Middle East Respiratory Syndrome Coronavirus and Children

Bartenfeld, Michael; Griese, Stephanie; Uyeki, Timothy M.; Gerber, Susan I.; Peacock, Georgina

doi:10.1177/0009922816678820

Cited by 20 publications

(30 citation statements)

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“…Severe acute respiratory syndromes associated with coronaviruses seem to have a children-sparing pattern, as suggested by the available literature on SARS-CoV (2003) and MERS-CoV (2012) epidemics [11][12][13]. Stockman et al reported that children and adolescents are susceptible to SARS-associated coronavirus infection, although the clinical course and outcome are more favourable in children younger than 12 years of age compared with adolescents and adults: in fact no deaths were reported among children with SARS [11,12].…”

Section: Sars Coronaviruses and Childrenmentioning

confidence: 91%

“…Stockman et al reported that children and adolescents are susceptible to SARS-associated coronavirus infection, although the clinical course and outcome are more favourable in children younger than 12 years of age compared with adolescents and adults: in fact no deaths were reported among children with SARS [11,12]. Bartenfeld et al reported that the only two fatal paediatric MERS-CoV cases had severe comorbidities (infantile nephrotic syndrome and cystic fibrosis) [13].…”

Section: Sars Coronaviruses and Childrenmentioning

confidence: 99%

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Novel Coronavirus disease (COVID-19) in newborns and infants: what we know so far

et al. 2020

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Recently, an outbreak of viral pneumonitis in Wuhan, Hubei, China successively spread as a global pandemia, led to the identification of a novel betacoronavirus species, the 2019 novel coronavirus, successively designated 2019-nCoV then SARS-CoV-2). The SARS-CoV-2 causes a clinical syndrome designated coronavirus disease 2019 (COVID19) with a spectrum of manifestations ranging from mild upper respiratory tract infection to severe pneumonitis, acute respiratory distress syndrome (ARDS) and death. Few cases have been observed in children and adolescents who seem to have a more favorable clinical course than other age groups, and even fewer in newborn babies. This review provides an overview of the knowledge on SARS-CoV-2 epidemiology, transmission, the associated clinical presentation and outcomes in newborns and infants up to 6 months of life.

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Section: Sars Coronaviruses and Childrenmentioning

confidence: 91%

Section: Sars Coronaviruses and Childrenmentioning

confidence: 99%

Novel Coronavirus disease (COVID-19) in newborns and infants: what we know so far

et al. 2020

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“…Ähnliche Effekte im Kindesalter wurden in Bezug auf SARS und MERS gesehen – insgesamt scheint auch hier in dieser Altersgruppe der Verlauf deutlich milder als bei Erwachsenen zu sein 44 45 . Die Langzeitauswirkungen der SARS-CoV-2-Infektion auf das Neugeborene sollten Gegenstand künftiger Forschung sein.…”

Section: Haupttextunclassified

Perinatale Aspekte der SARS-CoV-2 Infektion

Longardt

Winkler

Pecks

2020

Z Geburtshilfe Neonatol

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ZusammenfassungDas neuartige Coronavirus SARS-CoV-2 hat sich zu einer Pandemie entwickelt, in der es noch viele Unbekannte gibt. Die Modalitäten der Übertragung, unterschiedlichen Symptome und Ausprägungen sowie Begleiterscheinung der Erkrankung sind unzureichend charakterisiert. Gerade Patientengruppen in besonderen Situationen wie Schwangere und Neugeborene müssen dabei separat betrachtet werden. Das bisherige Wissen zu Schwangerschaft, Geburt und den ersten Lebenstagen ist aufgrund der spärlichen Datenlage von besonderer Unsicherheit geprägt. Es bestehen aber derzeit keine Hinweise für eine signifikante Verschlechterung im maternalen und perinatalen Outcome. Viele Schwangere mit SARS-CoV-2-Infektion bleiben asymptomatisch. Die Möglichkeit einer vertikalen Transmission auf das Kind kann nicht sicher ausgeschlossen werden. Hinweise hierauf ergaben sich jedoch bislang nur aus Einzelfällen. Auch Neugeboreneninfektionen sind eher selten, unspezifisch und verlaufen meist mild, wobei respiratorische Symptome dominieren. In diesem Artikel wird die bisherige Datenlage beleuchtet, um eine bessere Aufklärung, Beratung und Behandlung der Schwangeren und Neugeborenen mit SARS-CoV-2 zu ermöglichen und um Anregungen für die zukünftige Forschung zu geben.

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“…7 In general, during the SARS and MERS outbreaks, clinical infection in children was mild. 8 However, in a retrospective comparison study of children admitted to Seattle Children's Hospital with lower respiratory tract infection (LRTI) with corona-virus between 2012 and 2016, the children who were immunocompromised (85 patients) were at greater risk for severe LRTI, (ie, requiring supplemental oxygen therapy compared with to the nonimmunocompromised children [1,152 patients]). 9 The nonimmunocompromised children with LRTI who had infection with a copathogen, most frequently with respiratory syncytial virus (RSV), were younger, had an underlying pulmonary disorder, and were also at risk for requiring supplemental oxygen therapy.…”

mentioning

confidence: 99%

“…10 In general, LRTIs with coronavirus in infants and children tend to be more mild unless the infant or child has an infection with a coviral pathogen, has an underlying pulmonary disorder like asthma or cystic fibrosis, or is immunocompromised (hematologic malignancy or solid tumor). [7][8][9][10] Current guidelines for all medical professionals regarding COVID-19 include 1 :…”

mentioning

confidence: 99%