Although their parent stars no longer exist, the isotopic and chemical compositions and microstructure of individual stardust grains identified in meteorites provide unique constraints on dust formation and thermodynamical conditions in stellar outflows 1-4. Novae are stellar explosions that take place in the hydrogen-rich envelope accreted onto the surface of a white dwarf in a close binary system 5. The energy released by a suite of nuclear processes operating in the envelope 2 powers a thermonuclear runaway, resulting in the ejection of processed material into the interstellar medium. Spectral fitting of features observed in the infrared spectra of dust-forming novae provided the first evidence of the co-condensation of both carbonaceous and silicate dust in stellar outflows within the 50 to 100 days after explosion 6-11. Here we report the identification of an O-rich inclusion, composed of both silicate and oxide nanoparticles, inside a graphite spherule that originated in the ejecta of a low-mass CO nova 12. This observation provides laboratory evidence of the co-condensation of O-and C-rich dust in nova outbursts, and is consistent with the transport and mixing of materials between chemically distinct clumps within the nova ejecta. Dust in stellar and interstellar environments is traditionally studied using space or ground-based telescopes but the laboratory study of circumstellar (presolar) grains identified in extraterrestrial materials (e.g., meteorites) has opened up a new field in astronomy and astrophysics, providing direct ground-truth information on individual stars. Such presolar grains are nanometer-to micrometer-sized minerals, amorphous grains, or aggregates of them, and can include materials such as nanodiamond, SiC, graphites, oxides, and silicates 1,2. Over the last two decades, about 2000 presolar graphite spherules have been identified and studied exclusively from the acid-resistant residues of the three carbonaceous chondrites: Murchison (CM2), Orgueil (CI1), and Qingzhen (EH3) 13-15. While most presolar graphite spherules originated from lowmetallicity asymptotic-giant-branch stars (∼50%) and core-collapse supernovae (∼25%), the remaining grains are hypothesized to have also originated from other types of stars, e.g., born-again AGB and Jtype stars 14,15. A few presolar graphite grains also have isotopic compositions suggesting possible origins in the ejecta of novae 16. Novae are traditionally classified as neon and non-neon, which reflects the composition of the white dwarf that hosts the explosion, i.e., ONe (O-and Ne-rich) and CO (C-and O-rich), respectively 5. Similarly to other SiC, silicates, and oxides with putative nova origins, these