Middle to lower uterine segment embryo transfer improves implantation and pregnancy rates compared with fundal embryo transfer

Frankfurter, David; Trimarchi, James R.; Silva, Celso P; Keefe, David L.

doi:10.1016/j.fertnstert.2003.11.026

Cited by 69 publications

(52 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Despite this apparent correlation between air bubble position and embryo location in the uterus, few studies have addressed the effect of air bubble position on PR. The limited existing literature has yielded contradictory results (9,10).…”

mentioning

confidence: 99%

The effect of air bubble position after blastocyst transfer on pregnancy rates in IVF cycles

Friedman¹,

Lathi²,

Henne³

et al. 2011

Fertility and Sterility

View full text Add to dashboard Cite

mentioning

confidence: 99%

The effect of air bubble position after blastocyst transfer on pregnancy rates in IVF cycles

Friedman¹,

Lathi²,

Henne³

et al. 2011

Fertility and Sterility

View full text Add to dashboard Cite

“…Several studies recommend to ‘transfer the matter gently' [18,19,21,28,29]. A more concrete advise about the speed of the transferred catheter load is only made by Eytan et al [30], who concluded that the catheter should deliver the load gently over a period of ≥10 s. Also, there is still no consensus about the most optimal depth of embryo placement.…”

Section: Discussionmentioning

confidence: 99%

“…In early times, it was reported to position the embryo(s) 0.5 cm from the endometrial fundus [31,32,33]. In later years, studies conclude to position the embryo(s) 2 cm from the endometrial fundus [13,18,19]. Most recently, Cenksoy et al [17] reported that the optimal position of the air bubble seems to be a distance of <10 mm from the endometrial fundus, in accordance with Friedman et al [34].…”

Section: Discussionmentioning

confidence: 99%

“…Despite its relevance, the technique used in embryo transfer has received little attention and progress until recent years [2,3]. Several studies [13,17,18,19,20,21,22,23] have demonstrated that the depth of the embryo placement into the uterine cavity, as a result of the embryo transfer technique, should be considered an important factor concerning pregnancy rates. Our research group pointed out that despite standardization of the transfer by protocol, the final position of the transferred air bubbles including the embryo(s) was not accurately predictable because of dependency of the injection speed which depends on the force used to press the plunger, the resistance of the plunger and a possible uterine resistance during transfer [24].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Embryo Transfer with Controlled Injection Speed to Increase Pregnancy Rates: A Randomized Controlled Trial

Caanen

Houwen²,

Schats³

et al. 2016

Gynecol Obstet Invest

View full text Add to dashboard Cite

Background/Aims: Catheter injection speed affects depth and placement of the embryo into the uterine cavity and is shown to be highly variable in, and between, subjects in a manually performed embryo transfer. In an effort to standardize the injection speed during embryo transfer, we developed an automated transfer pump: the pump-regulated embryo transfer (PRET) device. In this randomized controlled trial, we aimed to investigate if standardization of the injection speed and pressure with this PRET results in a better controlled positioning of the transferred embryo(s). Methods: Five hundred ninety-nine in-vitro fertilization/intracytoplasmic sperm injection/frozen-thawed embryo transfer cycles were randomly assigned to the PRET or manual transfer. Positioning of the embryo(s) into the uterine cavity was measured with ultrasound. Results: The PRET device generates a significantly smaller variance of the positioning of the embryo(s) into the uterine cavity. This resulted in an ongoing pregnancy rate of 21% in the PRET versus 17% in the manual (p = 0.22) transfer group; frozen-thawed embryo transfers resulted in 17.5 versus 10.9% (p = 0.097), respectively. Conclusion: The PRET results in better controlled positioning of the embryo(s), and it also gives the opportunity to standardize embryo transfer. Whether the PRET may positively influence pregnancy rates, needs to be investigated in a multicenter trial.

show abstract

“…If this hypothesis is correct, the final implantation site of the embryos is highly dependent on random movement during the three days following embryo transfer. The only clearly undesirable embryo transfer location is injection of the embryos directly into the fallopian tubes, resulting in lower pregnancy success rates and higher ectopic pregnancy rates [12]. Routine U.S. guidance eliminates this complication.…”

Section: Discussionmentioning

confidence: 99%

Air bubble migration is a random event post embryo transfer

Confino

Zhang

Rísquez

2007

J Assist Reprod Genet

View full text Add to dashboard Cite

Introduction: Air bubble location following embryo transfer (ET) is the presumable placement spot of embryos. The purpose of this study was to document endometrial air bubble position and migration following embryo transfer.Design: Multicenter prospective case study. Materials and Methods: Eighty-eight embryo transfers were performed under abdominal ultrasound guidance in two countries by two authors. (EC, FR) A single or double air bubble was loaded with the embryos using a soft, coaxial, end opened catheters. The embryos were slowly injected 10-20 mm from the fundus. Air bubble position was recorded immediately, 30 minutes later and when the patient stood up.Results: Bubble marker location analysis revealed a random distribution without visible gravity effect when the patients stood up. The bubble markers demonstrated splitting, moving in all directions and dispersion.Conclusion: Air bubbles move and split frequently post ET with the patient in the horizontal position, suggestive of active uterine contractions. Bubble migration analysis supports a rather random movement of the bubbles and possibly the embryos. Standing up changed somewhat bubble configuration and distribution in the uterine cavity. Gravity related bubble motion was uncommon, suggesting that horizontal rest post ET may not be necessary. This report challenges the common belief that a very accurate ultrasound guided E. Confino ( ) ·

show abstract

Middle to lower uterine segment embryo transfer improves implantation and pregnancy rates compared with fundal embryo transfer

Cited by 69 publications

References 15 publications

The effect of air bubble position after blastocyst transfer on pregnancy rates in IVF cycles

The effect of air bubble position after blastocyst transfer on pregnancy rates in IVF cycles

Embryo Transfer with Controlled Injection Speed to Increase Pregnancy Rates: A Randomized Controlled Trial

Air bubble migration is a random event post embryo transfer

Contact Info

Product

Resources

About