Midnolin‐proteasome pathway for protein degradation

Abstract

Overexpression of immediate‐early genes (IEGs) has been linked to was associated with cancer progression and prognosis. In a recent study, Gu et al. reported the midnolin‐proteasome pathway, a novel ubiquitin‐independent proteasomal degradation. 1 The study provided the mechanism of rapid degradation for nuclear proteins with high unsteadiness. Targeting the midnolin‐proteasome pathway might be beneficial for cancer therapy.