Midregional pro atrial natriuretic peptide: a novel important biomarker for noise annoyance-induced cardiovascular morbidity and mortality?

Abstract

Background Environmental noise exposure has been associated with increased cardiovascular morbidity and mortality. Recently, noise annoyance was shown to induce atrial fibrillation, which was accompanied by significantly increased levels of midregional pro atrial natriuretic peptide (MR-proANP). Therefore, the aim of the present study was to analyze the association between noise annoyance, MR-proANP, incident cardiovascular events, and all-cause mortality. Methods Levels of MR-proANP were measured in the first 5000 participants of the population-based Gutenberg Health Study. Annoyance was assessed separately for aircraft, road traffic, railway, neighborhood, and industrial/construction noise during the day and sleep. Results In cross-sectional analyses, aircraft noise annoyance during day and sleep, industrial/construction noise annoyance during day, and railway noise annoyance during sleep were independently associated with increased levels of MR-proANP after multivariable adjustment. After a 5-year follow-up period, there were 43 cases of incident atrial fibrillation and 103 of incident cardiovascular disease (comprising atrial fibrillation, coronary artery disease, myocardial infarction, heart failure, or stroke). Moreover, there were 301 deaths after a mean follow-up of 7.42 ± 1.66 years. An odds ratio (OR) of 2.82 ([95% confidence interval (CI) 1.86; 4.35], p < 0.0001) for incident atrial fibrillation and an OR of 1.49 ([95% CI 1.13; 1.96], p = 0.0046) for incident cardiovascular disease per 1-standard deviation (SD) increase in MR-proANP levels were found. A 36% (hazard ratio: 1.36 [95% CI 1.19; 1.55], p < 0.0001) higher risk of death was found per 1-SD increase in MR-proANP levels.

Cigarette Smoking Is Related to Endothelial Dysfunction of Resistance, but Not Conduit Arteries in the General Population—Results From the Gutenberg Health Study

“…We followed the methods of Hahad et al ( 16 ). In brief, the GHS is a population-based, prospective single-center cohort study from Mid-Western Germany including 15,010 subjects (aged 35–74 years) of the baseline examination performed from April 2007 to April 2012 at the University Medical Center Mainz, Germany.…”

“…Fasting blood and anthropometric data were collected and routine laboratory methods were used for measurements of blood glucose, lipids, and cardiovascular risk factors. Detailed information about clinical and laboratory examinations as well as exact definition of included variables have been reported previously ( 16 , 20 , 21 ).…”

Galectin-3 for prediction of cardiac function compared to NT-proBNP in individuals with prediabetes and type 2 diabetes mellitus

“…All individuals provided written informed consent before study enrolment and the study procedures are conducted in line with the principles outlined in the Declaration of Helsinki and the recommendations for Good Epidemiological Practice. The rationale and design of the GHS were published previously 17 , 18 . Data acquisition was performed using a highly standardized investigational protocol at the study platform.…”

Accelerated Aging and Age-Related Diseases (CVD and Neurological) Due to Air Pollution and Traffic Noise Exposure

“…There was no correlation between those who responded to be annoyed by or sensitive to noise, implying that the effects were not via an emotional pathway and that noise-induced damage would occur independent of cognition. Conversely, population-based cohort studies clearly demonstrated a dose-dependent increase of prevalent atrial fibrillation [137], accompanied by increased midregional pro-atrial natriuretic peptide levels [138], a cardiac hormone that mirrored endothelial activation and predicted future cardiovascular events, in response to annoyance due to different noise sources, including traffic noise. These effects could possibly be impactful on future cardiovascular events [16,139].…”