Abstract:Comparative study of various activating factors for obtaining derivatives of pyrazole and isoxazole systems were described, including microwave, ultrasonic action and SMUI methods. Reactions using the appropriate β-dicarbonyl compounds with hydrazine or hydroxylamine reached completion in 5-10 minutes. The next β-dicarbonyl structure modified under SMUI conditions was curcumin, natural compound that is a candidate for therapeutic use. The pyrazole and isoxazole heterocyclic derivatives of curcumin were obtained in a short time 10-20 minutes. Both microwave and ultrasonic factors promoted heterocyclization, but the use of SMUI proved to be fundamental for reducing the reaction time.