Mid dermal elastolysis

Maghraoui, S; Grossin, M; Crickx, B; Blanchet, Philippe; Belaïch, S

doi:10.1016/s0190-9622(08)80581-6

Cited by 28 publications

(13 citation statements)

References 10 publications

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“…The morphological and clinical differential diagnosis criteria of MDE, mainly versus some elastolytic disorders such as anetoderma, post-inflammatory elastolysis, cutis laxa, granulomatous slack skin and perifollicular elastolysis, have long been the subject of debate [6,12,13,16,19,23,27]. At the present time, MDE can be distinguished from other skin disorders of the elastic tissue by morphological and clinical critiera.…”

Section: Discussionmentioning

confidence: 99%

“…In the case reported here the clinical and histological features were diagnostic of MDE. MDE usually affects patients without any history of inflammatory skin diseases [2,8,16,19,20]. In some cases, however, onset is preceded, even by many months, by episodes of urticaria or reactions to drugs [7,9,12,13,23].…”

Section: Discussionmentioning

confidence: 99%

“…Mid-dermal elastolysis (MDE) is regarded as a distinct new form of elastic tissue disorder [6,8,13,16,19,23,26]. The main clinical aspect of this disease is the appearance on the trunk, abdomen and arms of symmetrically distributed aflegmasic patches of fine wrinkles which give the skin an aged appearance.…”

Section: Introductionmentioning

confidence: 99%

“…The main clinical aspect of this disease is the appearance on the trunk, abdomen and arms of symmetrically distributed aflegmasic patches of fine wrinkles which give the skin an aged appearance. These are sometimes associated with small perifollicular protrusions, more common on the trunk, telangiectases and erythematous patches [6,13,16,20]. Histopathological examination shows a typical focal loss of elastic tissue in the upper mid-dermis [23] whereas the elastic fibres in the papillary and reticular dermis are normal.…”

Section: Introductionmentioning

confidence: 99%

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Mid-dermal elastolysis: an ultrastructural and biochemical study

et al. 1995

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Mid-dermal elastolysis (MDE) is a particular elastic tissue disorder in which selective loss of elastic fibres occurs in the mid-dermis. It is clinically characterized by the appearance of fine wrinkling of the epidermis and perifollicular protrusion which gives the skin an aged appearance. It is sometimes associated with an inflammatory event such as urticaria while other cases are regarded as idiopathic. The pathogenesis of MDE is still obscure. Some authors have underlined the role of macrophage activation and others have imputed UV radiation. We report here a typical case of MDE arising after several attacks of solar urticaria. Electron microscopic and biochemical studies were carried out. Ultrastructural examination showed active elastophagocytosis by macrophages and mast cells, often degranulated, near phagocytosing cells. Biochemical studies demonstrated that fibroblasts derived from lesional skin of the MDE patient produced high levels of elastase and cathepsin G compared with fibroblasts from a healthy sex- and age-matched control. Phagocytosis of morphologically normal elastic tissue is a noticeable characteristic feature of MDE. In our case mast-cell activation and the abnormal synthesis and/or release of fibroblast elastolytic enzymes seemed to play a role in the pathogenesis of the MDE.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Mid-dermal elastolysis: an ultrastructural and biochemical study

et al. 1995

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“…Wir möchten somit die kürzlich von Maghraoui [21] aufgestellte Hypo-these eines klinischen Kontinuums zwischen akuter inflammatorischer Phase bis hin zu einem nicht entzündlichen Endstadium der MDE unterstützen, in dem die häufiger beobachtete Kombination der morphologischen Typen I und II eine Intermediärphase zwischen entzündlichen Typ II und nicht inflammtorischem Typ I im Sinne eines "burned out" [5] darstellen könnte. In dieses Kontinuum zwischen inflammatorischer und nicht inflammtorischer Elastolyse der mittleren Dermis wäre dann auch das AERZG einzureihen (Abb.…”

Section: Besprechungunclassified

Elastolyse der mittleren Dermis und anuläres elastolytisches Riesenzellgranulom: Unterschiedliche Stadien im klinischen Spektrum der dermalen Elastolyse?

et al. 1997

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In recent years there has been increased interest in diseases showing degeneration of dermal elastic tissue. Mid dermal elastolysis is a rare dermatosis, which is histopathologically characterized by mid dermal loss of elastic tissue. Both papular and patchy forms, as well as inflammatory and non-inflammatory variants, have been described. A 70-year-old woman had annular patches. In their center the clinical and histopathological findings suggested non-inflammatory mid dermal elastolysis whereas the red and slightly elevated margins showed clinical and histopathological features of annular elastolytic giant cell granuloma. Based on our case and a review of the literature, we discuss the differential diagnosis of dermal elastolysis and hypothesize that a number of lesions histologically showing mid dermal elastolysis may represent different inflammatory or non-inflammatory stages of one disease which may overlap or change from one form into another.

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