Middle East Respiratory Syndrome Coronavirus Disease in Children

Memish, Ziad A.; Al‐Tawfiq, Jaffar A.; Assiri, Abdullah M.; Alrabiah, Fahad; Hajjar, Sami Al; Albarrak, Ali; Flemban, Hesham; Alhakeem, Rafat F.; Makhdoom, Hatem Q.; Alsubaie, Sarah; Al-Rabeeah, Abdullah A.

doi:10.1097/inf.0000000000000325

Cited by 143 publications

(141 citation statements)

References 7 publications

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“…This finding strongly suggests that human-to-human transmission occurs, a hypothesis that was further supported by the full-genome deep sequencing of 21 MERS cases (20). Most children with MERS-CoV infections have been asymptomatic secondary cases, but severe disease can occur in children with underlying conditions (21). The basic reproduction number (R 0 ) was estimated to be 0.69 (95% CI, 0.50-0.92).…”

Section: Epidemiologymentioning

confidence: 96%

Middle East Respiratory Syndrome

Alsolamy

2015

Critical Care Medicine

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Section: Epidemiologymentioning

confidence: 96%

Middle East Respiratory Syndrome

Alsolamy

2015

Critical Care Medicine

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“…We thoroughly reviewed previously published literatures and data provided by the World Health Organization and the Ministry of Health Saudi Arabia 2,4,5,8) . As of www.piv.or.kr …”

Section: Discussionmentioning

confidence: 99%

“…Infections in adults show high morbidity and mortality. However, only a few cases of MERS-CoV in children have been reported in the literature 4,5) . Herein we describe the epidemiology and clinical characteristics of cases of MERS-CoV infection among children.…”

mentioning

confidence: 99%

Middle East Respiratory Syndrome Coronavirus Infection in Children

Lee

Han

2015

Pediatr Infect Vaccine

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Since 2012, outbreaks of the Middle East respiratory coronavirus (MERS-CoV) have been reported, including the Republic of Korea. To date, most of the people infected with the virus are adults. Herein we describe the clinical characteristics of cases of MERS-CoV infection among children. As of October 29, 2015, MERS-CoV has caused 34 pediatric infections, which accounts for 2.1% of all cases. The median age was 13 years (range 9 months to 17 years) and where gender has been reported (n=33), 57.6% cases were male. About half of the patients were asymptomatic and the majority of the symptomatic patients had respiratory symptoms. In general, the clinical outcome in children was favorable. Among the four patients who died of progressive pneumonia, three had documented comorbidities. MERS-CoV infection in children has a lower incidence and mortality compared to adults.

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“…The clinical course is more severe in immunocompromised patients (6), (although recent case reports indicate that some recover) (45,46), and in pregnant women, where infection has been shown to result in stillbirths. The clinical course is more likely to be mild in individuals without underlying medical conditions (7,(47)(48)(49).…”

Section: Clinical Characteristicsmentioning

confidence: 99%

Middle East respiratory syndrome coronavirus: current knowledge and future considerations

Malik¹,

Elkholy²,

Khan³

et al. 2016

East Mediterr Health J

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A literature review of publically available information was undertaken to summarize current understanding and gaps in knowledge about Middle East respiratory syndrome coronavirus (MERS-CoV), including its origin, transmission, effective control measures and management. Major databases were searched and relevant published papers and reports during 2012-2015 were reviewed. Of the 2520 publications initially retrieved, 164 were deemed relevant. The collected results suggest that much remains to be discovered about MERS-CoV. Improved surveillance, epidemiological research and development of new therapies and vaccines are important, and the momentum of recent gains in terms of better understanding of disease patterns should be maintained to enable the global community to answer the remaining questions about this disease.

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Middle East Respiratory Syndrome Coronavirus Disease in Children

Abstract: MERS-CoV disease is not limited to adults. Most cases of childhood MERS-CoV infection were asymptomatic and tested positive during contact investigation of older patients. Severe disease can occur in children with underlying conditions.

Cited by 143 publications

References 7 publications

Middle East Respiratory Syndrome

Middle East Respiratory Syndrome

Middle East Respiratory Syndrome Coronavirus Infection in Children

Middle East respiratory syndrome coronavirus: current knowledge and future considerations

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