Mid-trimester amniotic fluid angiogenin, lactate dehydrogenase and fibronectin in the prediction of preterm delivery

Madazli, Rıza; Atis, Alev; Uzun, Hafize; Aksu, Feridun

doi:10.1016/s0301-2115(02)00264-6

Cited by 17 publications

(13 citation statements)

References 11 publications

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“…31 Madazli et al reported that although amniotic fluid LDH levels are high in preterm delivery patients, LDH was not effective in predicting preterm delivery. 41 We did not find any statistical significance in maternal and amniotic fluid LDH levels of patients with preterm delivery and IUGR. Measurement of different isotypes of LDH in most studies and unknown variation of LDH during normal pregnancy may explain the different results in the published work.…”

Section: Discussioncontrasting

confidence: 61%

Mid‐trimester maternal serum and amniotic fluid biomarkers for the prediction of preterm delivery and intrauterine growth retardation

Özgü-Erdinç

Cavkaytar

Aktulay

et al. 2014

J of Obstet and Gynaecol

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Section: Discussioncontrasting

confidence: 61%

Mid‐trimester maternal serum and amniotic fluid biomarkers for the prediction of preterm delivery and intrauterine growth retardation

Özgü-Erdinç

Cavkaytar

Aktulay

et al. 2014

J of Obstet and Gynaecol

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“…66,85 The number of case participants enrolled in case-control studies ranged from 5 to 882, 55,91 and the corresponding number of controls ranged from 5 to 1372. 55,91 Thirty-nine studies (n = 18 368 women) reported on 18 inflammation-related biomarkers, 21-59 28 (n = 71 609 women) reported on eight placental proteins/ hormone-related biomarkers, three (n = 359 women) reported on two angiogenesis-related biomarkers, [88][89][90] two (n = 971 women) reported on one coagulation-related biomarker, 58,91 and one (n = 10 women) reported on proteomics-related biomarkers. 92 Eleven studies evaluated more than one test.…”

Section: Resultsmentioning

confidence: 99%

“…Two studies reported data on angiogenin, 88,89 two studies reported data on the thrombin-antithrombin III complex, 58,91 and one study reported data on soluble endoglin. 90 The predictive accuracy of these biomarkers for preterm birth before 34 and 37 weeks of gestation was minimal to moderate (positive and negative LRs between 1.1 and 6.7, and between 0.4 and 1.0, respectively).…”

Section: Angiogenesis-and Coagulation-related Biomarkersmentioning

confidence: 99%

Novel biomarkers for the prediction of the spontaneous preterm birth phenotype: a systematic review and meta-analysis

Conde-Agudelo

Papageorghiou

Kennedy

et al. 2011

BJOG: An International Journal of Obstetrics &Amp; Gynaecology

145

114

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Background Being able to predict preterm birth is important, as it may allow a high-risk population to be selected for future interventional studies and help in understanding the pathways that lead to preterm birth.Objective To investigate the accuracy of novel biomarkers to predict spontaneous preterm birth in women with singleton pregnancies and no symptoms of preterm labour.Search strategy Electronic searches in PubMed, Embase, Cinahl, Lilacs, and Medion, references of retrieved articles, and conference proceedings. No language restrictions were applied.Selection criteria Observational studies that evaluated the accuracy of biomarkers proposed in the last decade to predict spontaneous preterm birth in asymptomatic women. We excluded studies in which biomarkers were evaluated in women with preterm labour.Data collection and analysis Two reviewers independently extracted data on study characteristics, quality, and accuracy. Data were arranged in 2 · 2 contingency tables and synthesised separately for spontaneous preterm birth before 32, 34, and 37 weeks of gestation. We used bivariate meta-analysis to estimate pooled sensitivities and specificities, and calculated likelihood ratios (LRs).Main results A total of 72 studies, including 89 786 women and evaluating 30 novel biomarkers, met the inclusion criteria. Only three biomarkers (proteome profile and prolactin in cervicovaginal fluid, and matrix metalloproteinase-8 in amniotic fluid) had positive LRs > 10. However, each of these biomarkers was evaluated in only one small study. Four biomarkers had a moderate predictive accuracy (interleukin-6 and angiogenin, in amniotic fluid; human chorionic gonadotrophin and phosphorylated insulin-like growth factor binding protein-1, in cervicovaginal fluid). The remaining biomarkers had low predictive accuracies.Conclusions None of the biomarkers evaluated in this review meet the criteria to be considered a clinically useful test to predict spontaneous preterm birth. Further large, prospective cohort studies are needed to evaluate promising biomarkers such as a proteome profile in cervicovaginal fluid.

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“…That is, apoptosis induction is closely associated with the LDH leakage from the virus-infected chorion cells. LDH level in amniotic fluid is known to be one of markers for predicting fetal membrane damage [19,20] . Consequently, the present study provides a possible diagnostic application of LDH level using clinical samples, such as amniotic fluid and vaginal swab washings, to predict the extent of tissue damage of fetal membranes via apoptosis induced by influenza virus infection.…”

Section: Discussionmentioning

confidence: 99%

“…It has been demonstrated that higher levels of LDH activity in amniotic fluids are associated with chorioamnionitis [19] or preterm deliveries [20] , suggesting that the LDH levels in amniotic fluids are a useful marker for predicting the extent of fetal membrane damage. Therefore, LDH levels in amniotic fluid may be used to predict the extent of fetal membrane damage during influenza virus infection.…”

Section: Introductionmentioning

confidence: 99%

Lactate Dehydrogenase Leakage as a Marker for Apoptotic Cell Degradation Induced by Influenza Virus Infection in Human Fetal Membrane Cells

et al. 2009

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Objective: In order to elucidate the implication of apoptosis in lactate dehydrogenase (LDH) leakage from influenza virus-infected cells, the effects of a general caspase inhibitor, N-t-Boc-Asp(OMe)-fluoromethylketone (Boc-D-fmk), on LDH leakage, apoptosis induction and virus proliferation were examined. Methods: Cultured human fetal membrane chorion and amnion cells were incubated with or without Boc-D-fmk after influenza virus infection. LDH leakage was estimated by measuring LDH activities in the culture supernatants and cell lysates. The extent of apoptosis was determined by caspase-3 protein cleavage and DNA fragmentation. Virus proliferation was determined by a plaque-forming assay. Results: While virus proliferation was observed in both chorion and amnion cells, the virus infection resulted in LDH leakage, caspase-3 protein cleavage, and oligonucleosomal DNA fragmentation, all of which were observed only in the chorion cells and inhibited by the presence of Boc-D-fmk except for the virus proliferation. Conclusion: LDH level in amniotic fluid is known to be one of markers for predicting fetal membrane damage. Therefore, this study provides a possible diagnostic application of LDH level to predict the extent of tissue damage of fetal membranes via apoptosis induced by influenza virus infection.

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Mid-trimester amniotic fluid angiogenin, lactate dehydrogenase and fibronectin in the prediction of preterm delivery

Cited by 17 publications

References 11 publications

Mid‐trimester maternal serum and amniotic fluid biomarkers for the prediction of preterm delivery and intrauterine growth retardation

Mid‐trimester maternal serum and amniotic fluid biomarkers for the prediction of preterm delivery and intrauterine growth retardation

Novel biomarkers for the prediction of the spontaneous preterm birth phenotype: a systematic review and meta-analysis

Lactate Dehydrogenase Leakage as a Marker for Apoptotic Cell Degradation Induced by Influenza Virus Infection in Human Fetal Membrane Cells

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