Midlife sensory and motor functions improve prediction of blood‐based measures of neurodegeneration and Alzheimer's disease in late middle‐age
Adam J. Paulsen,
A. Alex Pinto,
Carla R. Schubert
et al.
Abstract:INTRODUCTIONWe assessed whether midlife sensory and motor functions added to prediction models using the Cardiovascular Risk Factors, Aging, and Incidence of Dementia Score (CAIDE) and Framingham Risk Score (FRS) improve risk predictions of 10‐year changes in biomarkers of neurodegeneration and Alzheimer's disease.METHODSLongitudinal data of N = 1529 (mean age 49years) Beaver Dam Offspring Study participants from baseline, 5‐year, and 10‐year follow‐up were included. We tested whether including baseline sensor… Show more
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