Midazolam co-induction and laryngeal mask insertion

Midazolam reduces the dose of propofol required for induction of anaesthesia and laryngeal mask airway insertion

“…The effect of midazolam on reducing propofol requirements for laryngeal mask insertion is similar to two studies by Driver and his colleagues that studied propofol and alfentanil with midazolam [5,6]. In these studies propofol was injected on a strict dose per kilogram basis, using three different dose regimens, whereas we infused propofol very slowly until the patient did not respond to verbal command.…”

“…Recently, several studies have examined co-induction techniques on the conditions for laryngeal mask insertion using combinations of rapid acting opioids or midazolam combined with thiopental or propofol [5±9]. Co-induction with propofol, midazolam and alfentanil has been shown to reduce propofol requirements and provides better conditions for laryngeal mask insertion compared with induction with propofol and alfentanil alone [6]. Midazolam reduces propofol requirements for the insertion of a laryngeal mask when used without opioids in both adults and [8] and children [9].…”

A comparison between midazolam co‐induction and propofol predosing for the induction of anaesthesia in the elderly

“…Other beneficial effects attributed to co‐induction are that it facilitates placement of a laryngeal mask airway (LMA™) [14], and smoothes induction, without prolonging time to discharge [15]. We were unable to demonstrate any difference in adverse events such as coughing, laryngospasm or involuntary movements between groups.…”

Sedation with propofol plus midazolam versus propofol alone for interventional endoscopic procedures: a prospective, randomized study

“…However, in the aforementioned studies both drugs were used alone or in combination for induction of anaesthesia or for laryngeal mask insertion. 21±23, 25 Reimann et al showed that sedation with propofol and midazolam is associated with a higher degree of patient comfort and a more rapid recovery when compared with a standard sedation regime of midazolam plus nalbuphine for colonoscopies. 32 To the best of our knowledge, the present study for the ®rst time compared sedation with propofol alone with the combination of propofol and midazolam for gastrointestinal endoscopic procedures.…”