Midbrain Dopaminergic Neuron Development is Regulated by Two Molecularly Distinct Subtypes of Radial Glia Cells
Emilía Sif Ásgrímsdóttir,
Luca Fusar Bassini,
Pia Rivetti di Val Cervo
et al.
Abstract:Understanding midbrain dopaminergic (mDA) neuron development is key to advancing cell replacement therapies for Parkinson's disease (PD). Recent single-cell RNA-sequencing (scRNA-seq) studies have identified different subtypes of transient radial glia (Rgl) cell types in the developing mouse and human ventral midbrain. However, their individual functions and their impact on mDA neuron development are unclear. Here we analyze the transcriptome of endogenous mouse and human ventral midbrain Rgl and assess the fu… Show more
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