Middle cingulate cortex function contributes to response to non-steroidal anti-inflammatory drug in cervical spondylosis patients: a preliminary resting-state fMRI study

Bai, Liang; Zhang, Lei; Chen, Yong; Yang, Li; Dongya, Ma; Li, Wei; Ye, Meng; Yaowei, Zhao; Yemi, Wang; Zeng, Qingliang; Zhuang, Quankui

doi:10.1007/s00234-022-02964-3

Cited by 7 publications

(5 citation statements)

References 52 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…According to the comprehensive analysis above, we herein aimed to fulfill the following three tasks: (1) Identifying the resilience level and its potential predictive factors, including above-mentioned psychological factors (i.e., hope, optimism, perceived social support, and perceived stress) among CS patients; (2) Considering that anxiety is a most common negative psychological state in CS patients (46), we also evaluated the dyadic and comprehensive relation between anxiety and other psychological variables; (3) Testing whether resilience played a mediating role in the association between other psychological variables and anxiety. We hope that our results can help improve mental health interventions in patients with CS via identifying the correlates of anxiety, especially resilience and its related factors.…”

Section: Introductionmentioning

confidence: 99%

Resilience mediates the influence of hope, optimism, social support, and stress on anxiety severity among Chinese patients with cervical spondylosis

et al. 2022

View full text Add to dashboard Cite

ObjectiveCervical spondylosis (CS) is a potential stressor threatening mental health among affected individuals. This study was to analyze resilience level and associated factors among cervical spondylosis (CS) patients, and to explore the underlying mechanism of anxiety based on resilience-focused psychological variables.MethodsResilience Scale-14 (RS-14), Zung Self-Rating Anxiety Scale (SAS), Herth Hope Index (HHI), Revised Life Orientation Test (LOT-R), Multidimensional Scale of Perceived Social Support (MSPSS), Perceived Stress Scale-10 (PSS-10) were used in this cross-sectional investigation among 250 CS patients.ResultsThe score of resilience was 65.58 ± 16.14. Hierarchical linear regression analysis revealed that hope, optimism, perceived social support, perceived stress, and whether having comorbid chronic diseases were the independent associates of resilience among CS patients, which explained 63.9% of the total variance. The structural equation model showed that hope, optimism, perceived social support and perceived stress affected anxiety via resilience, and hope and optimism also had direct effects on anxiety.ConclusionChinese patients with CS had moderate level of mental resilience, which was independently related to hope, optimism, perceived social support, perceived stress, and whether having comorbid chronic diseases. Resilience played a mediating role between various psychological variables and anxiety. Improving the level of resilience, hope, optimism and perceived social support and reducing the level of perceived stress are important strategies to reduce anxiety level. Relevant healthcare professionals should put more focus on the mental problems of Chinese CS patients and help maintain good psychological status by improving their resilience and associated psychological variables thereof.

show abstract

Section: Introductionmentioning

confidence: 99%

Resilience mediates the influence of hope, optimism, social support, and stress on anxiety severity among Chinese patients with cervical spondylosis

et al. 2022

View full text Add to dashboard Cite

show abstract

“…The middle cingulate cortex participates in reward functions and aversive responses to noxious stimulation, facilitating the prediction of pain and selection of appropriate responses to avoid noxious injury. 40,41 The inferior parietal lobule mediates attention reorientation and integration of body and sensory FIGURE 6: Shared reduction in structural and functional connectivity in small-fiber neuropathy (SFN). The brain map visualizes the connections with shared structural and functional reductions in the pain-related network of the SFN patients.…”

Section: Discussionmentioning

confidence: 99%

“…There was a shared reduction in the structural and functional connectivity among the limbic, striatal, and cognition‐integration systems: (1) between the middle cingulate cortex and inferior parietal lobule and (2) between the thalamus and putamen. The middle cingulate cortex participates in reward functions and aversive responses to noxious stimulation, facilitating the prediction of pain and selection of appropriate responses to avoid noxious injury 40,41 . The inferior parietal lobule mediates attention reorientation and integration of body and sensory information, 42 and activates during both innocuous and noxious thermal stimulation 43,44 .…”

Section: Discussionmentioning

confidence: 99%

Limbic Connectivity Underlies Pain Treatment Response in Small‐Fiber Neuropathy

Chao

Hsieh

Lin

et al. 2022

Annals of Neurology

View full text Add to dashboard Cite

Objective Small‐fiber neuropathy (SFN) is characterized by neuropathic pain due to degeneration of small‐diameter nerves in the skin. Given that brain reorganization occurs following chronic neuropathic pain, this study investigated the structural and functional basis of pain‐related brain changes after skin nerve degeneration. Methods Diffusion‐weighted and resting‐state functional MRI data were acquired from 53 pathologically confirmed SFN patients, and the structural and functional connectivity of the pain‐related network was assessed using network‐based statistic (NBS) analysis. Results Compared with age‐ and sex‐matched controls, the SFN patients exhibited a robust and global reduction of functional connectivity, mainly across the limbic and somatosensory systems. Furthermore, lower functional connectivity was associated with skin nerve degeneration measured by reduced intraepidermal nerve fiber density and better therapeutic response to anti‐neuralgia medications, particularly for the connectivity between the insula and the limbic areas including the anterior and middle cingulate cortices. Similar to the patterns of functional connectivity changes, the structural connectivity was robustly reduced among the limbic and somatosensory areas, and the cognition‐integration areas including the inferior parietal lobule. There was shared reduction of structural and functional connectivity among the limbic, somatosensory, striatal, and cognition‐integration systems: (1) between the middle cingulate cortex and inferior parietal lobule and (2) between the thalamus and putamen. These observations indicate the structural basis underlying altered functional connectivity in SFN. Interpretation Our findings provide imaging evidence linking structural and functional brain dysconnectivity to sensory deafferentation caused by peripheral nerve degeneration and therapeutic responses for neuropathic pain in SFN. ANN NEUROL 2023;93:655–667

show abstract

“…Increasing evidence has uncovered structural and functional brain changes in regions associated with pain modulation, and such changes have been associated with pain intensity, disability, and pain sensitivity in patients with chronic pain [13][14][15][16]. In these studies, Amplitude of Low Frequency Fluctuation (ALFF), which is a widely used rs-fMRI metric, has gained much attention for its simplicity, interpretability and replicability among commonly used rs-fMRI metrics [17][18][19]. Moreover, recent studies have shown that ALFF was tightly associated with cerebral blood flow [20,21] and task-evoked activation [22,23] and could serve as a biomarker for predicting the analgesic-response in cervical spondylosis patients with chronic neck pain [17].…”

Section: Introductionmentioning

confidence: 99%

“…In these studies, Amplitude of Low Frequency Fluctuation (ALFF), which is a widely used rs-fMRI metric, has gained much attention for its simplicity, interpretability and replicability among commonly used rs-fMRI metrics [17][18][19]. Moreover, recent studies have shown that ALFF was tightly associated with cerebral blood flow [20,21] and task-evoked activation [22,23] and could serve as a biomarker for predicting the analgesic-response in cervical spondylosis patients with chronic neck pain [17]. Therefore, ALFF is ideally suited for investigating PAP in DCM patients, considering the current lack of the knowledge for the underlying brain mechanism.…”

Section: Introductionmentioning

confidence: 99%

Preoperative pain hypersensitivity is associated with axial pain after posterior cervical spinal surgeries in degenerative cervical myelopathy patients: a preliminary resting-state fMRI study

Chu

et al. 2023

Insights Imaging

View full text Add to dashboard Cite

Objective To test whether preoperative pain sensitivity is associated with the postoperative axial pain (PAP) in degenerative cervical myelopathy (DCM) and to explore its underlying brain mechanism. Methods Clinical data and resting-state fMRI data of 62 DCM patients along with 60 age/gender matched healthy participants were collected and analysed. Voxel-wise amplitude of low frequency fluctuation (ALFF) was computed and compared between DCM patients and healthy controls. Correlation analyses were performed to reveal the association between the clinical metrics and brain alterations. Clinical data and ALFF were also compared between DCM patients with PAP and without PAP. Results (1) Relative to healthy participants, DCM patients exhibited significantly lower preoperative pain threshold which is associated with the PAP intensity; (2) Relative to patients without PAP, PAP patients exhibited increased ALFF in mid-cingulate cortex (MCC) and lower preoperative pain threshold; (3) Further, multivariate pattern analysis revealed that MCC ALFF provide additional value for PAP vs. non-PAP classification. Conclusion In conclusion, our findings suggest that preoperative pain hypersensitivity may be associated with postoperative axial pain in degenerative cervical myelopathy patients. This finding may inspire new therapeutic ideas for patients with preoperative axial pain.

show abstract

Middle cingulate cortex function contributes to response to non-steroidal anti-inflammatory drug in cervical spondylosis patients: a preliminary resting-state fMRI study

Cited by 7 publications

References 52 publications

Resilience mediates the influence of hope, optimism, social support, and stress on anxiety severity among Chinese patients with cervical spondylosis

Resilience mediates the influence of hope, optimism, social support, and stress on anxiety severity among Chinese patients with cervical spondylosis

Limbic Connectivity Underlies Pain Treatment Response in Small‐Fiber Neuropathy

Preoperative pain hypersensitivity is associated with axial pain after posterior cervical spinal surgeries in degenerative cervical myelopathy patients: a preliminary resting-state fMRI study

Contact Info

Product

Resources

About