Midodrine As A Bridge To Enable Use of Life Enhancing Therapies In Chronic Heart Failure

Vijayaraghavan, Krishnaswami; Little, Desiree; Mercer, Teresa; Querrey, Tamera; Wilmowski, Sarah; Win, Aye Aye; Cherukuri, Gopi; Byrne, Timothy

doi:10.1016/j.cardfail.2020.09.175

Cited by 3 publications

(1 citation statement)

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“…Side effects were seen in less than 5% of patients and were limited to headache, palpitations or jitteriness. The authors concluded that midodrine appears to be feasible and safe and enables GDMT in patients with HFrEF associated with autonomic dysfunction and hypotension [11] . A more challenging situation, even in the hospital setting, arises when a patient with severe congestive heart failure and low blood pressure requires dialysis.…”

Section: Discussionmentioning

confidence: 97%

Use of Midodrine in Heart Failure: Two Case Reports and a Review of the Literature

Hajjiah¹,

Maadarani²,

Bitar³

et al. 2022

European Journal of Case Reports in Internal Medicine

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Hypotension in patients with heart failure is much more frequent in daily clinical practice than the 10–15% reported in clinical trials. In patients with heart failure with reduced ejection fraction (HFrEF), hypotension frequently limits the initiation and up-titration of guideline-directed medical therapy (GDMT). Midodrine is a peripheral alpha-1 agonist and a vasopressor anti-hypotensive agent approved for the treatment of orthostatic hypotension. We describe two cases where midodrine was prescribed in patients with HFrEF and hypotension.

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Section: Discussionmentioning

confidence: 97%

Use of Midodrine in Heart Failure: Two Case Reports and a Review of the Literature

Hajjiah¹,

Maadarani²,

Bitar³

et al. 2022

European Journal of Case Reports in Internal Medicine

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Evaluation of Midodrine Utilization in Patients with Cancer and Heart Failure

Irizarry-Caro,

Song,

Miller

et al. 2024

Cardiovasc Drugs Ther

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Use of midodrine in heart failure: a review

Gautam

Lamichhane

Sharma

et al. 2023

Annals of Medicine &Amp; Surgery

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Heart failure is a global health concern, affecting millions of individuals worldwide. Midodrine, an alpha-1 receptor agonist, might be a potential treatment option for patients with heart failure and concurrent hypotension. This review provides a comprehensive summary of the existing literature on the use of midodrine in heart failure patients, focusing on its pharmacology, epidemiology, and public health impact. Guideline-directed medical therapy (GDMT) is essential in heart failure management, but hypotension may limit its initiation or up-titration. Studies have shown that midodrine can improve blood pressure, reduce the need for vasopressor support, and enable the prescription of GDMT in patients who are intolerant to it due to hypotension. However, there are concerns over increased all-cause mortality in some studies, small sample sizes, and nonrandomized study designs in others. Further research, including large-scale randomized controlled trials and long-term follow-up studies, is needed to better understand the risks and benefits of midodrine use in heart failure patients, particularly in relation to GDMT. Clinicians should consider the potential advantages of midodrine against the limited evidence and potential risks before incorporating it into their clinical practice for heart failure treatment.

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Midodrine As A Bridge To Enable Use of Life Enhancing Therapies In Chronic Heart Failure

Cited by 3 publications

References 0 publications

Use of Midodrine in Heart Failure: Two Case Reports and a Review of the Literature

Use of Midodrine in Heart Failure: Two Case Reports and a Review of the Literature

Evaluation of Midodrine Utilization in Patients with Cancer and Heart Failure

Use of midodrine in heart failure: a review

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