Mid-term pulmonary sequelae after hospitalisation for COVID-19: The French SISCOVID cohort

Calcaianu, George; Degoul, Samuel; Michau, Bénédicte; Payen, Thibault; Gschwend, Anthony; Fore, Mathieu; Iamandi, Carmen; Morel, Hugues; Oster, Jean-Philippe; Bizieux, A.; Nocent-Ejnaini, C.; Carvallo, Cécile; Romanet, S; Goupil, F.; Leurs, Amélie; Legrand, Marie-Germaine; Portel, L.; Claustre, Johanna; Calcaianu, Mihaela; Bresson, Didier; Debieuvre, D.

doi:10.1016/j.resmer.2022.100933

Cited by 5 publications

(5 citation statements)

References 23 publications

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“…fibrotic changes) motivating their use as salvage therapy, when it was not yet considered the standard of care. Such an effect was not found in previous studies assessing it [ 17 , 18 , 28 , 29 , 35 ], except one showing corticosteroids were associated with severe impairment in D LCO (<60% predicted) at 6 months [ 36 ], nor in our multivariate analysis focusing on critical WHO 7–9 patients.…”

Section: Discussioncontrasting

confidence: 82%

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Respiratory recovery trajectories after severe-to-critical COVID-19: a 1-year prospective multicentre study

et al. 2023

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BackgroundSurvivors of severe-to-critical COVID-19 may have functional impairment, radiological sequelae and persistent symptoms requiring prolonged follow-up. This pragmatic study aimed to describe their clinical follow-up and determine their respiratory recovery trajectories, and factors that could influence them and their health-related quality of life.MethodsAdults hospitalised for severe-to-critical COVID-19 were evaluated at 3 months and up to 12 months post-hospital discharge in this prospective, multicentre, cohort study.ResultsAmong 485 enrolled participants, 293 (60%) were reassessed at 6 months and 163 (35%) at 12 months; 89 (51%) and 47 (27%) of the 173 ones initially managed with standard oxygen were reassessed at 6 and 12 months, respectively. At 3 months, 34%, 70% and 56% of the participants had a restrictive lung defect, impaired DLCOand significant radiological sequelae, respectively. During extended follow-up, DLCOand FVC (% of predicted value) increased by means of +4 points at 6 months, and +6 points at 12 months. Sex, body mass index, chronic respiratory disease, immunosuppression, pneumonia extent or corticosteroid use during acute COVID-19 and prolonged invasive mechanical ventilation (IMV) were associated with DLCOat month 3, but not its trajectory thereafter. Among 475 (98%) patients with at least one chest computed-tomography scan during follow-up, 196 (41%) had significant sequelae on their last images.ConclusionAlthough pulmonary function and radiological abnormalities improved up to 1 year post-acute-COVID-19, high percentages of severe-to-critical disease survivors, including a notable proportion of those managed with standard oxygen, had significant lung sequelae and residual symptoms justifying prolonged follow-up.

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Section: Discussioncontrasting

confidence: 82%

“…Such effect was not found in previous studies assessing it [17,18,28,29,35], except one showing corticosteroids were associated with severe impairment in DL CO (<60% pred.) at 6 months [36], nor in our multivariate analysis focusing on critical WHO 7-9 patients.…”

Section: Discussionmentioning

confidence: 80%

Respiratory recovery trajectories after severe-to-critical COVID-19: a 1-year prospective multicentre study

et al. 2023

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“…In such initially severe patients, thoracic high-resolution computed tomography at reassessment showed persistent interstitial opacities in 44% of them, and pulmonary function tests (PFTs) showed gas exchange impairment in 39% (as defined by a diffusing capacity of the lung for carbon monoxide (DLCO) < 70% of theoretical value and/or a drop in oxygen saturation ≥ 4% during the 6-minute walk test). These data are in line with a recently published, larger French multicentric cohort [2] .…”

supporting

confidence: 92%

Reply to Noel-Savina and collaborators: DM and VC impairment after COVID-19

Gille

Sesé

Planès

2023

Respiratory Medicine and Research

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“…This precluded observation of their specific association with NETs and cirDNA markers, as well as with aCL. In addition, the PAP patients studied may have had symptoms of different origins: (i), being secondary to COVID‐19–induced damage to the lung, heart, skeletal muscle, kidneys, or brain; (ii) persistent debilitating symptoms (post‐COVID syndrome or “long COVID‐19” illness) in patients with no apparent organ damage; or (iii), symptoms originating in both co‐occurring clinical conditions 12,30 . Nonetheless, in light of the statistical difference found between NS, S, and PAP patients versus HI, we postulate that uncontrolled NETosis activation resulting from SARS‐CoV2 infection may be sustained by a feedback loop resulting from systemic NETs by‐products release as we previously speculated 3 .…”

Section: Discussionmentioning

confidence: 94%

Persistence of neutrophil extracellular traps and anticardiolipin auto‐antibodies in post‐acute phase COVID‐19 patients

Pisareva

Badiou

Mihalovičová

et al. 2022

Journal of Medical Virology

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HAL is a multi-disciplinary open access archive for the deposit and dissemination of scientific research documents, whether they are published or not. The documents may come from teaching and research institutions in France or abroad, or from public or private research centers. L'archive ouverte pluridisciplinaire HAL, est destinée au dépôt et à la diffusion de documents scientifiques de niveau recherche, publiés ou non, émanant des établissements d'enseignement et de recherche français ou étrangers, des laboratoires publics ou privés.

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Mid-term pulmonary sequelae after hospitalisation for COVID-19: The French SISCOVID cohort

Cited by 5 publications

References 23 publications

Respiratory recovery trajectories after severe-to-critical COVID-19: a 1-year prospective multicentre study

Respiratory recovery trajectories after severe-to-critical COVID-19: a 1-year prospective multicentre study

Reply to Noel-Savina and collaborators: DM and VC impairment after COVID-19

Persistence of neutrophil extracellular traps and anticardiolipin auto‐antibodies in post‐acute phase COVID‐19 patients

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