Micturitional disturbance in progressive supranuclear palsy

Neuronal loss in Onuf's nucleus in three patients with progressive supranuclear palsy

“…As for the Onuf 's nucleus, its role in sphincter control and its failure in MSA have been emphasized by previous investigators. 8,30,31 Our study has shown that the mean absolute neuronal cell number is reduced to less than 50% of normal and that there is also a trend for cell diameters to be smaller than normal in PSP cases with clinical evidence of bladder dysfunction. With regard to the correlation between the changes in Onuf 's nucleus and those seen by ourselves and others in the whole spinal cord, our results are at variance with those by Kikuchi and colleagues, 35 who observed a craniocaudal gradient in their cases, the least severe changes being observed at the lower levels.…”

Neurological diseases that cause detrusor hyperactivity with impaired contractile function

“…This widespread pathology could explain the presence of DHIC in both PD and MSA. In addition, progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD) are also known to show both detrusor hyperactivity and detrusor hypocontractility [Sakakibara et al, 1993[Sakakibara et al, , 2004. DHIC in PSP and CBD could also be explained by their widespread pathology.…”

Progressive supranuclear palsy presenting with urinary retention and sleep apnea

“…The diagnosis of PSP in this case was based on (1) clinical features of slowly progressive ophthalmoplegia for vertical gaze, axial rigidity and bradykinesia, cerebellar ataxia, pseudobulbar palsy, cognitive decline, and bladder dysfunction [2,5], and (2) MRI features of a typical midbrain atrophy that appeared as a hummingbird sign [6] or penguin sign [7]. The most common bladder dysfunction in PSP is urinary urgency/frequency and urinary incontinence [5].…”

“…The clinical pictures are characterized by ophthalmoplegia for vertical gaze, axial dystonia and rigidity, cerebellar ataxia, pseudobulbar palsy, and cognitive decline [2]. Bladder dysfunction in PSP is reported in 89% of patients [5], and urinary urgency/frequency is the most common [5]. Neither urinary retention nor sleep apnea has been reported as a feature in PSP.…”