Mid‐childhood lung function in a cohort of children with “new bronchopulmonary dysplasia”

Fortuna, Manuela; Carraro, Silvia; Temporin, Eva; Berardi, Mariangela; Zanconato, Stefania; Salvadori, Severo; Lago, Paola; Frigo, Anna Chiara; Filippone, Marco; Baraldi, Eugenio

doi:10.1002/ppul.23422

Cited by 48 publications

(36 citation statements)

References 30 publications

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“…Decreasing FEV 1 /FVC from 8 to 18 years of age in children born preterm with BPD was shown by Fortuna et al [36] and Doyle et al [10], and between school age and adolescence in children born moderate to late preterm (at 32–36 GA) by Thunqvist et al [17]. Nevertheless, the clinical relevance of this observation remains to be evaluated.…”

Section: Discussionmentioning

confidence: 94%

Lung function development after preterm birth in relation to severity of Bronchopulmonary dysplasia

et al. 2017

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BackgroundBronchopulmonary dysplasia (BPD) is a strong risk factor for respiratory morbidity in children born preterm. Our aims were to evaluate lung function in adolescents born preterm with and without a history of BPD, and to assess lung function change over time from school age.MethodsFifty-one individuals born in Stockholm, Sweden between gestational ages 24 to 31 weeks (23 neonatally diagnosed with respiratory distress syndrome (RDS) but not BPD, and 28 graded as mild (n = 17), moderate (n = 7) or severe (n = 4) BPD) were examined in adolescence (13–17 years of age) using spirometry, impulse oscillometry (IOS), plethysmography, and ergospirometry. Comparison with lung function data from school age (6–8 years of age) was also performed.ResultsAdolescents with a history of BPD had lower forced expiratory volume in 1 s (FEV1) compared to those without BPD (−0.61 vs.-0.02 z-scores, P < 0.05), with lower FEV1 values significantly associated with BPD severity (P for trend 0.002). Subjects with severe BPD had higher frequency dependence of resistance, R5–20, (P < 0.001 vs. non-BPD subjects) which is an IOS indicator of peripheral airway involvement. Between school age and adolescence, FEV1/FVC z-scores decreased in all groups and particularly in the severe BPD group (from −1.68 z-scores at 6–8 years to −2.74 z-scores at 13–17 years, p < 0.05 compared to the non-BPD group).ConclusionsOur results of spirometry and IOS measures in the BPD groups compared to the non-BPD group suggest airway obstruction including involvement of peripheral airways. The longitudinal result of a decrease in FEV1/FVC in the group with severe BPD might implicate a route towards chronic airway obstruction in adulthood.

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Section: Discussionmentioning

confidence: 94%

Lung function development after preterm birth in relation to severity of Bronchopulmonary dysplasia

et al. 2017

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“…BPD infants also had significantly lower weight and length z‐scores compared to non‐BPD infants, and a higher length growth velocity between the two tests was associated with better improvements in forced expiratory flows. Fortuna et al obtained longitudinal lung function data at 8 and 12 years in 48 children born at <29 weeks GA; 28 of these children had BPD. Similar to the findings in infants, FVC was not significantly different between the BPD and non‐BPD children, but all preterm children had lower forced expiratory flows compared to health controls, with the BPD children having even lower flows compared to non‐BPD children.…”

Section: Physiology and Lung Function Testingmentioning

confidence: 99%

Pediatric pulmonology year in review 2016: Part 2

et al. 2017

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Our journal covers a broad range of research and scholarly topics related to children's respiratory disorders. For updated perspectives on the rapidly expanding knowledge in our field, we will summarize the past year's publications in our major topic areas, as well as selected publications in these areas from the core clinical journal literature outside our own pages. The current review covers articles on neonatal lung disease, pulmonary physiology, and respiratory infection.Word count: 71 3

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“…Esta doença é, em potencial, uma desordem do desenvolvimento do sistema respiratório do recém-nascido pré-termo, na qual, o pulmão ainda imaturo, não atinge toda sua estrutura morfológica e funcional, que resulta na formação de grandes alvéolos[2] com superfície reduzida de trocas gasosas[3] e por consequência gera uma obstrução do fluxo aéreo pulmonar e uma sobrecarga dos músculos principais da respiração na tentativa de vencer a resistência das vias aéreas e adequar a ventilação pulmonar [4,5].…”

Section: Introductionunclassified

Impacto Da Displasia Broncopulmonar Na Musculatura Respiratória Acessória De Lactentes.

DArcadia¹,

Oliveira²,

Pereira³

et al. 2018

Anais Do v Congresso Brasileiro De Eletromiografia E Cinesiologia E X Simpósio De Engenharia Biomédica

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Resumo:Introdução: A displasia broncopulmonar (DBP) é uma doença pulmonar crônica que acomete geralmente prematuros que necessitaram de oxigênio por mais de 28 dias de vida. Existe na literatura pouca informação sobre a forma como a DBP pode afetar os músculos respiratórios, bem como a possível indução de fadiga sobre esses músculos. Diante desse contexto, nossa hipótese nesta pesquisa foi avaliar a possibilidade de fadiga na musculatura respiratória acessória ( IntroduçãoA Displasia broncopulmonar (DBP) é considerada uma doença pulmonar crônica que acomete neonatos que permanecem com dependência de oxigênio, em concentrações acima de 21%, por um período igual ou superior a 28 dias de vida [1]. Esta doença é, em potencial, uma desordem do desenvolvimento do sistema respiratório do recém-nascido pré-termo, na qual, o pulmão ainda imaturo, não atinge toda sua estrutura morfológica e funcional, que resulta na formação de grandes alvéolos[2] com superfície reduzida de trocas gasosas[3] e por consequência gera uma obstrução do fluxo aéreo pulmonar e uma sobrecarga dos músculos principais da respiração na tentativa de vencer a resistência das vias aéreas e adequar a ventilação pulmonar [4,5].Assim, os músculos acessórios da respiração são acionados, permitindo elevação da caixa torácica na inspiração [6][7][8], repouso dos músculos diafragma e intercostal interno, contração muscular abdominal e expiração forçada, além da mobilização de secreções e prevenção de atelectasias [7,8]. Esta situação deve ser considerada, pois afeta justamente a função do diafragma e da MRA [7], podendo interferir diretamente na postura corporal, gerando restrições na mobilidade

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Mid‐childhood lung function in a cohort of children with “new bronchopulmonary dysplasia”

Cited by 48 publications

References 30 publications

Lung function development after preterm birth in relation to severity of Bronchopulmonary dysplasia

Lung function development after preterm birth in relation to severity of Bronchopulmonary dysplasia

Pediatric pulmonology year in review 2016: Part 2

Impacto Da Displasia Broncopulmonar Na Musculatura Respiratória Acessória De Lactentes.

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