Midterm Outcomes of Endovascular Therapy for TASC II D Femoropopliteal Lesions with Critical Limb Ischemia: A Retrospective Analysis

Liu, Peng; Zheng, Lihua; He, Xinqi; Yan, Yang; Zhang, Like; Zhang, Lei; Zhang, Feng

doi:10.1016/j.avsg.2022.08.004

Cited by 4 publications

(2 citation statements)

References 28 publications

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“…[1 ] Age ≥60 years [2 ] Stenosis of a major intracranial artery supplying the territory of the ischemic event ≥50% by Computed Tomography Angiography (CTA) [3 ] IS identified on MRI or TIA within the last 3 weeks [4 ] Iinformed consent from patients or their legal representatives Exclusion criteria [1 ] Contraindication or allergy to antiplatelet agents or contrast [2 ] Uncontrolled severe hypertension: systolic blood pressure ≥180 mmHg or diastolic blood pressure ≥115 mmHg [3 ] Severe vascular diseases such as intracranial aneurysm, moyamoya disease, etc. [4 ] Cardioembolic IS or TIA, and high-risk sources of cardio-embolism [5 ] History of symptomatic non-traumatic intracranial hemorrhage [6 ] Use of anticoagulants and non-steroidal anti-inflammatory drugs [7 ] Any other haemorrhagic disease [8 ] Bleeding predisposition [9 ] Blood clotting disorders artery was defined as the level of A2 (the postcommunicating segment of the anterior cerebral artery), M2 (the Sylvian segment of the middle cerebral artery) or P2 (the ambient segment of the posterior cerebral artery) (15). The primary efficacy outcome was defined as the first recurrence of TIA or IS.…”

Section: Inclusion Criteriamentioning

confidence: 99%

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Efficacy and safety of low dose aspirin plus clopidogrel in the treatment of elderly patients with symptomatic intracranial artery stenosis

Song

Zhang²,

Liu³

et al. 2023

Front. Neurol.

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BackgroundAs one of the most common causes of stroke, symptomatic intracranial artery stenosis (sICAS) is a great threat to public health, and its financial burden is substantial, with annual direct high medical costs particularly in China. Currently, the long-term use of conventional dual antiplatelet therapy (DAPT) as the primary modality of treatment for sICAS decreases the risk of stroke recurrence but increases the risk of bleeding. We aimed to evaluate the efficacy and safety of low dose aspirin plus clopidogrel for the treatment of sICAS in the elderly population.MethodsThis randomized, controlled study included 181 older patients with transient ischemic attack (TIA) or ischemic stroke (IS) attributed to sICAS, who were recruited between April 2015 and November 2020. The 90 patients assigned to the low dose therapy group included aspirin, 75 mg, plus clopidogrel, 50 mg, daily for 90 and 91 patients assigned to the conventional group included aspirin, 100 mg, plus clopidogrel, 75 mg, daily for 90 days (aspirin or clopidogrel alone daily thereafter) were included in this intention-to-treat analysis. Efficacy and safety analyses were done in this trial.ResultsOne hundred eighty-one eligible elderly patients with sICAS were enrolled in this trial. The median age was 70 years ranged 60–83 years. Seventy-five participants were with TIA and 106 with IS. The median time of follow-up was 30 months ranged 1–36 months. Ninety patients were assigned randomly to the low dose group and 91 patients to the conventional group. The rate of primary, secondary and composite efficacy were not significantly different between the low dose and conventional group (P > 0.05). The rate of composite safety outcome was 7.8% (7/90) in the low dose group, which was lower than 17.6% (16/91) in the conventional group (χ2 = 3.921, P = 0.048). At the time of last follow-up, 17 (9.4%) of 181 patients developed GI injuries, which occurred in four (4.4%) of 90 patients in the low dose group and in 13 (14.3%) of 91 patients in the conventional group (χ2 = 4.058, P = 0.044). The primary efficacy outcome occurred in six (18.2%) of 33 patients with severe sICAS and in 22 (38.6%) of 57 patients with moderate sICAS (χ2 = 4.064, P = 0.044) in the low dose group.ConclusionIn this study, the safety of low dose aspirin combined with clopidogrel proved to be equally efficient and significantly safer than those of conventional dose within 24 months in elderly patients with sICAS. However, the small size of this study limits the validity of the results. Further larger longitudinal and randomized controlled trials are necessary to evaluate the role of low dose DAPT in the patients with sICAS.

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Section: Inclusion Criteriamentioning

confidence: 99%

“…The Composite safety outcome included both primary and secondary safety outcome. Coronary artery disease was defined history of angina, myocardial infarction, or prior coronary artery revascularization (9). Any event related to the outcomes was reviewed by professionals who were masked to DAPT medications.…”

Section: Inclusion Criteriamentioning

confidence: 99%