Midregional pro-atrial natriuretic peptide as a prognostic marker in pneumonia

Prat, Cristina; Lacoma, Alícia; Domínguez, José; Papassotiriou, Jana; Morgenthaler, Nils G.; Andreo, Felipe; Tudela, Pere; Ruiz-Manzano, Juan; Ausina, V.

doi:10.1016/j.jinf.2007.07.018

Cited by 38 publications

(39 citation statements)

References 27 publications

(25 reference statements)

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“…On the contrary, in a study by Hohenthal et al, CRP correlated significantly with the PSI and was valuable for assessing disease severity [36]. Our results confirm previous findings that have shown that MR-proANP correlates with PSI, CURB-65, the later development of complications, and the length of hospitalization [16,37,38,44,45]. MR-proANP is involved in physiopathological changes that occur during infections, and this is one of the reasons why its levels are increased in patients with CAP.…”

Section: Discussionsupporting

confidence: 88%

“…MR-proANP is involved in physiopathological changes that occur during infections, and this is one of the reasons why its levels are increased in patients with CAP. The proposed cut-off for the prediction of complications and mortality is similar to those reported in previous studies [16,44].…”

Section: Discussionsupporting

confidence: 72%

“…Whether CRP can be used for the etiological diagnosis of CAP has been extensively evaluated, but the results have been discordant [11,32,[34][35][36]. In the case of MR-proANP, there is no relationship with the etiology corroborating that MR-proANP levels reflect physiopathological dysfunction rather than etiology [16,37,38]. Regarding radiographic involvement, the PCT, CRP and neopterin levels were higher in patients with multilobar pneumonia, although in our previous experience, PCT correlated significantly with lobar involvement [6].…”

Section: Discussionmentioning

confidence: 99%

“…Neopterin has been shown to improve the discrimination between the bacterial and viral etiology of LRTIs [14,15]. And, finally, mid regional pro-atrial natriuretic peptide (MR-proANP), which is the stable C-terminal fragment of the atrial natriuretic peptide precursor, has been evaluated as a marker of severity in LRTIs, especially during pneumonia and exacerbations of chronic obstructive pulmonary disease (COPD), its levels increasing with the severity of infection and the development of complications [16][17][18][19].…”

mentioning

confidence: 99%

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Usefulness of consecutive biomarkers measurement in the management of community-acquired pneumonia

Lacoma

Rodríguez

Prat

et al. 2011

Eur J Clin Microbiol Infect Dis

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The aim of this study was to investigate whether procalcitonin (PCT), neopterin, C-reactive protein (CRP), and mid regional pro-atrial natriuretic peptide (MR-proANP) levels at admission and during the clinical course can be useful for the management of patients with pneumonia. The study population consisted of 75 patients with clinical and radiological diagnosis of pneumonia. Serum samples were collected at admission and during hospitalization. Complications were defined as intensive care unit (ICU) admission or death. The levels of PCT were significantly higher in pneumonia of definite bacterial origin in comparison to probable bacterial or unknown origin. The PCT levels were higher in pneumococcal pneumonia. The PCT and MR-proANP levels increased significantly according to the Pneumonia Severity Index (PSI). All biomarkers levels are higher in patients developing complications and who were dying. The serial levels of MR-proANP remain significantly elevated in patients developing complications and in patients classified in PSI and CURB-65 risk groups. In patients not developing complications, there is a significant decrease in the PCT levels. PCT can be useful for identifying pneumonia etiology. PCT and MR-proANP levels correlate with pneumonia severity rules. PCT and MR-proANP serial measurements can be useful for predicting short-term prognosis. Systemic biomarkers can provide additional information regarding clinical evolution, because these are dynamic and can be measured daily.

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Section: Discussionsupporting

confidence: 88%

Section: Discussionsupporting

confidence: 72%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

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Usefulness of consecutive biomarkers measurement in the management of community-acquired pneumonia

Lacoma

Rodríguez

Prat

et al. 2011

Eur J Clin Microbiol Infect Dis

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“…Nevertheless, we believe that biomarkers should be tested specifically in populations whose management is the most difficult, suggesting that our population constitutes an interesting target. The interpretation of MR-proANP can also be questioned in patients with concomitant infection, because MR-proANP has a prognostic value in severe infections (32 ) and community-acquired pneumonia (33,34 ). Indeed, CHF and infection are often seen together in elderly patients (35 ).…”

Section: Discussionmentioning

confidence: 99%

Midregional Pro–Atrial Natriuretic Peptide for the Diagnosis of Cardiac-Related Dyspnea according to Renal Function in the Emergency Department: A Comparison with B-Type Natriuretic Peptide (BNP) and N-Terminal ProBNP

et al. 2010

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BACKGROUND:Although renal dysfunction influences the threshold values of B-type natriuretic peptide (BNP) and N-terminal proBNP (NT-proBNP) in diagnosis of cardiac-related dyspnea (CRD), its effects on midregional pro-atrial natriuretic peptide (MRproANP) threshold values are unknown. We evaluated the impact of renal function on MR-proANP concentrations and compared our results to those of BNP and NT-proBNP.

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Le peptide natriurétique atrial (ANP)

Claessens

Eche

2012

Les Biomarqueurs en Médecine D’urgence

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Midregional pro-atrial natriuretic peptide as a prognostic marker in pneumonia

Cited by 38 publications

References 27 publications

Usefulness of consecutive biomarkers measurement in the management of community-acquired pneumonia

Usefulness of consecutive biomarkers measurement in the management of community-acquired pneumonia

Midregional Pro–Atrial Natriuretic Peptide for the Diagnosis of Cardiac-Related Dyspnea according to Renal Function in the Emergency Department: A Comparison with B-Type Natriuretic Peptide (BNP) and N-Terminal ProBNP

Le peptide natriurétique atrial (ANP)

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