neoplasia lesions arising from the fornix, the authors noted using AMT to reconstruct the bulbar conjunctiva and buccal mucosa grafts for the palpebral conjunctiva because they provide more lid stability than AMT alone when tarsus needs to be removed. 56 In a retrospective interventional case series using ultra-thick amniotic membrane grafts, the authors show successful re-epithelialization of the conjunctiva and adequate reconstruction of the fornix after resection of tumors and cryotherapy. 13 They suggest that ultra-thick amniotic membrane grafting may be superior to conventional thickness single and multilayer amniotic membrane transplantation for certain cases, including those with large conjunctival defects as it was easier to suture and lasted weeks compared to days.…”

“…Patient populations have included those with conjunctival melanoma with eyelid involvement, orbital sebaceous carcinoma involving the lower eyelid, squamous cell and basal cell carcinoma, and superficial lower eyelid defects after Mohs surgery. 13,[56][57][58][59][60][61][62][63][64] One case series describes the use of dehydrated amniotic membrane placed over superficial defects of the lower eyelid after Mohs surgery measuring up to 2.5 × 1.5 cm and reported successful healing in 3 patients without surgical reconstruction. 63 All three cases had a minimal extension of the Mohs defect into the orbicularis oculi.…”