MiD51 and Mff Co-assemble in Cardiolipin-Enriched Membrane Microdomains to Cooperatively Regulate Drp1-Mediated Mitochondrial Fission

Abstract

undergo large shape changes, they exhibit non-trivial surface flows, they undergo phase transitions, and they interact with surrounding objects. Modeling those requires solving coupled partial differential equations on evolving surfaces. This work presents a new, three-dimensional modeling framework to describe and simulate the mechanical behavior of cellular membranes. It is based on advanced, recently developed modeling techniques in mathematics, physics and computational analysis. Its mathematical description is entirely formulated in the general theory of differential geometry, since it is capable of describing arbitrary surface flows and shape changes. Its physical description is based on a rigorous thermodynamical treatment, since it provides coupling relations for the various physical fields. Its computational description is based on socalled isogeometric surface finite elements, since they are capable of representing surface flow, shape and constitution to high accuracy. The capabilities of the new framework are illustrated by several challenging numerical examples. Those include endocytosis, adhesive contact and deformation-induced surface flows.

Oestrogenic Regulation of Mitochondrial Dynamics

“…The tethering of OMM and IMM is achieved by the function of Opa1 [108]. Once bound to the surface of OMM, Drp1 also interacts with Mff to form a higher-order oligomeric complex [115]. The pool of cardiolipin at the OMM then allows the fully assembled Drp1 to instigate OMM fission [116].…”