Midazolam in dentistry

McGimpsey, J G; Kawar, P.; Gamble, J. A. S.; Browne, Emer; Dundee, John W.

doi:10.1038/sj.bdj.4805120

Cited by 32 publications

(6 citation statements)

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“…After its launch, early clinical work on midazolam was carried out assuming its potency to be twice that of diazepam (13)(14)(15)(16). Even in these studies there is some hint that this may not be a true reflection of potency, as the studies all mention greater amnesia and one [13] demonstrated greater respiratory side effects when diazepam and midazolam were given in a 2:1 ratio.…”

Section: Discussionmentioning

confidence: 99%

Small bolus injections of intravenous midazolam for upper gastrointestinal endoscopy: a study of 788 consecutive cases

Smith

Bell

Quine

et al. 1993

Brit J Clinical Pharma

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Section: Discussionmentioning

confidence: 99%

Small bolus injections of intravenous midazolam for upper gastrointestinal endoscopy: a study of 788 consecutive cases

Smith

Bell

Quine

et al. 1993

Brit J Clinical Pharma

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“…Several large-scale studies that screened for sexual hallucinations in the context of sedative use failed to identify any cases. [67][68][69] However, in a study of 1500 women who had undergone endoscopy or dental treatment, Dundee 70 identified four who had complained of sexual assault during the procedure. All four had been sedated with midazolam in dosages of ≥0.1 mg/kg body weight, whereas none in the group with lower dosages had reported sexually laden incidents.…”

Section: Sedativesmentioning

confidence: 99%

The Diagnostic Spectrum of Sexual Hallucinations

Blom,

van Veen,

van Rooijen

et al. 2024

Harv Rev Psychiatry

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Sexual hallucinations are little known, yet often extremely burdening, phenomena. In this systematic review, we summarize what is known about their phenomenology, prevalence, etiopathology, ensuing distress, and treatment options. Sexual hallucinations can be experienced as genital or orgasmic sensations, although other sensory modalities can also be involved. With the notable exception of orgasmic auras in the context of epilepsy, sexual hallucinations tend to be distressing and embarrassing in nature. Our analysis of 79 studies (together describing 390 patients) indicates that sexual hallucinations are more frequent in women than in men, with a sex ratio of 1.4:1, and that they are most prevalent in schizophrenia spectrum disorders, with rates ranging from 1.4% in recently admitted patients to 44% in chronically hospitalized patients. Other underlying conditions include epilepsy, the incubus phenomenon (possibly the most prevalent cause in the general population, associated with sleep paralysis), narcolepsy, and sedative use. As regards the sedative context, we found more medicolegal than purely medical cases, which sadly underlines that not all sexually explicit sensations experienced in anesthesia practice are indeed hallucinations. In the absence of evidence-based treatment protocols for sexual hallucinations, practice-based guidelines tend to focus on the underlying condition. Further research is needed, especially in the fields of substance abuse, posttraumatic stress disorder, and borderline personality disorder, where only anecdotal information on sexual hallucinations is available. Moreover, awareness of sexual hallucinations among health professionals needs to be improved in order to facilitate counseling, diagnosis, and treatment.

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“…Dans les autres études en chirurgie orale, les constantes étaient suivies de façon secondaire. Si une baisse de la pression artérielle était observée [38,39], elle était non significative, transitoire et sans conséquences cliniques.…”

Section: Effets Sur Les Fonctions Autonomesunclassified

Le midazolam. 1^repartie : pharmacologie

Descroix

André²,

Pong

2012

Med Buccale Chir Buccale

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Résumé -Les benzodiazépines constituent une classe de médicaments qui regroupent un nombre important de molécules ayant des propriétés pharmacologiques communes (anxiolytiques, sédatives, hypnotiques, amnésiques, myorelaxantes et anticonvulsivantes). Il s'agit pour la plupart de molécules hautement lipophiles dont les indications thérapeutiques sont larges, allant de l'anxiolyse à l'anesthésiologie. Le midazolam, de part ses propriétés physicochimiques singulières, se démarque des autres benzodiazépines et représente à ce titre la molécule la plus étudiée et la plus utilisée en anesthésiologie, notamment pour la sédation quelle qu'en soit la profondeur. Avant d'envisager ses indications et son utilisation pour la sédation consciente en chirurgie orale, il convient de préciser ses différentes caractéristiques pharmacologiques. Abstract -Midazolam. Part I: Pharmacology.Benzodiazepines are a class of drugs that include a large number of molecules with common pharmacological properties (anxiolytic, sedative, hypnotic, amnesic, anticonvulsant and muscle-relaxing). They are mostly highly lipophilic molecules which therapeutic indications are broad, ranging from anxiolysis to anesthesia. Midazolam, because of its unique physicochemical properties, is different from other benzodiazepines and thus represents the molecule most studied and most widely used in anaesthesia, including sedation regardless of depth. Before considering its indications and its use for conscious sedation in oral surgery, it should clarify its different pharmacological characteristics.

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Midazolam in dentistry

Cited by 32 publications

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Small bolus injections of intravenous midazolam for upper gastrointestinal endoscopy: a study of 788 consecutive cases

Small bolus injections of intravenous midazolam for upper gastrointestinal endoscopy: a study of 788 consecutive cases

The Diagnostic Spectrum of Sexual Hallucinations

Le midazolam. 1^repartie : pharmacologie

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Midazolam in dentistry

Cited by 32 publications

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Small bolus injections of intravenous midazolam for upper gastrointestinal endoscopy: a study of 788 consecutive cases

Small bolus injections of intravenous midazolam for upper gastrointestinal endoscopy: a study of 788 consecutive cases

The Diagnostic Spectrum of Sexual Hallucinations

Le midazolam. 1repartie : pharmacologie

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Le midazolam. 1^repartie : pharmacologie