259. Enuresis and spontaneous cure rate: study of 1129 enuretics. A long-term follow-up of 1129 children with noctumal enuresis, not treated by the electric alarm, has shown that the annual spontaneous cure rate between 5 and 9 years of age was 14%, between 10 and 14 years 16%, and between 15 and 19 years 16%. 33 patients (3%) were still wetting after 20 years.Organic cause for enuresis and the ineffectiveness of drug therapy are discussed.In spite of numerous reports on the treatment of enuresis, it is surprising that there is little or no information regarding spontaneous cure rates at each year of age. In order to obtain this information we have followed up all those children who attended the Enuretic Clinic from 1952 to 1959 and who had not been treated by the electric alarm. Questionnaires were sent to 1483 parents and 1157 replies were received.We define enuresis as an involuntary discharge of urine by a child of 5 years or more. It may be nocturnal, nocturnal and diurnal, or diurnal alone. Primary nocturnal enuresis refers to the child who has never been dry at night, and secondary or acquired nocturnal enuresis refers to the child who has been dry for at least a year before the onset of enuresis. 55 A detailed history was obtained from the mother in 97% of cases and from the father or relatives in the remainder. The first 800 patients were subjected to a detailed neurological examination in