Midlatency evoked potentials attenuation and augmentation reflect different aspects of sensory gating

Boutros, Nashaat N.; Belger, Ayşenil

doi:10.1016/s0006-3223(98)00253-4

Cited by 186 publications

(141 citation statements)

References 17 publications

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“…Although this band-limited (12-20 Hz) oscillation clearly cannot account for the full deflection of the broadband N1 waveform (1-75 Hz), it does make a contribution to N1 amplitude (although Figure 7 demonstrates this empirically, it′s relatively trivial from a mathematical standpoint since the frequency range 12-20 Hz lies within the range 1-75 Hz). This implies that at least part of component N1′s well-documented modulation by ISI (Alcaini et al, 1994;Boutros and Belger, 1999;Davis et al, 1966;Kisley et al, 2004) results from the beta band′s sensitivity to this variable -as support for this, ISI-modulation for component N1 was significantly correlated to ISI-modulation for the beta band in the present study. Again, the notion that beta activity is distributed across multiple cortical regions (Roelfsema et al, 1997;von Stein et al, 1999) agrees well with the known multi-component nature of N1.…”

Section: Comparison With Previous Studies Of Sensory Gatingsupporting

confidence: 81%

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Gamma and beta neural activity evoked during a sensory gating paradigm: Effects of auditory, somatosensory and cross-modal stimulation

Kisley

Cornwell

2006

Clinical Neurophysiology

114

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Objective.-Stimulus-driven salience is determined involuntarily, and by the physical properties of a stimulus. It has recently been theorized that neural coding of this variable involves oscillatory activity within cortical neuron populations at beta frequencies. This was tested here through experimental manipulation of inter-stimulus interval (ISI).Methods.-Non-invasive neurophysiological measures of event-related gamma (30-50 Hz) and beta (12-20 Hz) activity were estimated from scalp-recorded evoked potentials. Stimuli were presented in a standard "paired-stimulus" sensory gating paradigm, where the S1 (conditioning) stimulus was conceptualized as long-ISI, or "high salience," and the S2 (test) stimulus as short-ISI, or "low salience." Three separate studies were conducted: auditory stimuli only (N=20 participants), somatosensory stimuli only (N=20), and a cross-modal study for which auditory and somatosensory stimuli were mixed (N=40).Results.-Early (20-150 ms) stimulus-evoked beta activity was more sensitive to ISI than temporally-overlapping gamma band activity, and this effect was seen in both auditory and somatosensory studies. In the cross-modal study, beta activity was significantly modulated by the similarity (or dissimilarity) of stimuli separated by a short ISI (0.5 s); a significant cross-modal gating effect was nevertheless detected.Conclusions.-With regard to the early sensory-evoked response recorded from the scalp, the interval between identical stimuli especially modulates beta oscillatory activity.Significance.-This is consistent with developing theories regarding the different roles of temporally-overlapping oscillatory activity within cortical neuron populations at gamma and beta frequencies, particularly the claim that the latter is related to stimulus-driven salience.

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Section: Comparison With Previous Studies Of Sensory Gatingsupporting

confidence: 81%

“…Neural processing of ISI has commonly been investigated with a "sensory gating" paradigm (Adler et al, 1998;Boutros and Belger, 1999;Braff and Geyer, 1990;Kisley et al, 2004). The paradigm involves the presentation of an unchanging sensory stimulus, but at varied intervals between presentations (e.g., 0.5 and 9 s).…”

Section: Introductionmentioning

confidence: 99%

Gamma and beta neural activity evoked during a sensory gating paradigm: Effects of auditory, somatosensory and cross-modal stimulation

Kisley

Cornwell

2006

Clinical Neurophysiology

114

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“…Second, cross-and/or multi-modal gating studies could help to separate modal from cross-and/or supra-modal gating processes outside the respective primary sensory areas, particularly in the frontal lobes. Third, EP-and MEGresponses outside the conventional P50-sensory-gating time window, namely in the range of 100 to 300 ms after stimulus onset, would have to be analyzed under the same topographical perspective to assess later components of the presumably multi-stage process of sensory gating (Boutros, 1999). Analyses of that latter sort would have to include the memory-relevant medial temporal areas, where specific late responses in a double-click experiments have already been demonstrated (Grunwald et al, 2003).…”

Section: Discussionmentioning

confidence: 99%

Towards a functional topography of sensory gating areas: Invasive P50 recording and electrical stimulation mapping in epilepsy surgery candidates

Kurthen

Trautner

Rosburg

et al. 2007

Psychiatry Research: Neuroimaging

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The filtering of sensory information, also referred to as "sensory gating", is impaired in various neuropsychiatric diseases. In the auditory domain, sensory gating is investigated mainly as a response decrease of the auditory evoked potential component P50 from one click to the second in a double click paradigm. In order to relate deficient sensory gating to anatomy, it is essential to identify the cortical structures involved in the generation of P50. However, the exact cerebral topography of P50 gating has remained largely unknown as yet. In a group of 17 patients with drug-resistant focal epilepsy, P50 was recorded invasively via subdural electrodes, and the topography of functionally indispensable ("eloquent") cortices was obtained by electrical stimulation mapping. These eloquent areas were involved in language, motor, and sensory functions. P50 could be identified in 13 patients in either temporal (n = 8) or midfrontal sites (n = 5). There were 6 occurrences (in 5 patients) of overlap of sites with maximal P50 responses and eloquent areas. Those were auditory (n = 1), supplementary sensorimotor (n = 3), primary motor (n = 1), and supplementary negative motor (n = 1). Results suggest that the early stage of sensory gating already involves a top-down modulation of sensory input by frontal areas.

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“…Many studies have used the P50 potential to study habituation, a component of the process of sensory gating, the ability to filter incoming information in order to attend to salient stimuli. Normal subjects show a markedly lower response to the second of closely spaced stimuli Buchwald 1986a, Boutros andBelger 1999); however, decreased habituation of the P50 potential has been reported in schizophrenia (Adler et al 1982), autism (Buchwald et al 1992), narcolepsy (Boop et al 1994), post traumatic stress disorder (Skinner et al 1999), Parkinson's Disease (Teo et al 1997(Teo et al , 1998), Huntington's Disease (Uc et al 2002) and depression . We observed no decrement in habituation in the ExPreterm population as a whole compared to the Ex-Term population.…”

Section: The P50 Potentialmentioning

confidence: 99%

Long-term deficits of preterm birth: Evidence for arousal and attentional disturbances

Hall

Huitt

Thapa

et al. 2008

Clinical Neurophysiology

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Objective-Quantitative measures of pre-attentional, attentional and frontal lobe processes were compared to evaluate quantitative measures of these deficits in Ex-Preterm vs. Ex-Term adolescents.Methods-We compared 43 Ex-Preterm with 26 Ex-Term adolescents using the P50 auditory potential, the Psychomotor Vigilance Task (PVT), a reaction time (RT) test, and Near Infrared Spectroscopy (NIRS).Results-The mean amplitude (±SE) of the P50 amplitude was similar in the Ex-Preterm (1.8 ±1.4µv) vs. Ex-Term adolescents (1.8±0.6µv, df=68, F=0.05, p=0.8), but the Ex-Preterm group showed a trimodal distribution in amplitude (High, 3.3±0.4 µv,df=42.25, F=19.2, p<0.01; Medium, 1.7±0.1 µv, df=39, F=0.41, p=0.53; Low, 0.7±0.1 µv, df=40, F=49.5, p<0.01) suggested by statistically significant variance between populations (Kolmogorov-Kuiper test, df=42.25, F=5.4, p<0.01). Mean RT was longer in Ex-Preterm (250±8 msec) vs. Ex-Term subjects (200±5 ms, df=68, F=18.8, p<0.001). PVT lapses were increased in Ex-Preterm subjects, and varied inversely with P50 amplitude (Overall Mean 17±5 lapses, df=67, F=5.34, p<0.05; Low P50 amplitude, 25±10, df=40, F=8.8, p<0.01; Medium, 21±11, df=38, F=5.37, p<0.05; High, 6±2, df=39, F=6.78, p<0.01) vs. ExTerm subjects (2±0.4 lapses, p<0.01). NIRS levels did not differ statistically, but tended to correlate with P50 amplitude in the Ex-Preterm group.Conclusions-These findings suggest differential pre-attentional, attentional and frontal lobe dysfunction in ex-preterm adolescents.Significance-These measures could provide a means to objectively assess differential dysregulation of arousal and attention in Ex-Preterm adolescents, allowing optimization of therapeutic designs.

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Midlatency evoked potentials attenuation and augmentation reflect different aspects of sensory gating

Cited by 186 publications

References 17 publications

Gamma and beta neural activity evoked during a sensory gating paradigm: Effects of auditory, somatosensory and cross-modal stimulation

Gamma and beta neural activity evoked during a sensory gating paradigm: Effects of auditory, somatosensory and cross-modal stimulation

Towards a functional topography of sensory gating areas: Invasive P50 recording and electrical stimulation mapping in epilepsy surgery candidates

Long-term deficits of preterm birth: Evidence for arousal and attentional disturbances

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