Microwave Thermotherapy for Benign Prostatic Hyperplasia with the Dornier Urowave: Results of a Randomized, Double-blind, Multicenter, Sham-controlled Trial

Roehrborn, Claus G.; Preminger, Glenn M.; Newhall, Phil; Denstedt, John D.; Razvi, Hassan; Chin, Ling; Perlmutter, Aaron P.; Barzell, Winston; Whitmore, Willet F.; Fritzsch, Ralph J.; Sanders, J.; Sech, Scott M.; Womack, Sean

doi:10.1016/s0090-4295(97)00571-2

Cited by 52 publications

(26 citation statements)

References 11 publications

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“…Versus sham treatment: Several small to medium sized RCTs compared TUMT against sham treatment. In the largest trial (220 men), TUMT improved the international prostate symptom score significantly more than sham treatment (5.0 points lower, P<0.05) 49 . Versus TURP: Two small trials with follow up to 2.5 years found no difference in symptom relief between TUMT and TURP.…”

Section: Methodsmentioning

confidence: 85%

Extracts from "Clinical Evidence": Benign prostatic hyperplasia

Barry

Roehrborn

2001

BMJ

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Section: Methodsmentioning

confidence: 85%

Extracts from "Clinical Evidence": Benign prostatic hyperplasia

Barry

Roehrborn

2001

BMJ

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“…The largest difference in mean symptom score (−7.7) seen was in the 3-month data from a randomized TUMT study in 1998 [50] with the group actually undergoing treatment reporting a difference of 11.9 in AUASS. Even the most minimal decrease seen in 3-month data from TUMT studies (−5.7) [51] is larger than the ability of patient's to perceive a change in voiding as outlined by Barry et al [6].…”

Section: Surgical Treatmentsmentioning

confidence: 95%

Placebo Medication and Sham Surgery Responses in Benign Prostatic Hyperplasia Treatments: Implications for Clinical Trials

2015

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Placebo medications and sham surgeries have long been thought to be inert treatments. These groups served as a threshold to which an active treatment should be compared in a randomized trial to determine the true efficacy of the active treatment. However, surprising changes in subjective symptom scores and objective measures of voiding have been demonstrated in numerous placebo medication or sham surgery arms of trials. The exact mechanisms by which these inactive treatments augment patient outcomes are not clearly defined and multiple theories have been proposed to explain the often pronounced response. It appears that urologic outcomes are particularly prone to these effects and the astute physician should keep these responses in mind when interpreting any trial on a new therapy.

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“…Long-term studies show the maximum effects and subjective improvements occur 3 to 6 months after treatment [30,31,34], with a slight but insignificant further improvement at the 12-month follow-up visit. Recent evidence indicates that earlier improvements in symptoms and voiding function can be achieved by inserting a temporary endoprosthetic device, e.g.…”

Section: The Concept Of Tumtmentioning

confidence: 97%

“…imum urinary flow rate (Q max ) and statistically significantly QoL scores in patients with BPH [26][27][28][29][30][31]. In a recent study of 70 patients who underwent targeted TUMT, improvements of more than 50% in the IPSS, Q max and QoL scores were achieved in 74, 71 and 79% of patients, respectively [32].…”

Section: The Concept Of Tumtmentioning

confidence: 99%

Transurethral microwave thermotherapy for treatment of benign prostatic hyperplasia

Waldert¹,

Djavan²

2004

The Journal of Men's Health & Gender

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Many urologists have a high regard for the usefulness of transurethral microwave therapy (TUMT) in treating patients with lower urinary tract symptoms caused by benign prostatic hyperplasia. This therapy has been examined clinically in many centers throughout the world. The rationale for its effect on symptoms is unlike many of the other so-called minimally invasive treatment modalities. The improvement in symptoms and voiding function is greater with transurethral microwave thermotherapy than with drug therapy, and the associated morbidity is low. It also offers greater versatility than drug therapy, allowing patients with severe baseline symptoms and small prostates to be treated successfully. In addition, there has been an evolution in the technology of TUMT from low-energy to high-energy application indicating that this technique has a future in the treatment of lower urinary tract symptoms.

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Microwave Thermotherapy for Benign Prostatic Hyperplasia with the Dornier Urowave: Results of a Randomized, Double-blind, Multicenter, Sham-controlled Trial

Cited by 52 publications

References 11 publications

Extracts from "Clinical Evidence": Benign prostatic hyperplasia

Extracts from "Clinical Evidence": Benign prostatic hyperplasia

Placebo Medication and Sham Surgery Responses in Benign Prostatic Hyperplasia Treatments: Implications for Clinical Trials

Transurethral microwave thermotherapy for treatment of benign prostatic hyperplasia

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