Middle Lobe Syndrome

Harper, Fred R.

doi:10.1001/archsurg.1950.01250020702010

Cited by 10 publications

(2 citation statements)

References 5 publications

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“…2 Compression of the right middle lobe bronchus by adjacent lymph nodes containing caseous material may progress to frank ulceration of the bronchial wall, allowing lymph node contents to be discharged into the bronchial lumen and possibly leading to bronchial stricture or occlusion. 18 In addition, there is a paucity of collateral ventilation in the middle lobe. The degree of collateral ventilation varies with the individual differences in the degree of development of the interlobar fissures.…”

Section: Pathophysiologymentioning

confidence: 99%

“…MLS most commonly presents with chronic cough, right-sided chest pain, purulent sputum, hemoptysis, and weight loss. 3,4,9,11,12,18 Fever, dyspnea, wheezing, fatigue, exacerbation of symptoms during a superimposed upper respiratory infection, and recurrent bronchopneumonia have also been described. [2][3][4]11,12 Patients with MLS may occasionally be asymptomatic or present with massive hemorrhage.…”

Section: Clinical Presentationmentioning

confidence: 99%

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Middle Lobe Syndrome

Robinson¹,

Lee²

2007

Clinical Pulmonary Medicine

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Middle lobe syndrome (MLS) commonly presents with chronic cough, right-sided chest pain, purulent sputum, hemoptysis, weight loss, and pneumonia. The etiology of MLS was initially described as external compression of the right middle lobe bronchus. However, it is known that multiple etiologies of MLS exist, involving intrinsic and extrinsic bronchial compression. The etiologies include broncholithiasis, peribronchial lymphadenopathy, foreign body aspiration, and bronchiectasis. The presenting complaints of MLS are similar regardless of the etiology, referable to the common factor of obstruction of the right middle lobe.Lateral chest radiography in MLS characteristically demonstrates a wedge-shaped opacity in the right middle lobe. We present a case of a 38-year-old Korean female with a remote medical history significant for pulmonary tuberculosis, who presented for evaluation of an enlarging right hilar mass with associated productive cough, chills, night sweats, right-sided pleuritic chest pain, weight loss, and fever. She was diagnosed with MLS, which was successfully managed surgically with a middle lobe lobectomy with complete resolution of symptoms.

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Section: Pathophysiologymentioning

confidence: 99%