Middle cerebral artery velocity is associated with the severity of MRI brain injury in neonates received therapeutic hypothermia

Ho, Sheng-Yuan; Chiang, Ming-Chou; Lin, Jainn-Jim; Chou, I-Jun; Lee, Cheng-Chung; Mok, Tze Yee Diane; Lai, Ming-Wei; Wu, I-Hsyuan; Wong, Alex Mun-Ching; Wang, Huei-Shyong; Lin, Kuang-Lin; Wang, Yishan; Chou, Cheng-Che; Sing, Kong Shu; Su, I-Chen; Lien, Reyin

doi:10.1016/j.bj.2020.08.002

Cited by 4 publications

(6 citation statements)

References 23 publications

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“…Hence, future studies should include Doppler assessment of thalamic vessels in addition to the anterior cerebral artery and middle cerebral arteries. Studies from the therapeutic hypothermia era have reported that abnormal resistive index or CBFV correlate well with MRI findings 76–78 . In a recent study, abnormal resistive index (≤0.55 or ≥0.90) values were reported in 61% of neonates with mild, 76% with moderate, and 100% with severe HIE.…”

Section: Discussionmentioning

confidence: 93%

“…Studies from the therapeutic hypothermia era have reported that abnormal resistive index or CBFV correlate well with MRI findings. [76][77][78] In a recent study, abnormal resistive index (≤0.55 or ≥0.90) values were reported in 61% of neonates with mild, 76% with moderate, and 100% with severe HIE. Additionally, among infants with mild HIE who had abnormal resistive index, 45% had abnormal MRI and seizure on aEEG.…”

Section: Discussionmentioning

confidence: 97%

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Does abnormal Doppler on cranial ultrasound predict disability in infants with hypoxic‐ischaemic encephalopathy? A systematic review

Rath

Rao

Suryawanshi

et al. 2022

Develop Med Child Neuro

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Aim: To evaluate whether abnormal resistive index or cerebral blood flow velocity (CBFV) on cranial ultrasound predicts disability (≥1 year) in infants with hypoxicischaemic encephalopathy (HIE). Method:This was a systematic review and meta-analysis of studies comparing developmental outcomes of infants with HIE with normal versus abnormal resistive index or CBFV.Results: Twenty-six studies were included (pre-therapeutic hypothermia era, 20; therapeutic hypothermia era, six). Data from 15 studies (pre-therapeutic hypothermia, 10; therapeutic hypothermia, five) were available for meta-analysis. Pooled sensitivity and specificity, summary area under the receiver operating characteristic curve, and diagnostic odds ratio of resistive index or CBFV for predicting 'death or severe disability' were as follows. Pre-therapeutic hypothermia era: 0.83 (95% confidence interval [CI] 0.45-0.97) and 0.92 (95% CI 0.74-0.98), 0.94 (95% CI 0.92-0.96), 54 (95% CI 7-391). Therapeutic hypothermia era (measurements before therapeutic hypothermia): 0.62 (95% CI 0.41-0.80) and 0.96 (95% CI 0.88-0.99), 0.93 (95% CI 0.89-0.94), 23 (95% CI 6-91). Therapeutic hypothermia era (measurements during/ after therapeutic hypothermia): 0.51 (95% CI 0.24-0.78) and 0.83 (95% CI 0.73-0.90), 0.81 (95% CI 0.78-0.85), 5 (95% CI 2-13). Overall Grading of Recommendations Assessment, Development and Evaluation (GRADE) rating of evidence was 'low' or 'very low'.Interpretation: Low-level evidence suggests that abnormal resistive index or CBFV can predict death or disability with high sensitivity and specificity in infants with HIE who are not cooled. The specificity of these tests was high when performed before starting cooling in infants who received therapeutic hypothermia.

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Section: Discussionmentioning

confidence: 93%

Section: Discussionmentioning

confidence: 97%

Does abnormal Doppler on cranial ultrasound predict disability in infants with hypoxic‐ischaemic encephalopathy? A systematic review

Rath

Rao

Suryawanshi

et al. 2022

Develop Med Child Neuro

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“…In addition to local cryotherapy, existing treatments, such as hypothermia ( Ho et al, 2021 ) or vital organ protection, such as aortic arch replacement surgery ( Salem et al, 2020 ) in which the patient’s body temperature is lowered to a minimum of around 17°C ( Pastukhov et al, 2016 ), rarely reduces the patient’s body temperature below 17°C; additionally, considering that excessive temperatures may lead to the occurrence of blood cell rupture and hemolysis. Therefore, in this study, the dielectric properties of blood samples were measured and analyzed at six temperatures:17, 22, 27, 32, 37, and 39°C.…”

Section: Discussionmentioning

confidence: 99%

Temperature dependence of dielectric properties of blood at 10 Hz–100 MHz

Wang

Dong²,

Liu³

et al. 2022

Front. Physiol.

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The temperature dependence of the dielectric properties of blood is important for studying the biological effects of electromagnetic fields, electromagnetic protection, disease diagnosis, and treatment. However, owing to the limitations of measurement methods, there are still some uncertainties regarding the temperature characteristics of the dielectric properties of blood at low and medium frequencies. In this study, we designed a composite impedance measurement box with high heat transfer efficiency that allowed for a four/two-electrode measurement method. Four-electrode measurements were carried out at 10 Hz-1 MHz to overcome the influence of electrode polarization, and two-electrode measurements were carried out at 100 Hz-100 MHz to avoid the influence of distribution parameters, and the data was integrated to achieve dielectric measurements at 10 Hz-100 MHz. At the same time, the temperature of fresh blood from rabbits was controlled at 17–39°C in combination with a temperature-controlled water sink. The results showed that the temperature coefficient for the real part of the resistivity of blood remained constant from 10 Hz to 100 kHz (−2.42%/°C) and then gradually decreased to −0.26%/°C. The temperature coefficient of the imaginary part was positive and bimodal from 6.31 kHz to 100 MHz, with peaks of 5.22%/°C and 4.14%/°C at 126 kHz and 39.8 MHz, respectively. Finally, a third-order function model was developed to describe the dielectric spectra at these temperatures, in which the resistivity parameter in each dispersion zone decreased linearly with temperature and each characteristic frequency increased linearly with temperature. The model could estimate the dielectric properties at any frequency and temperature in this range, and the maximum error was less than 1.39%, thus laying the foundation for subsequent studies.

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“…Ho et al. conducted a retrospective cohort study in the neonatal ICU, assessing the correlation between middle cerebral artery (MCA) flow velocity and the severity of hypoxic ischemic encephalopathy (HIE) in neonates who received therapeutic hypothermia (TH) [ 43 ]. TH has been introduced in 2010 in Taiwan as a treatment for HIE newborn patients and consensus recommendations were determined in 2015 [ 44 ].…”

Section: Also In This Issuementioning

confidence: 99%

“…concluded that mean flow velocity in MCA is correlated to the severity of MRI brain injury. The team suggests the use of transcranial Doppler sonography as a potential predictive tool for neurodevelopmental outcomes during the first days in asphyxiated neonates [ 43 ].…”

Section: Also In This Issuementioning

confidence: 99%

One day at a time

Kattner¹

2021

Biomedical Journal

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In this issue of Biomedical Journal we get to know measures to prevent a nosocomial COVID-19 outbreak, a compound that is able to stall SARS-CoV-2 replication, and the connection between air pollution and COVID-19 cases. Another article allows an insight into the potential of treating HIV combining a conventional drug and low level laser therapy. Furthermore, the advantages of awake craniotomy are presented, the efficacy of IRES is examined, and plant extracts are on the one hand explored as a nociceptive agent and on the other hand as therapeutic approach against breast cancer. We learn about drug resistance in liver cancer, a mutation involved in a rare inflammatory disorder, and lung surgery related unilateral vocal fold paralysis. Finally, the success of emergency endotracheal intubations across different hospital units is compared, the importance of monitoring cerebral blood flow in asphyxiated neonates is elucidated, and resistance variants in hepatitis C virus are examined. A study about the necessity to perform quantitative cardiac MRI in Asian population is presented, and an approach is shown on how to augment the effect of platelet-rich plasma injections in chronic knee osteoarthritis.

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Middle cerebral artery velocity is associated with the severity of MRI brain injury in neonates received therapeutic hypothermia

Cited by 4 publications

References 23 publications

Does abnormal Doppler on cranial ultrasound predict disability in infants with hypoxic‐ischaemic encephalopathy? A systematic review

Does abnormal Doppler on cranial ultrasound predict disability in infants with hypoxic‐ischaemic encephalopathy? A systematic review

Temperature dependence of dielectric properties of blood at 10 Hz–100 MHz

One day at a time

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